What is the most effective antiplatelet for stroke?

Comparison with other studies. To our knowledge, the first NMA on antiplatelet drugs used after TIA or stroke was published in 2008 and included 24 studies, involving more than 42,000 participants [39]. The combination of aspirin and dipyridamole emerged as the most effective regimen in preventing vascular events.

Which anticoagulant is best for stroke?

Many experts recommend anticoagulation with IV heparin in the acute phase and subsequent oral anticoagulation for 3-24 months (target INR 2.5, range 2-3) followed by antiplatelet agents for at least 2 years.

What antiplatelet agent is most widely used for secondary prevention of stroke?

Aspirin (Acetylsalicylic acid, ASA) has a long history in the area of secondary stroke prevention. It is the main comparator agent in many recurrent stroke prevention trials, and the subject of many metareviews or systematic analyses.

What is the best antiplatelet medication?

Clopidogrel (75 mg daily) is the preferred antiplatelet.

What is the safest antiplatelet?

Clopidogrel monotherapy showed the most favourable benefit-harm profile (79% cumulative rank probability best and 77% cumulative rank probability safest). In conclusion, Clopidogrel should be the indicated antiplatelet agent in PAD patients.

Antiplatelet Agents for Secondary Stroke Prevention - Can We Be More Precise?

Which is safer aspirin or clopidogrel?

Aspirin combined with the antiplatelet drug clopidogrel is no better than aspirin alone for stroke prevention in people with a history of lacunar strokes, and the combination carries a greater risk of gastrointestinal bleeding, according to results of a trial funded by the National Institutes of Health.

Why is clopidogrel preferred to aspirin?

Several clinical trials reported that clopidogrel was superior to aspirin in secondary stroke prevention by reducing the risk of major adverse cardiovascular events (MACE).

What is better Plavix or Brilinta?

The findings come from a sub-study of the PLATO trial, which showed that Brilinta works better than Plavix at preventing heart attacks, strokes, and deaths from heart disease in people with acute coronary syndrome (ACS).

What is the alternative to clopidogrel?

Besides oral anticoagulants, such as warfarin and the more recent dabigatran[9], and niche agents, such as cilostazol and ticlopidine[10,11], the most promising alternatives to clopidogrel in those with background aspirin therapy are prasugrel and ticagrelor.

Why is ticagrelor more potent than clopidogrel?

Ticagrelor is a direct-acting oral antagonist of P2Y12-adenosine diphosphate (ADP) receptor blocker with reversibility and without catabolite activation, which can have a substantial impact on faster and greater platelet inhibition than clopidogrel [10, 11].

Which antiplatelet drug's is are first line choice when patients present with acute ischemic stroke?

Antiplatelet Therapy

Aspirin continues to be the drug of choice for the antiplatelet treatment of AIS, with administration required within 24 to 48 hours after onset of stroke symptoms. However, the guidelines emphasize that aspirin alone is not a substitute for mechanical thrombectomy or IV alteplase if indicated.

What is antiplatelet therapy for stroke?

Antiplatelet therapy is used for both the management of acute ischemic stroke and for the prevention of stroke. Antiplatelet therapy reduces the incidence of stroke in patients at high risk for atherosclerosis and in those with known symptomatic cerebrovascular disease.

Does Plavix help prevent stroke?

THURSDAY, Feb. 7, 2019 (HealthDay News) -- Taking the blood thinner Pletal (cilostazol) with either aspirin or clopidogrel (best known as Plavix) lowers stroke patients' risk of a subsequent stroke better than taking aspirin or clopidogrel alone, a new study finds.

When do you start clopidogrel after a stroke?

Recent minor non-cardioembolic ischemic stroke or high-risk TIA, DAPT with aspirin plus clopidogrel should be initiated early (ideally within 12–24 hours of symptom onset and at least within 7 days of onset) and continued for 21–90 days.

How long should you stay on Plavix after a TIA?

Based on the results of the CHANCE trial, the American Heart Association/American Stroke Association recommends clopidogrel and aspirin for 21 days starting in the first 24 hours after a minor stroke or TIA.

Do stroke patients need anticoagulation?

Anticoagulants often are prescribed to patients with recent stroke in an effort to prevent early recurrent stroke and to improve neurological outcomes. The Cerebral Embolism Study Group estimated that the risk of early recurrent embolism was 12% among untreated patients with embolic stroke.

What medication is better than Plavix?

Brilinta has been marketed and studied as a more effective drug than Plavix. It has been shown to be a better drug for reducing rates of cardiovascular death and preventing heart attack or stroke.

Is prasugrel better than clopidogrel?

We found two trials that showed prasugrel (TRITON-TIMI 38 trial) and ticagrelor (PLATO trial) are superior to clopidogrel at reducing cardiovascular death and reducing myocardial infarction and stroke.

Is clopidogrel the same as brilinta?

Bottom Line: Brilinta (ticagrelor) appears to be slightly more effective than Plavix (clopidogrel) in reducing the percentage of CV death, MI or stroke in the first year of treatment. Brilinta patients had more breathing difficulties as a side effect compared to Plavix patients.

Is clopidogrel lifelong after stroke?

Currently, the uses of aspirin, clopidogrel, or aspirin plus extended-release dipyridamole are valid alternatives for stroke or transient ischemic attack patients. To maximize the beneficial effects of these agents, the treatment should be initiated as early as possible and continue on a lifelong basis.

Is clopidogrel the same as Plavix?

Plavix and Brilinta are both brand-name drugs. A generic form of Plavix, called clopidogrel, is available for use.

What is the difference between Plavix and baby aspirin?

Aspirin and Plavix belong to different drug classes. Plavix is an anticoagulant and aspirin is a nonsteroidal anti-inflammatory drug (NSAID). Aspirin also is used to reduce fever, and to treat pain and inflammation in the body.

How much stronger is clopidogrel than aspirin?

In the present study, the MACE rates for aspirin and clopidogrel are 30.3% and 45.4% respectively. They are substantially higher than those reported in previous studies showing the MACE rates around 10% for both antiplatelet agents [20, 21].

When do you use clopidogrel vs ticagrelor?

Importance Guidelines currently recommend ticagrelor over clopidogrel for patients with acute coronary syndrome (ACS) based on randomized clinical trial data in which ticagrelor reduced major adverse coronary events (MACE) vs clopidogrel but increased bleeding and dyspnea.

Which is better Plavix or eliquis?

Eliquis has an average rating of 5.0 out of 10 from a total of 188 ratings on Drugs.com. 33% of reviewers reported a positive effect, while 43% reported a negative effect. Plavix has an average rating of 7.6 out of 10 from a total of 57 ratings on Drugs.com.