Which COVID-19 vaccines are based on mRNA technology?

The Pfizer-BioNTech and Moderna COVID-19 vaccines are messenger RNA vaccines, also called mRNA vaccines.
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What COVID-19 vaccines are using mRNA technology?


The vaccines made by Pfizer-BioNTech and Moderna use mRNA to fight COVID-19.

When these vaccines were rolled out, it was the first time mRNA was used on humans in vaccine technology. While the concept is new to the public, the research has been around since the early 1990s. What are mRNA Vaccines? 2/11

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Who developed the mRNA technology for the COVID-19 vaccine?


Two Penn researchers, Katalin Karikó, PhD, and Drew Weissman, MD, PhD, invented messenger RNA (mRNA) technology that serves as the foundation of the Pfizer/BioNTech and Moderna vaccines.

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Is there a difference between the Moderna COVID-19 booster and Moderna third shot?


In the case of Moderna, the booster dose is only half of the original dose. Unlike boosters, third/additional doses of COVID-19 vaccines are for people who received the complete starter series of vaccines but then their immune systems didn't have a good enough response.

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Are there any safety concerns concerning mRNA technology of the Pfizer-BioNTech COVID-19 Vaccine?

FDA does not have specific safety concerns with a vaccine that utilizes this technology.

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Are mRNA COVID-19 vaccines safe?


mRNA vaccines are safe and effective.
mRNA vaccines have been held to the same rigorous safety and effectiveness standards as all other types of vaccines in the United States.

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Do mRNA COVID-19 vaccines cause heart inflammation?


These cases typically occur in male adolescents and young adults after the second dose, and within a week of vaccination. It is important to seek medical care if symptomatic (chest pain, shortness of breath, having a fast beating, fluttering, or pounding heart).

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Can you mix and match COVID-19 booster shots?

The FDA has authorized the use of mix-and-match booster doses for currently available COVID-19 vaccines based on the results of a NIAID-supported study.

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When should you usually get a COVID-19 booster vaccine?

1st Booster: Most people, at least 5 months after the final dose in the primary series. People who are moderately or severely immunocompromised, at least 3 months after the final dose in the primary series.
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Do COVID-19 boosters use the same ingredients as existing vaccines?

Yes. COVID-19 boosters are the same ingredients (formulation) as the current COVID-19 vaccines. However, in the case of a Moderna COVID-19 vaccine booster, the dose is half of the amount of the vaccine people get for their primary series.

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Who makes Moderna's COVID-19 vaccine?


Manufacturer: ModernaTX, Inc.

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How does the Johnson and Johnson COVID-19 vaccine work?


The J&J/Janssen COVID-19 vaccine also contains a piece of a modified virus that is not the virus that causes COVID-19. This modified virus is called the vector virus. The vector virus cannot reproduce itself, so it is harmless. This vector virus gives instructions to cells in the body to create an immune response.

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Can you contract COVID-19 through sexual intercourse?

Although there is currently no evidence that the COVID-19 virus transmits through semen or vaginal fluids, it has been detected in the semen of people recovering from COVID-19. We would thus recommend avoiding any close contact, especially very intimate contact like unprotected sex, with someone with active COVID-19 to minimize the risk of transmission
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What are the severe allergic reactions to COVID-19 mRNA vaccines?


“Overall, severe allergic reactions to COVID-19 mRNA vaccines, including life-threatening anaphylaxis reactions such as low blood pressure and difficulty breathing, are rare, on the order of five cases per million vaccine doses administered,” noted Dr. Guerrerio.

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Are severe reactions to mRNA COVID-19 vaccines common?


We found that reported reactions to mRNA vaccination were mostly mild in severity and transient in duration, and most reports were non-serious. Reactions and health impacts were reported more frequently in female than in male recipients, and in individuals younger than 65 years than in older individuals.

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Is it safe to take the Moderna, Pfizer-BioNTech, or J&J COVID-19 vaccine during pregnancy?

No safety concerns were found in animal studies: Studies in animals receiving a Moderna, Pfizer-BioNTech, or Johnson & Johnson (J&J)/Janssen COVID-19 vaccine before or during pregnancy found no safety concerns in pregnant animals or their babies.
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When do you get the second COVID-19 vaccine?

If you receive a vaccine that requires two doses, you should get your second shot as close to the recommended interval as possible. However, your second dose may be given up to 6 weeks (42 days) after the first dose, if necessary.. You should not get the second dose earlier than the recommended interval.
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Who should get a COVID-19 booster?


Everyone ages 5 years and older should get 1 booster after completing their COVID-19 vaccine primary series.

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What is the dosing interval for Pfizer-BioNTech COVID-19 vaccine?


The Pfizer-BioNTech COVID-19 vaccine is FDA-approved for use as a two-dose series administered 21 days apart to adolescents and adults 16 years and older and is authorized for emergency use in children ages 12-15 using the same schedule.

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Can you mix and match the vaccines for your mRNA (Pfizer or Moderna) primary vaccination series?


No, vaccines used for the primary vaccination series should be same. However, if the mRNA vaccine product given for the first two doses is not available or is unknown, either Pfizer-BioNTech or Moderna COVID-19 vaccine (mRNA COVID-19 vaccines) may be administered.

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How long does COVID-19 rebound usually last?

How long will a rebound last? In the cases that have been described, rebound symptoms improved and/or positive tests became negative within 3 days for most people.
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How long does COVID-19 rebound last?

So far there have been no reports of severe illness in those who have experienced covid rebound, and most people seem to recover and stop testing positive around three days later without needing additional covid-19 treatment.
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What are the symptoms of myocarditis from the COVID-19 vaccine?


What are the symptoms of myocarditis and pericarditis? Symptoms include chest pain, palpitations (the feeling of one's heart beating very fast), and shortness of breath. If your child develops any of these symptoms after receiving the COVID-19 vaccine, please contact your pediatrician and seek medical care.

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What are the average ages of people who had myocarditis after mRNA-based COVID-19 vaccination during the first 8 months of 2021?

Of the 1626 reports that met the CDCs case definition for myocarditis, 1195 (73%) were younger than 30 years of age, 543 (33%) were younger than 18 years of age, and the median age was 21 years (IQR, 16-31 years) (Figure 1).
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Can COVID-19 cause heart inflammation?


Viruses are a common cause of heart inflammation – known as myocarditis – and the coronavirus is no different. The Centers for Disease Control and Prevention reported in September research showing patients with COVID-19 had nearly 16 times the risk of myocarditis compared with patients without COVID-19.

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