Can antidepressants cause brain damage?

We know that antipsychotics shrink the brain in a dose-dependent manner (4) and benzodiazepines, antidepressants and ADHD drugs also seem to cause permanent brain damage (5).
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Do antidepressants affect your brain long-term?

Some believe it is unlikely that antidepressants cause any permanent changes to brain chemistry in the long-term. Evidence seems to indicate that these medications cause brain changes which only persist whilst the medication is being taken, or in the weeks following withdrawal.
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Can antidepressants cause long-term damage?

Long-term antidepressant users are risking permanent damage to their bodies, according to leading medical experts. Dr Tony Kendrick, a professor of primary care at the University of Southampton, says more urgent action needs to be taken to encourage and support long-term users to come off the medication.
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What do antidepressants actually do to the brain?

SSRIs treat depression by increasing levels of serotonin in the brain. Serotonin is one of the chemical messengers (neurotransmitters) that carry signals between brain nerve cells (neurons). SSRIs block the reabsorption (reuptake) of serotonin into neurons.
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Do antidepressants affect intelligence?

"Perhaps we should be a bit more cautious than we are at the moment, about who we use antidepressants for. We need more research." He notes, however, that SSRI's have been in use for some 25 years and there is no evidence of brain damage or a negative impact on intellectual capacity.
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Antidepressants Exposure Linked to Brain, Behavioral Abnormalities in Developing Rats



What are the negative effects of antidepressants?

SSRIs and SNRIs
  • feeling agitated, shaky or anxious.
  • feeling and being sick.
  • indigestion and stomach aches.
  • diarrhoea or constipation.
  • loss of appetite.
  • dizziness.
  • not sleeping well (insomnia), or feeling very sleepy.
  • headaches.
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Do antidepressants shorten your lifespan?

The analysis found that in the general population, those taking antidepressants had a 33 percent higher risk of dying prematurely than people who were not taking the drugs. Additionally, antidepressant users were 14 percent more likely to have an adverse cardiovascular event, such as a stroke or a heart attack.
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How long is too long to be on antidepressants?

Clinicians generally recommend staying on the medication for six to nine months before considering going off antidepressants. If you've had three or more recurrences of depression, make that at least two years.
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Is it okay to be on antidepressants for years?

Long-term—even indefinite—use of antidepressants may be the best treatment for someone with multiple past episodes of depression, especially if they have a history of suicide attempts or have residual symptoms, like sleep problems, says Dr. Potash.
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Can SSRIs permanently change brain?

Some research has suggested this type of drug aids in neuroplasticity. In other words, these drugs can affect how our minds organize and form synaptic connections. Other researchers believe this type of medication has no long-term effects on our brains once the individual stops using the drug.
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Do antidepressants cause dementia?

Certain antidepressants and bladder medications are linked to increased risk of dementia, according to new University of East Anglia research funded by Alzheimer's Society and published today in the British Medical Journal.
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Do antidepressants heal the brain?

Scientists have long known that SSRIs rapidly increase the available amount of the neurotransmitter serotonin, leading to changes that go well beyond brain chemistry: Research suggests the drugs help reverse the neurological damage associated with depression by boosting the brain's innate ability to repair and remodel ...
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Does brain fog from antidepressants go away?

These symptoms of brain fog may be short-term or ongoing as you take these medications. While antidepressants are generally intended to help with brain fog, some can cause brain fog as a side effect, depending on the medication and your unique response to it.
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What is the truth about antidepressants?

In general, antidepressants work really well, especially when used along with psychotherapy. This combination may give you better results than using either treatment alone. Most people on antidepressants say they have eventual improvements in symptoms such as sadness, loss of interest, and hopelessness.
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Is depression cured completely?

There's no cure for depression, but there are lots of effective treatments. People can recover from depression and live long and healthy lives.
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Is there an alternative to antidepressants?

Exercise. Research suggests that regular exercise may be a more effective treatment for mild depression than antidepressants. Exercise helps boost levels of chemicals called serotonin and dopamine in the brain, which can lift your mood.
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How can I get off antidepressants naturally?

Never stop "cold turkey." In many cases, the best way to stop taking most antidepressants is to slowly cut back your dose under the guidance of your doctor. This is called tapering. Tapering helps your brain adjust to the chemical changes and can help prevent discontinuation symptoms.
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How do you know when to stop antidepressants?

The longer you have taken your medication, the slower you might want to cut down. Current recommendations for reducing the dose of an antidepressant are: If treatment has lasted less than eight weeks, stop over 1-2 weeks. If a treatment has lasted 6-8 months, cut down over 6-8 weeks.
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Do antidepressants Make You Age Faster?

Surprising results among those taking antidepressants

Researchers believe this may be due to the tendency for antidepressants to relax the facial muscles, leading to more drooping than would otherwise be the case for a particular patient's chronological age.
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How do antidepressants cause death?

Antidepressants block the absorption of serotonin in these organs as well, and the researchers warn that antidepressants could increase the risk of death by preventing multiple organs from functioning properly.
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What is the strongest antidepressant?

The most effective antidepressant compared to placebo was the tricyclic antidepressant amitriptyline, which increased the chances of treatment response more than two-fold (odds ratio [OR] 2.13, 95% credible interval [CrI] 1.89 to 2.41).
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Do antidepressants cause more harm than good?

Our review supports the conclusion that antidepressants generally do more harm than good by disrupting a number of adaptive processes regulated by serotonin. However, there may be specific conditions for which their use is warranted (e.g., cancer, recovery from stroke).
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What are the signs of too much serotonin?

Signs of Too Much Serotonin
  • Confusion.
  • Increased reflexes.
  • Restlessness.
  • Hallucinations.
  • Extreme agitation.
  • Fluctuations in blood pressure.
  • Increased heart rate.
  • Nausea, vomiting, and diarrhea.
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How do you know if your antidepressant is too strong?

Signs and symptoms include:
  1. Agitation or restlessness.
  2. Insomnia.
  3. Confusion.
  4. Rapid heart rate.
  5. Dilated pupils.
  6. Loss of muscle coordination or twitching muscles.
  7. High blood pressure.
  8. Muscle rigidity.
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Can antidepressants affect memory?

Tranquilizers, antidepressants, some blood pressure drugs, and other medications can affect memory, usually by causing sedation or confusion. That can make it difficult to pay close attention to new things. Talk to your doctor or pharmacist if you suspect that a new medication is taking the edge off your memory.
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