Is there an alternative to clopidogrel?

Besides oral anticoagulants, such as warfarin and the more recent dabigatran[9], and niche agents, such as cilostazol and ticlopidine[10,11], the most promising alternatives to clopidogrel in those with background aspirin therapy are prasugrel

prasugrel

Prasugrel, sold under the brand name Effient in the US, Australia and India, and Efient in the EU) is a medication used to prevent formation of blood clots. It is a platelet inhibitor and an irreversible antagonist of P2Y₁₂ ADP receptors and is of the thienopyridine drug class. It was developed by Daiichi Sankyo Co.

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Prasugrel - Wikipedia

and ticagrelor.

Is there a better blood thinner than clopidogrel?

Brilinta has been marketed and studied as a more effective drug than Plavix. It has been shown to be a better drug for reducing rates of cardiovascular death and preventing heart attack or stroke.

Is prasugrel better than clopidogrel?

We found two trials that showed prasugrel (TRITON-TIMI 38 trial) and ticagrelor (PLATO trial) are superior to clopidogrel at reducing cardiovascular death and reducing myocardial infarction and stroke.

Can you take aspirin instead of clopidogrel?

Aspirin combined with the antiplatelet drug clopidogrel is no better than aspirin alone for stroke prevention in people with a history of lacunar strokes, and the combination carries a greater risk of gastrointestinal bleeding, according to results of a trial funded by the National Institutes of Health.

What happens if you don't take clopidogrel?

If you stop taking clopidogrel, your blood will start clotting at the same rate as before you started taking it, usually within 5 days of stopping the medicine. This means you may be at increased risk of serious problems like heart attacks or strokes.

Aggrenox generic substitute Plavix vs Aggrenox

How long can you stay on clopidogrel?

Clopidogrel and low-dose aspirin

The key question for your doctor is whether the benefits outweigh the extra risk. This combination treatment is prescribed for a limited period of time, usually up to a maximum of 12 months.

Is it safe to take clopidogrel long term?

Safety Announcement

[ 11-06-2015 ] A U.S. Food and Drug Administration (FDA) review has determined that long-term use of the blood-thinning drug Plavix (clopidogrel) does not increase or decrease overall risk of death in patients with, or at risk for, heart disease.

Is baby aspirin as effective as Plavix?

Aspirin and Plavix are more effective when taken together, but it increases the risk of bleeding. Brand names for aspirin include Bayer and Ecotrin. Aspirin is available over-the-counter (OTC) and in generic form.

What should you not take with clopidogrel?

Can you have a stroke while on clopidogrel?

Our study showed that more than half of the patients with aspirin failure were treated with clopidogrel-aspirin. In particular, a higher ESRS, which indicates an increased risk of recurrent stroke, was associated with the choice of clopidogrel-aspirin rather than aspirin.

Which is better ticagrelor or clopidogrel?

Importance Guidelines currently recommend ticagrelor over clopidogrel for patients with acute coronary syndrome (ACS) based on randomized clinical trial data in which ticagrelor reduced major adverse coronary events (MACE) vs clopidogrel but increased bleeding and dyspnea.

How do I switch from clopidogrel to ticagrelor?

clopidogrel; one can switch directly to clopidogrel maintenance dose of 75 mg daily 24 hours after the last dose of prasugrel. ticagrelor; one can switch directly to ticagrelor maintenance dose of 90 mg twice daily 24 hours after the last dose of prasugrel.

Is clopidogrel and Plavix the same?

Plavix and Brilinta are both brand-name drugs. A generic form of Plavix, called clopidogrel, is available for use. However, a generic form of Brilinta is not yet available. A generic drug is an exact copy of a brand-name medication.

What is the safest blood thinner on the market?

For instance, apixaban was associated with the lowest risk of major bleeding in a 2016 study published in the journal Chest, and the lowest risk of gastrointestinal bleeding in elderly adults compared with dabigatran and rivaroxaban in a study published in the journal Gastroenterology in 2017.

What is a natural alternative to Plavix?

Ginger. Ginger is another anti-inflammatory spice that may stop blood clotting. It contains a natural acid called salicylate.

How is Xarelto different from Plavix?

Clopidogrel is a P2Y12 inhibitor, a drug class that also includes ticagrelor (Brilinta) and prasugrel (Effient). Clopidogrel is similar to ticlopidine (Ticlid) in chemical structure and in the way it works. Xarelto (rivaroxaban) is an anticoagulant (blood thinner) used to prevent and treat blood clots.

Does clopidogrel affect sleep?

The organic nitrates (isosorbide) and the antiplatelet agents (acetylsalicylic acid, clopidogrel) are among the most prescribed drugs in cardiology and are not cited as causing insomnia or sleepiness.

Can I take vitamin D with clopidogrel?

No interactions were found between clopidogrel and Vitamin D3.

What does clopidogrel do to your body?

Clopidogrel is a platelet inhibitor. It reduces the chance that a harmful blood clot will form by preventing platelets from clumping together in the blood. Clopidogrel may also increase the chance of serious bleeding in some people. This medicine is available only with your doctor's prescription.

Why is clopidogrel preferred over aspirin?

Clopidogrel is another guideline‐recommended antiplatelet agent²¹ and has been shown to be superior to aspirin in preventing composite vascular events and reducing hemorrhagic complications in a randomized controlled trial, CAPRIE (Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events).

Which is stronger aspirin or clopidogrel?

In summary, clopidogrel appears to be somewhat more effective than aspirin if one is willing to accept the unitary atherosclerosis paradigm. The gain, however, is modest: about 200 patients should use clopidogrel rather than aspirin for 1 year to prevent just one vascular event.

Why is clopidogrel preferred to aspirin?

Several clinical trials reported that clopidogrel was superior to aspirin in secondary stroke prevention by reducing the risk of major adverse cardiovascular events (MACE).

Can clopidogrel cause tiredness?

Clopidogrel may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: excessive tiredness. headache.

Does clopidogrel affect the kidneys?

Conclusions. In summary, among patients hospitalized with ACS and treated with clopidogrel, lower levels of kidney function were associated with a greater risk of death, hospitalization for AMI, and major bleeding.

Can you drink alcohol with clopidogrel?

Can I drink alcohol while taking clopidogrel? ️ Yes (within the recommended limits). Alcohol doesn't affect clopidogrel itself, but just be aware that drinking alcohol can irritate your stomach lining. This could increase the risk of getting a bleeding in the stomach.