Why is Klinefelter so tall?

From early school age, boys with Klinefelter's syndrome tend to be taller (increased leg length) because testosterone normally stops boys growing after puberty. This increase in height is maintained throughout life. Patients with Klinefelter's syndrome may have reduced coordination compared with other boys.

Are Klinefelter people tall?

Adults with Klinefelter syndrome are usually taller than nonaffected adult males, reaching a mean final height of about 185 cm (73 in). XXY males (see the image below) also have disproportionately long arms and legs. About 25% of patients have fifth-finger clinodactyly.

Can people with Klinefelter be Short?

Although one of the most characteristic features of Klinefelter syndrome is tall stature, some uncommon variants are associated with short stature (49 XXXXY, isochromosome Xq) [3–5]. To the knowledge, there are few reported cases of Klinefelter syndrome and short stature secondary to growth hormone deficiency [1, 4].

Why would having Klinefelter syndrome affect someone's height and shape?

When puberty starts and guys' bodies begin to make sex hormones, boys with Klinefelter usually don't produce as much of the male hormone testosterone. That doesn't make a guy less male, but it can affect things like penis and testicle growth, and growth of body hair and muscles.

What do people with Klinefelter look like?

Boys and teenagers

Taller than average stature. Longer legs, shorter torso and broader hips compared with other boys. Absent, delayed or incomplete puberty. After puberty, less muscle and less facial and body hair compared with other teens.

What is Klinefelter's Syndrome?

Is Klinefelter an intersex?

Therefore, according to the NZKA, not all XXY individuals will develop Klinefelter Syndrome, for the Syndrome is simply a form of male hypogonadism, caused by a lack of testosterone: thus XXY is not an intersex condition.

Are XXY male or female?

Usually, a female baby has 2 X chromosomes (XX) and a male has 1 X and 1 Y (XY). But in Klinefelter syndrome, a boy is born with an extra copy of the X chromosome (XXY). The X chromosome is not a "female" chromosome and is present in everyone. The presence of a Y chromosome denotes male sex.

What is interesting about Klinefelter syndrome?

Klinefelter syndrome results when a boy is born with at least 1 extra X chromosome. This is written as XXY. Klinefelter syndrome occurs in about 1 out of 500 to 1,000 baby boys. Women who get pregnant after age 35 are slightly more likely to have a boy with this syndrome than younger women.

Can Klinefelter have beard?

Some males with Klinefelter syndrome have the extra X chromosome only in some of their cells (mosaic Klinefelter syndrome). Man suffering from Klinefelter syndrome has significantly lower level of testosterone, which mai lead to muscle and beard loss.

Does Klinefelter syndrome make you tired?

They may have weak muscles. Many feel tired a lot of the time and sleep a great deal. Men with Klinefelter may also develop other diseases and disorders.

Does Klinefelter get acne?

Acne is very rarely seen in classic Klinefelter syndrome (47XXY). Acne is more commonly seen in other Klinefelter genetic variants 47XYY, 48XXYY.

Can you have a normal life with Klinefelter?

The XXY condition that causes Klinefelter syndrome can't be changed, but medical treatment and working with therapists can help a boy's development and lessen the condition's effects. Even without treatment, most boys with Klinefelter syndrome grow up to live productive, healthy lives.

CAN XXY have babies?

It is possible that an XXY male could get a woman pregnant naturally. Although sperm are found in more than 50% of men with KS³, low sperm production could make conception very difficult.

Are all Klinefelter's infertile?

Between 95% and 99% of XXY men are infertile because they do not produce enough sperm to fertilize an egg naturally. But, sperm are found in more than 50% of men with KS.

Why does Klinefelter have high estrogen?

The hormonal consequences of the Klinefelter karyotype is development of hypergonadotropic hypogonadism with decreased levels of androgens causing a feedback-mediated increased pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone causing a relative increase in estrogen levels, resulting in ...

What chromosome affects height?

Although major mutations or disruptions in both the CYP19 gene and the Y chromosome have been associated previously with large effects on height (1, 4, 6–8), our findings would suggest that other common variations in these two genetic regions exert less dramatic (but significant and additive) effects on adult height.

Is Klinefelter syndrome a disability?

Most males with the 47,XXY karyotype have normal intelligence. Intellectual disability occurs in males with Klinefelter syndrome variants, who have a higher number of X chromosomes. About 70% of patients have minor developmental and learning disabilities.

Can a girl have Klinefelter's syndrome?

Klinefelter syndrome affects males only; females cannot have it. Klinefelter syndrome results from a genetic abnormality in which males have an extra copy of the X chromosome.

What doctor treats Klinefelter?

If you or your son is diagnosed with Klinefelter syndrome, your health care team may include a doctor who specializes in diagnosing and treating disorders involving the body's glands and hormones (endocrinologist), a speech therapist, a pediatrician, a physical therapist, a genetic counselor, a reproductive medicine or ...

Is Klinefelter's dominant or recessive?

Klinefelter syndrome with fabry disease--a case of nondisjunction of the X-chromosome with sex-linked recessive mutation.

What is the life expectancy of Klinefelter syndrome?

Prognosis for Klinefelter Syndrome

In general, life expectancy is normal. Some research has found that life expectancy for men with the condition may be a year or two less than those without it because of other health problems linked to Klinefelter.

What is Jacob's syndrome?

Jacobs syndrome is a rare genetic abnormality in which a male receives an extra Y chromosome from his father.

What is Mosaic Klinefelter syndrome?

Klinefelter syndrome (KS) mosaicism 46,XX/47,XXY is an extremely rare disorder of sex development characterized by the presence of both ovarian and testicular tissues in the same individual.

Can Klinefelter syndrome be cured?

Currently, there is no way to remove chromosomes from cells to "cure" the XXY condition. But many symptoms can be successfully treated, minimizing the impact the condition has on length and quality of life. Most adult XXY men have full independence and have friends, families, and normal social relationships.

Does Klinefelter syndrome cause gender dysphoria?

Abstract. Introduction: An increased risk of autistic traits in Klinefelter syndrome (KS) has been reported. In addition, some studies have shown an increased incidence of gender dysphoria (GD) and paraphilia in autism spectrum disorder.