Who gets ALS the most?

Most people who develop ALS are between the ages of 40 and 70, with an average age of 55 at the time of diagnosis. However, cases of the disease do occur in people in their twenties and thirties. ALS is 20% more common in men than women.
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Who is most at risk for ALS?

Age. ALS risk increases with age, and is most common between the ages of 40 and the mid-60s. Sex. Before the age of 65, slightly more men than women develop ALS .
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What are my chances of having ALS?

The incidence of sporadic ALS shows little variation in the Western countries, ranging from 1 to 2 per 100,000 person-years,1518 with an estimated lifetime risk of 1 in 400. ALS is rare before the age of 40 years and increases exponentially with age thereafter.
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Can ALS be prevented?

There is no definite method to prevent ALS. However, people with ALS can participate in clinical trials, the National ALS Registry, and the National ALS Biorepository. This participation may help researchers learn about potential causes and risk factors of the disease.
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What race is more prone to ALS?

Some studies suggest that ALS rates are higher among non-Hispanic Caucasians (whites) in Western countries compared with those of African, Asian, and Hispanic descent (minorities) (9–13).
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Roger's story: ALS research at Washington University School of Medicine



Why is ALS becoming more common?

Here we show that the number of ALS cases across the globe will increase from 222,801 in 2015 to 376,674 in 2040, representing an increase of 69%. This increase is predominantly due to ageing of the population, particularly among developing nations.
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How did Stephen Hawking get ALS?

While in Cambridge, his father took him to the family physician who sent him to the hospital for tests after his 21st birthday. Stephen Hawking told the British Medical Journal that this motor neuron disease has many potential causes, and that his ailment might be due to an inability to absorb vitamins [1].
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What are the 1st signs of ALS?

Early symptoms include:
  • Muscle twitches in the arm, leg, shoulder, or tongue.
  • Muscle cramps.
  • Tight and stiff muscles (spasticity)
  • Muscle weakness affecting an arm, a leg, the neck, or diaphragm.
  • Slurred and nasal speech.
  • Difficulty chewing or swallowing.
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Can anxiety cause ALS symptoms?

Psychological stress does not appear to play a part in the development of amyotrophic lateral sclerosis (ALS), with patients showing similar levels of prior stressful events, occupational stress, and anxiety as a control group, as well as higher resilience, a study shows.
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Can poor diet cause ALS?

Approximately 90% of ALS cases are sporadic, suggesting there are multiple contributing factors that influence the disease risk, onset, and progression. Diet and sex are two factors that have been reported to alter ALS risk, onset and progression in humans and in animal models, providing potential modifiers of disease.
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What age does ALS usually start?

Most people who develop ALS are between the ages of 40 and 70, with an average age of 55 at the time of diagnosis. However, cases of the disease do occur in people in their twenties and thirties. ALS is 20% more common in men than women.
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Can you have ALS for years and not know it?

It is extremely difficult to diagnose ALS. In fact, it's often diagnosed months or even years after symptoms begin, by ruling out other diseases. It's crucial to seek a neurologist with experience in ALS and/or neuromuscular diseases if you or someone if you or a loved one are showing symptoms.
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Where does ALS usually start?

The earliest signs of ALS usually include muscle weakness or stiffness (spasticity). ALS typically affects all muscles under voluntary control, and the person ultimately loses their strength and ability to eat, speak, grasp things, move and even breathe.
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What lifestyle factors cause ALS?

Common environmental factors suspected of contributing to ALS include ethnicity, geographic location, diet and nutrition, exercise and sports, alcohol or tobacco use, occupation, electric shock, exposure to chemicals or radiation, and concussion or other physical injury ("trauma").
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Can alcohol contribute to ALS?

The findings in the association between alcohol consumption and ALS are inconsistent; a recent population-based study suggests that drinking alcohol does not seem to influence the risk of developing ALS [40].
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Is ALS more common in athletes?

The study was also the first to investigate ALS incidence by including living players with ALS in the analysis and found that professional players are 3.6 times more likely to develop ALS than the general population.
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What can mimic ALS symptoms?

A number of disorders may mimic ALS; examples include:
  • Myasthenia gravis.
  • Lambert-Eaton myasthenic syndrome.
  • Lyme disease.
  • Poliomyelitis and post-poliomyelitis.
  • Heavy metal intoxication.
  • Kennedy syndrome.
  • Adult-onset Tay-Sachs disease.
  • Hereditary spastic paraplegia.
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Can ALS be caused by emotional trauma?

Findings were that high stress, a type A personality, and physical activity were present more often in people with ALS.
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Can depression cause ALS?

Depression and the subsequent risk of ALS.

Within 1 year after depression diagnosis, there was a 3.6-fold risk of ALS. Higher risk of ALS was also noted for the second and third years after depression diagnosis (table 3). The same pattern was seen for antidepressant use and “any depression” (table 3).
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What does ALS pain feel like?

common feature of ALS.1

Joint pain and stiffness can occur because of lack of movement and use of one's limbs. For many, joint pain can be alleviated by moving around and not sitting in the same position for a long length of time. Those who are immobile should have a caretaker assist with movement exercises.
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What is the longest someone has lived with ALS?

Astrophysicist Stephen Hawking, whose ALS was diagnosed in 1963, had the disease for 55 years, the longest recorded time one had the disease. He died at the age of 76 in 2018.
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Is als a painful death?

There is no reason that people with ALS have to live in pain. Although only a limited number of people with ALS experience pain, the thought of living with constant pain can be frightening. The disease itself does not cause pain.
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Are we close to a cure for ALS?

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects as many as 30,000 people in the United States, with 5,000 new cases diagnosed each year. It weakens muscles over time, impacting physical function and ultimately leading to death. There is no single cause for the disease and no known cure.
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What were Stephen Hawkings first symptoms of ALS?

Professor Hawking had just turned 21 when he was diagnosed with a very rare slow-progressing form of ALS, a form of motor neurone disease (MND). He was at the end of his time at Oxford when he started to notice early signs of his disease. He was getting more clumsy and fell over several times without knowing why.
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Is ALS always fatal?

ALS is fatal. The average life expectancy after diagnosis is two to five years, but some patients may live for years or even decades.
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