Why is it important that clopidogrel and aspirin are given as soon as an acute myocardial event has happened?

Conclusion: Aspirin combined with clopidogrel can effectively reduce the occurrence of re-thrombosis after PCI and improve the recovery of cardiac function after acute operation, moreover the safety is high.

Why is aspirin and clopidogrel used together for MI?

The combination of clopidogrel and aspirin may lower the risk for major ischemic events among patients with minor ischemic stroke or high-risk transient ischemic attack compared with aspirin alone, according to results of the POINT study.

Why is aspirin one of the most important medications in the treatment of acute myocardial infarction?

All patients with a suspected myocardial infarction should be given aspirin. It is a powerful antiplatelet drug, with a rapid effect, which reduces mortality by 20%. Aspirin, 150-300 mg, should be swallowed as early as possible.

Why is clopidogrel given in myocardial infarction?

Clopidogrel reduces the risk of death and cardiovascular complications in patients with symptomatic atherosclerotic disease, in the setting of percutaneous coronary intervention (PCI), and in patients with unstable angina or non-STEMI.

Why is aspirin administered as a first line medication in ACS?

In acute coronary syndrome, thrombotic stroke, and Kawasaki's disease, acute use of aspirin can decrease mortality and recurrence of cardiovascular events. As secondary prevention, aspirin is believed to be effective in acute coronary syndrome, stable angina, revascularization, stroke, TIA, and atrial fibrillation.

Clopidogrel - How to take | Side Effects | Things to be aware

How does aspirin and clopidogrel work?

Aspirin and clopidogrel exert their antiplatelet effects by inhibiting thromboxane A₂ production and adenosine diphosphate–induced platelet aggregation pathways, respectively. Aspirin has proven benefits in primary and secondary prevention of coronary artery disease.

How does aspirin prevent myocardial infarction?

Some chemicals in the blood trigger events that cause blood clots. When aspirin stops those chemicals, it helps slow the formation of the clots. That's important because they can clog the arteries that bring blood to heart muscle and the brain, which increases your risk of heart attack and stroke.

Is clopidogrel used for myocardial infarction?

Clopidogrel is FDA approved for the medical management of unstable angina (UA)/non-ST-segment elevation myocardial infarction (NSTEMI), ST-segment elevation myocardial infarction (STEMI) in patients receiving fibrinolytic therapy, and for secondary prevention in recent myocardial infarction (MI), recent stroke, and ...

When administering aspirin to a patient with an acute coronary syndrome you should?

You should give an aspirin unless a 325 mg aspirin was taken in the last 60 minutes. The patient may be taking a dose (81 mg) that is not strong enough for an anti- inflammatory response (though it will cause an anti-platelet response). Therefore a full strength aspirin is indicated. 6.

How does clopidogrel work in ACS?

Clopidogrel (thienopyridine) inhibits adenosine 5'-diphosphate (ADP)–dependent activation of the glycoprotein IIb/IIIa complex, a necessary step for platelet aggregation. This process results in intense inhibition of platelet function, particularly in combination with aspirin.

Why is aspirin the drug of choice to reduce the risk of strokes myocardial infarction and unstable angina?

What do we know about how aspirin works for heart conditions and stroke? A. The mechanism by which aspirin works in the treatment of heart attack and stroke is not completely understood. However, as an antiplatelet drug, we do know that aspirin help reduce platelet clumping which helps cause blockage in blood vessels.

Which of the following is an explanation for why aspirin may be prescribed to a patient at risk of coronary heart disease?

Taking aspirin helps prevent blood clots from forming in your arteries and may help lower your risk for a stroke or heart attack.

Why aspirin is used in the treatment of unstable angina?

Aspirin prevents myocardial infarction in patients with chronic stable angina and reduces mortality, reinfarction and stroke in survivors of an acute myocardial infarction.

Should clopidogrel be taken with aspirin?

Do not take aspirin for pain relief (300mg tablets) or ibuprofen while you're taking clopidogrel, unless a doctor has said it's OK. They increase the chance of bleeding. You can take paracetamol together with clopidogrel.

When do you take clopidogrel instead of aspirin?

Clopidogrel is another guideline‐recommended antiplatelet agent²¹ and has been shown to be superior to aspirin in preventing composite vascular events and reducing hemorrhagic complications in a randomized controlled trial, CAPRIE (Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events).

Can you take both aspirin and clopidogrel together?

Aspirin combined with clopidogrel has been shown to decrease the risk of cardiovascular events in patients at higher risk of cardiovascular disease, as well as in those with acute coronary syndrome.

Which treatment should you administer first to a patient who is exhibiting symptoms of acute coronary syndrome?

The primary goal of initial treatment is early reperfusion therapy through administration of fibrinolytics (pharmacological reperfusion) or PPCI (mechanical reperfusion).

What is a contraindication to the administration of aspirin for the management of a patient with acute coronary syndrome?

Absolute contraindications to aspirin therapy include documented aspirin allergy (eg, asthma or anaphylaxis), active bleeding, or a known platelet disorder. Clopidogrel is a recommended alternative for patients who cannot tolerate aspirin.

What is the action of aspirin so important?

Aspirin causes several different effects in the body, mainly the reduction of inflammation, analgesia (relief of pain), the prevention of clotting, and the reduction of fever. Much of this is believed to be due to decreased production of prostaglandins and TXA2.

What is the mechanism of action of clopidogrel?

Mechanism Of Action

Clopidogrel is an inhibitor of platelet activation and aggregation through the irreversible binding of its active metabolite to the P2Y12 class of ADP receptors on platelets.

What is the difference between aspirin and clopidogrel?

Aspirin and Plavix (clopidogrel bisulfate) are drugs used to prevent blood clots. Aspirin and Plavix belong to different drug classes. Plavix is an anticoagulant and aspirin is a nonsteroidal anti-inflammatory drug (NSAID).

When Should aspirin be used for prevention of cardiovascular events?

If you are between 40 and 70 years old, at low risk of bleeding, and thought to be at high risk of heart disease, you might benefit from aspirin. This is an area where personal preferences matter.

What is the drug of choice for myocardial infarction?

The pain of myocardial infarction is usually severe and requires potent opiate analgesia. Intravenous diamorphine 2.5–5 mg (repeated as necessary) is the drug of choice and is not only a powerful analgesic but also has a useful anxiolytic effect.

What is aspirin primary prevention?

The American College of Cardiology and American Heart Association recommend that low-dose aspirin use (75 to 100 mg/d) might be considered for the primary prevention of atherosclerotic CVD among select adults ages 40 to 70 years at higher CVD risk but not at increased risk of bleeding.

Why might a provider order aspirin ASA for a patient with a suspected myocardial infarction?

Aspirin is effective in reducing the blood clots that are blocking a coronary artery during an acute heart attack. Anyone who has already had a heart attack, or who has an increased risk of having one in the future, should always carry a few non-coated adult aspirins with them.