Which is the first line treatment for Paget's disease?

Bisphosphonates are first-line therapy for Paget's disease, and the advent of the new bisphosphonates permits a dramatic improvement in treatment. The optimal treatment regimen should obtain normalisation or quasi-normalisation of markers of bone remodelling.

Which of the following medication is appropriate to treat Paget's disease?

Osteoporosis drugs (bisphosphonates) are the most common treatment for Paget's disease of bone. Bisphosphonates are typically given by injection into a vein, but they can also be taken by mouth. When taken orally, bisphosphonates are generally well tolerated but can irritate the stomach.

Is there any treatment for Paget's disease?

There's currently no cure for Paget's disease of bone, but treatment can help relieve the symptoms. If you do not have any symptoms, your doctor may suggest keeping an eye on your condition and delaying treatment until any problems occur.

What is the infusion for Paget's disease?

A single infusion of zoledronic acid is safe and effective for the treatment of Paget's disease. Oral bisphosphonates, which are currently used for the treatment of Pagets disease, are given to patients daily for 2–6 months.

What do bisphosphonates do for Pagets disease?

Nitrogen-containing bisphosphonates are among the first line medications being used to treat Paget's disease of bone. They suppress disease activity by reducing osteoclast-mediated bone resorption and bone turnover, which is reflected by the reduction or normalization of the raised serum ALP level.

Paget’s Disease of Bone (Osteitis Deformans) | Causes, Pathogenesis, Symptoms, Diagnosis

Is calcitonin used for Paget disease?

Salmon calcitonin is a highly effective therapeutic agent in the treatment of Paget's disease. During chronic treatment with salmon calcitonin, alkaline phosphatase activity and urinary hydroxyproline excretion decrease on an average of 50% in patients with Paget's disease.

What does calcitonin do for a person with Paget's disease?

Human calcitonin has proven to be an effective drug in the management of Paget's disease. Bone pain decreased in a high percentage of cases and biochemical indices improved in all but a few instances. Radiologic regression of the disease often was seen after several years of treatment.

Should I take Zometa?

Results from three studies all suggest that Zometa can help reduce the risk of cancer recurrence when it's started right after surgery to treat hormone-receptor-positive early-stage breast cancer in postmenopausal and older premenopausal women.

What is zoledronate infusion?

Aclasta. Zoledronic acid is an osteoporosis medication prescribed to help strengthen your bones and reduce your risk of breaking a bone. It is available as an annual intravenous infusion (drip). Zoledronic acid is a 'bisphosphonate' - a group of medications that work by slowing down the cells that break down bone.

How many years can reclast be given?

After 3 to 5 years, your healthcare provider may stop your Reclast prescription and prescribe a different osteoporosis treatment. That's because studies of Reclast are only based on 3 years of treatment.

Which of the following is helpful in the diagnosis of Paget's disease?

A blood test may reveal elevated levels of the enzyme alkaline phosphatase suggesting the diagnosis of Paget's disease, usually confirmed by x-ray. A bone scan may also be used to determine the extent of the abnormalities in the bones.

What specialist manages Paget's disease?

Paget's disease can affect many parts of the body. You may need to see more than one type of doctor, including: Endocrinologists, who treat hormonal and metabolic disorders. Rheumatologists, who treat joint and muscle disorders.

What kind of drugs are bisphosphonates?

Bisphosphonates are a group of medicines that slow down or prevent bone loss, strengthening bones. Bisphosphonates inhibit osteoclasts which are responsible for breaking down and reabsorbing minerals such as calcium from bone (the process is known as bone resorption).

Which of the following medications used in Paget's disease which facilitates remodeling of abnormal bone?

Bisphosphonates: The treatment of choice for management of Paget's disease is a bisphosphonate. Bisphosphonates improve bone formation by slowing bone turnover and inhibiting osteoclast activity.

How do bisphosphonates work?

Bisphosphonates are drugs that target areas of higher bone turnover. The osteoclast cells, which break down old bone, absorb the bisphosphonate drug. Their activity is slowed down. This reduces bone breakdown.

What is the most common presenting symptom of Paget disease?

When symptoms occur, the most common complaint is bone pain. Because this disease causes your body to generate new bone faster than normal, the rapid remodeling produces bone that's less organized and weaker than normal bone, which can lead to bone pain, deformities and fractures.

Who should not take zoledronic acid?

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, dehydration, aspirin-sensitive asthma. Some people using zoledronic acid may have serious jawbone problems. Your doctor should check your mouth before you start this medication.

Is zoledronic acid Safe?

Zoledronic acid had an acceptable safety profile; no adverse events were considered to be drug related. Treatment with ZA improved bone health by enhancing bone mineral density and reducing bone turnover, even in high-risk patients.

Is zoledronic acid the same as Zometa?

Zoledronic acid is a type of drug known as a bisphosphonate. It has the brand name Zometa. It reduces the risk of fractures in cancers that affect the bones, such as: myeloma.

Is there an alternative to Zometa?

A study has found that Xgeva (chemical name: denosumab), a targeted therapy medicine, is better than Zometa at reducing the risk of a skeletal-related event in women diagnosed with metastatic breast cancer that has spread to the bones. The study also found Xgeva improved quality of life more than Zometa.

Which is better prolia or Zometa?

Prolia has an average rating of 2.7 out of 10 from a total of 322 ratings on Drugs.com. 14% of reviewers reported a positive effect, while 79% reported a negative effect. Zometa has an average rating of 4.5 out of 10 from a total of 39 ratings on Drugs.com.

What are the long term side effects of Zometa?

Where do you give calcitonin injection?

This medicine is given as a shot under your skin or into one of your muscles. Calcitonin injection may be given at home to patients who do not need to be in the hospital.

Why is calcium and phosphate normal in Paget's disease?

Calcium and phosphate — The breakdown and buildup of bone is essential in regulating the levels of calcium and phosphorus in the blood. In most people with Paget disease, these levels remain normal. (See "Patient education: Primary hyperparathyroidism (Beyond the Basics)".)

Is calcitonin still used?

Calcitonin is currently FDA approved for use in postmenopausal osteoporosis once the patient is at least five years postmenopausal. [1] By inhibiting osteoclasts, mitigation of bone mineral density (BMD) losses can occur, and the risk of osteoporotic fractures decreased.