Why are Klinefelter males tall?

From early school age, boys with Klinefelter's syndrome tend to be taller (increased leg length) because testosterone normally stops boys growing after puberty. This increase in height is maintained throughout life. Patients with Klinefelter's syndrome may have reduced coordination compared with other boys.

Are people with Klinefelter's tall?

Adults with Klinefelter syndrome are usually taller than nonaffected adult males, reaching a mean final height of about 185 cm (73 in). XXY males (see the image below) also have disproportionately long arms and legs. About 25% of patients have fifth-finger clinodactyly.

Can people with Klinefelter be Short?

Although one of the most characteristic features of Klinefelter syndrome is tall stature, some uncommon variants are associated with short stature (49 XXXXY, isochromosome Xq) [3–5]. To the knowledge, there are few reported cases of Klinefelter syndrome and short stature secondary to growth hormone deficiency [1, 4].

Why would having Klinefelter syndrome affect someone's height and shape?

When puberty starts and guys' bodies begin to make sex hormones, boys with Klinefelter usually don't produce as much of the male hormone testosterone. That doesn't make a guy less male, but it can affect things like penis and testicle growth, and growth of body hair and muscles.

Do all people with Klinefelter syndrome have small testes?

Symptoms of Klinefelter syndrome vary between individuals and include a range of physical features, such as tall stature, breast development (gynecomastia) and behavioural and learning difficulties. Small testes are present in almost all men with Klinefelter syndrome.

What is Klinefelter's Syndrome?

Does Klinefelter get acne?

Acne is very rarely seen in classic Klinefelter syndrome (47XXY). Acne is more commonly seen in other Klinefelter genetic variants 47XYY, 48XXYY.

Can people with Klinefelter syndrome grow beard?

Some males with Klinefelter syndrome have the extra X chromosome only in some of their cells (mosaic Klinefelter syndrome). Man suffering from Klinefelter syndrome has significantly lower level of testosterone, which mai lead to muscle and beard loss.

What chromosome affects height?

Although major mutations or disruptions in both the CYP19 gene and the Y chromosome have been associated previously with large effects on height (1, 4, 6–8), our findings would suggest that other common variations in these two genetic regions exert less dramatic (but significant and additive) effects on adult height.

Can males with Klinefelter syndrome have babies?

Most boys with Klinefelter syndrome can have sex when they become men, usually with the help of testosterone treatment. But problems with their testicles prevent them from making enough normal sperm to father children. Most men with the condition are infertile and can't father a child the usual way.

CAN XXY be female?

Usually, a female baby has 2 X chromosomes (XX) and a male has 1 X and 1 Y (XY). But in Klinefelter syndrome, a boy is born with an extra copy of the X chromosome (XXY). The X chromosome is not a "female" chromosome and is present in everyone.

What is the common physical characteristics of people with Klinefelter syndrome?

Taller than average stature. Longer legs, shorter torso and broader hips compared with other boys. Absent, delayed or incomplete puberty. After puberty, less muscle and less facial and body hair compared with other teens.

How common is Klinefelters?

Klinefelter syndrome is common, affecting one in every 450 men. But most people with Klinefelter syndrome don't know they have it and have never received treatment. It is also known as Klinefelter's syndrome and as XXY syndrome.

Is Klinefelter an intersex?

Other intersex conditions, including the last four conditions listed above—complete androgen insensitivity, Klinefelter syndrome, Turner syndrome, and vaginal agenesis—usually do not result in ambigu- ous genitals and may not be recognized at birth.

What is interesting about Klinefelter syndrome?

Klinefelter syndrome results when a boy is born with at least 1 extra X chromosome. This is written as XXY. Klinefelter syndrome occurs in about 1 out of 500 to 1,000 baby boys. Women who get pregnant after age 35 are slightly more likely to have a boy with this syndrome than younger women.

Why does Klinefelter have high estrogen?

The hormonal consequences of the Klinefelter karyotype is development of hypergonadotropic hypogonadism with decreased levels of androgens causing a feedback-mediated increased pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone causing a relative increase in estrogen levels, resulting in ...

Are all Klinefelter's infertile?

Between 95% and 99% of XXY men are infertile because they do not produce enough sperm to fertilize an egg naturally. But, sperm are found in more than 50% of men with KS.

Does Klinefelter syndrome make you tired?

They may have weak muscles. Many feel tired a lot of the time and sleep a great deal. Men with Klinefelter may also develop other diseases and disorders.

Does Klinefelter syndrome affect mental health?

Patients with Klinefelter syndrome have a higher burden of psychiatric conditions, especially depression, anxiety, schizophrenia and psychosis, than the general population. Adolescents are described as being sensitive, introspective and unassertive.

Is Klinefelter syndrome fatal?

Prognosis for Klinefelter Syndrome

In general, life expectancy is normal. Some research has found that life expectancy for men with the condition may be a year or two less than those without it because of other health problems linked to Klinefelter.

Does testosterone increase height?

Though testosterone is not a growth hormone, it does stimulate the production of HGH and IGF-1. This is why high testosterone levels can lead to an increase in height, especially during puberty.

What gene makes you tall?

In addition to the FGFR3 gene, researchers have identified hundreds of other genes involved in rare disorders that have an extreme effect on height.

Do taller guys have less testosterone?

... Data on healthy and physically active men from western population demonstrate significant relationship between male stature and the change in testosterone levels, and no link between body height and circulating testosterone levels in general.

Is Klinefelter syndrome a disability?

Most males with the 47,XXY karyotype have normal intelligence. Intellectual disability occurs in males with Klinefelter syndrome variants, who have a higher number of X chromosomes. About 70% of patients have minor developmental and learning disabilities.

Does Klinefelter cause hair loss?

It is the most common human sex chromosome disorder, with a prevalence of 1 in 500 males. Signs of KS include low testosterone levels (63–85%), increased prepubertal and adult height (30%), reduced muscle mass, decreased facial hair (60–80%), and decreased pubic hair (30–60%) [8].

Is Klinefelter's dominant or recessive?

Klinefelter syndrome with fabry disease--a case of nondisjunction of the X-chromosome with sex-linked recessive mutation. Heart Lung Circ. 2014 Dec;23(12):1149-52.