Why do some people get COVID worse than others?

So, why is it that some people are so badly affected by COVID when many are barely scratched by it? Age and other health conditions increase the risk of getting really sick, but a new study suggests that those who escape the worst symptoms might also have the right balance of a type of immune cells called macrophages.
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Which organ system is most often affected by COVID-19?

COVID-19 is a disease caused by SARS-CoV-2 that can trigger what doctors call a respiratory tract infection. It can affect your upper respiratory tract (sinuses, nose, and throat) or lower respiratory tract (windpipe and lungs).
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How long does COVID-19 rebound usually last?

How long will a rebound last? In the cases that have been described, rebound symptoms improved and/or positive tests became negative within 3 days for most people.
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Which groups of people are at increased risks of severe illness from COVID-19?

Among adults, the risk for severe illness from COVID-19 increases with age, with older adults at highest risk. Severe illness means that the person with COVID-19 may require hospitalization, intensive care, or a ventilator to help them breathe, or they may even die. People of any age with certain underlying medical conditions are also at increased risk for severe illness from SARS-CoV-2 infection.
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Are you still contagious 10 days after the first day of COVID-19 symptoms?

So, there is potential for people to be infectious beyond their seven-day isolation if they are still symptomatic. After ten days, most people are not infectious. Multiple studies have shown there is very little, if any, transmission after day ten, regardless of the variant.
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Here’s what we know about COVID-19’s impact on the brain



How long are you contagious after being sick with COVID-19?


Most people with COVID-19 are no longer contagious 5 days after they first have symptoms and have been fever-free for at least three days.

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How long do I need to stay in isolation if I have symptoms of COVID-19 but my symptoms are better?


If you continue to have fever or your other symptoms have not improved after 5 days of isolation, you should wait to end your isolation until you are fever-free for 24 hours without the use of fever-reducing medication and your other symptoms have improved.

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Who is most at risk for the coronavirus disease?


Older adults are at highest risk of getting very sick from COVID-19. More than 81% of COVID-19 deaths occur in people over age 65. The number of deaths among people over age 65 is 97 times higher than the number of deaths among people ages 18-29 years.

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Who is at greatest risk of infection from COVID-19?

Currently, those at greatest risk of infection are persons who have had prolonged, unprotected close contact (i.e., within 6 feet for 15 minutes or longer) with a patient with confirmed SARS-CoV-2 infection, regardless of whether the patient has symptoms.
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What groups of people may experience stigma during the COVID-19 pandemic?

Some groups of people who may experience stigma during the COVID-19 pandemic include:

• Certain racial and ethnic minority groups, including Asian Americans, Pacific Islanders, and black or African Americans;
• People who tested positive for COVID-19, have recovered from being sick with COVID-19, or were released from COVID-19 quarantine;
• Emergency responders or healthcare providers;
• Other frontline workers, such as grocery store clerks, delivery drivers, or farm and food processing plant workers;
• People who have disabilities or developmental or behavioral disorders who may have difficulty following recommendations;
• People who have underlying health conditions that cause a cough;
• People living in congregate (group) settings, such as people experiencing homelessness.

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How common is Paxlovid rebound of COVID-19?

Currently, this type of rebounding appears to be rare. In Pfizers clinical trial, 1 to 2 percent of people treated with the antiviral had a positive COVID-19 test — or an increase in the amount of virus detected — after finishing the treatment.
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What is Paxlovid for COVID-19?

Paxlovid (nirmatrelvir tablets; ritonavir tablets) is a prescription oral antiviral drug that reduces the risk of hospitalization and death for patients with mild-to-moderate COVID-19 who are at risk of disease progression and severe illness (1).
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What is COVID-19 rebound?

COVID-19 rebound is when people with COVID-19 get better, then begin to get symptoms 2-8 days after they have recovered. They may also test positive again.
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Can COVID-19 damage organs?


COVID-19 can cause lasting damage to multiple organs, including the lungs, heart, kidneys, liver and brain. SARS CoV-2 first affects the lungs through the nasal passages. When the lungs are severely affected, it can affect the heart.

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How does COVID-19 affect the heart and lungs?

SARS-CoV-2, the virus that causes COVID-19, most commonly affects the lungs but It can also lead to serious heart problems. Lung damage caused by the virus prevents oxygen from reaching the heart muscle, which in turn damages the heart tissue and prevents it from getting oxygen to other tissues.

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Can you contract COVID-19 through sexual intercourse?

Although there is currently no evidence that the COVID-19 virus transmits through semen or vaginal fluids, it has been detected in the semen of people recovering from COVID-19. We would thus recommend avoiding any close contact, especially very intimate contact like unprotected sex, with someone with active COVID-19 to minimize the risk of transmission
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Are obese people more at risk of COVID-19?

• Having obesity increases the risk of severe illness from COVID-19. People who are overweight
may also be at increased risk.
• Having obesity may triple the risk of hospitalization due to a COVID-19 infection.
• Obesity is linked to impaired immune function.

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Are smokers more likely to contract COVID-19?

Smoking cigarettes can leave smokers more vulnerable to respiratory illnesses such as COVID-19, which is why there's never been a better time to quit smoking. FDA's Every Try Counts campaign has supportive tips and tools to help smokers get closer to quitting for good.
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Are kids any more or less likely than adults to spread coronavirus?

Early studies suggested that children do not contribute much to the spread of coronavirus. But more recent studies raise concerns that children could be capable of spreading the infection.
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When is the greatest risk of respiratory complications from COVID-19 for older patients?

While every patient is different, doctors say that days five through 10 of the illness are often the most worrisome time for respiratory complications of Covid-19, particularly for older patients and those with underlying conditions like high blood pressure, obesity or diabetes.
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Does age increase the risk for serious illness from COVID-19?

Your chances of getting seriously sick with COVID-19 go up with your age. Someone who's in their 50s is at higher risk than someone in their 40s, and so on. The highest risk is in people 85 and older.
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Who is eligible for a second COVID-19 booster vaccine?

Second booster shots are available if you are aged 50 or older, if you are 12 and older and are immune-compromised, or if you got the Johnson & Johnson vaccine for your initial dose and your first booster dose. You should get this second booster only if it has been 4 months since your first booster shot.
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How long do most people continue to test positive for COVID-19?

According to the New York Times, the omicron variant of the coronavirus moves quickly, with viral levels typically peaking less than five days after the virus is first detectable. However, some people will continue to test positive for the virus even up to 14 days later.
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What do I do if I have mild symptoms of COVID-19?

If you have milder symptoms like a fever, shortness of breath, or coughing: Stay home unless you need medical care. If you do need to go in, call your doctor or hospital first for guidance. Tell your doctor about your illness.
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Can I recover at home if I have symptoms of COVID-19?


If you have a fever, cough, or other symptoms, you might have COVID-19. Most people have mild illness and are able to recover at home. If you are sick:

  • Keep track of your symptoms.
  • If you have an emergency warning sign (including trouble breathing), call 911.


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