Who gets Paget's disease of the breast?

Paget disease of the breast occurs in both women and men, but most cases occur in women. Approximately 1 to 4 percent of all cases of breast cancer also involve Paget disease of the breast. The average age at diagnosis is 57 years, but the disease has been found in adolescents and in people in their late 80s (2, 3).

Who is most likely to get Paget's disease?

How rare is Paget's disease of the breast?

Paget's disease of the breast is a rare type of cancer that forms in or around your nipple. It's involved in 1% to 4% of all breast cancers. It may be linked with an underlying breast cancer, either ductal carcinoma in situ or invasive breast cancer.

What is the most common age for females to be diagnosed with Paget's disease?

Paget's disease of the breast occurs most often after age 50. Most people with this diagnosis also have underlying ductal breast cancer, either in situ — meaning in its original place — or, less commonly, invasive breast cancer. Only rarely is Paget's disease of the breast confined to the nipple itself.

Is Pagets disease hereditary?

Inheritance. In 15 to 40 percent of all cases of classic Paget disease of bone, the disorder has an autosomal dominant pattern of inheritance. Autosomal dominant inheritance means that having one copy of an altered gene in each cell is sufficient to cause the disorder.

Paget's Disease Of The Breast, What Is It?

Does vitamin D deficiency cause Paget's disease?

Prevalence of vitamin D deficiency is higher in patients with Paget's disease of bone compared with age-matched controls. Arq Bras Endocrinol Metabol. 2013 Oct;57(7):509-12. doi: 10.1590/s0004-27302013000700002.

What environmental factors cause Paget's disease?

Can mammogram detect Paget's disease?

Paget's disease of the breast is misdiagnosed due to the fact that it presents itself in a way that resembles eczema. Unless the physician is familiar with the disease, they do not know what to look for. It does not show up on a typical mammogram or ultrasound.

How do you know if you have Paget's disease of the breast?

Symptoms of Paget's disease of the nipple

Paget's disease of the nipple always starts in the nipple and may extend to the areola. It appears as a red, scaly rash on the skin of the nipple and areola. The affected skin is often sore and inflamed, and it can be itchy or cause a burning sensation.

How can you prevent Paget's disease of the breast?

Can Paget's disease be prevented?

Unfortunately, there's nothing you can do to prevent Paget's disease of the bone. There are some things that are considered risk factors for developing Paget's disease of the bone, including: Your age: People over the age of 50 are more likely to develop Paget's disease of the bone.

How quickly does Pagets disease progress?

Mammary Paget's disease is associated with carcinoma of the underlying lactipherous ducts. The skin lesions progress slowly over months as scaly, fissured, or oozing erythema of the nipple and areola. Advanced lesions may appear as well-demarcated, eczema-like plaques with a pink or red hue.

Can an 18 year old get Paget's disease?

It is extremely uncommon in young women. The presenting age ranges from 24 to 84 years with a mean age at diagnosis being 55 years [6]. This is one of the few reports in the literature of a woman presenting at a young age with Paget's disease of the breast, and this patient represents the third youngest such woman.

What is the life expectancy of someone with Paget's disease?

In that study, the British General Practice Research Database identified 2465 patients diagnosed with Paget's disease of bone from 1988 to 1999; retrospective review indicated that 5-yr survival was 67% in patients with Paget's disease compared with 72% in control patients.

Does Paget's disease affect both breasts?

Early on, the skin symptoms of Paget's disease of the breast may fluctuate, improving only to worsen again. Paget's disease of the breast usually affects one breast (unilateral), but there are rare cases in which both breasts are involved (bilateral).

Can you survive Paget's disease of the breast?

According to NCI's Surveillance, Epidemiology, and End Results program, the 5-year relative survival for all women in the United States who were diagnosed with Paget disease of the breast between 1988 and 2001 was 82.6 percent.

Is Paget's disease serious?

Over time, enlarged or misshapen bones can stress nearby joints leading to osteoarthritis in those joints. In very rare cases, Paget's can turn into a life-threatening cancerous bone disease. Severe Paget's disease may cause damage to the heart.

How do you check for Paget's disease?

X-ray and bone scan

An X-ray can show whether your bones have become enlarged as a result of Paget's disease of bone. Sometimes a bone scan called scintigraphy may also be carried out to check how much of your body is affected by the condition.

Is Paget's disease an autoimmune disease?

Paget's disease of bone is a chronic autoimmune inflammatory disease that leads to an increase in bone reabsorption. While depression is extensively described in Paget's disease, affecting up to 50% of patients, the prevalence of manic episodes is unknown.

What foods are good for Paget's disease?

Is Pagets disease painful?

Bone pain. Bone pain caused by Paget's disease is usually: dull or aching. deep within the affected part of the body.

What are the long term effects of Paget's disease?

If Paget's disease of bone affects the skull, there's a significant risk that it could lead to permanent hearing loss and possibly total deafness. This can occur as a result of damage to the bones or nerves that connect the ears to the brain.

Is it normal for a teenage girl to have a lump in her breast?

If you feel a lump in your breast, don't panic — breast cancer is extremely rare in teens. For teen girls, the most common type of breast lump is usually just part of normal breast growth. Lots of girls and women have something called fibrocystic breast changes.

Do you need chemo for Paget's disease?

After your operation, your doctor may recommend additional treatment (adjuvant therapy) with anti-cancer drugs (chemotherapy), radiation therapy or hormone therapy to prevent a recurrence of breast cancer.

Does exercise help Paget's disease?

Physical therapy (PT) can play an important role in the treatment process and rehabilitation of patients with Paget disease by helping to maintain or improve muscle strength, maintain joint range of motion (ROM) and flexibility, increase endurance, and avoid deconditioning.