Which calcium channel blocker causes the least amount of swelling?

Diltiazem, a non-DHP agent, seems to be associated with the lowest incidence of ankle oedema.

Which calcium channel blocker causes less swelling?

Edema will diminish upon conversion from a dihydropyridine CCB to a nondihydropyridine CCB such as verapamil or diltiazem. In addition, the newer, third-generation dihydropyridine CCBs such as lacidipine,^[32,33] manidipine, and lercanidipine^{[32,33,34,35]} are regularly reported to cause less peripheral edema.

Do calcium channel blockers cause swelling?

Objective: Peripheral edema is considered to be a common and annoying adverse effect of calcium channel blockers (CCBs). It has been thought to occur secondary to arteriolar dilatation causing intracapillary hypertension and fluid extravasation.

What calcium blocker has the least side effects?

Which is the best calcium channel blocker?

Dihydropyridine calcium-channel blockers

For people with hypertension alone, amlodipine may be preferred on the basis of cost. For people with hypertension and angina, amlodipine, felodipine, and modified-release nifedipine may be preferred.

Calcium Channel Blockers: Key side-effects in 90 seconds

Which is better diltiazem or amlodipine?

Although both agents were well tolerated and reduced blood pressures consistently over the 10-week test period, amlodipine was more effective than diltiazem in reducing systolic and diastolic blood pressures to the target pressures of < 140 mm Hg systolic and < 90 mm Hg diastolic over a range of doses widely used in ...

What is the newest calcium channel blocker?

Cilnidipine is a recently developed CCB, and possesses both L- and N-type calcium channel blocking activity [23]. Since N-type calcium is distributed along the nerve and in the brain, cilnidipine is anticipated to exert specific action on nerve activity, such as inhibition of the sympathetic nervous system.

How do I reduce swelling from amlodipine?

Ways to reduce swelling from amlodipine include: Non-pharmacological interventions, such as using a footstool to raise your legs as often as possible; regularly doing foot exercises to promote better movement and circulation.

Which is better amlodipine or felodipine?

Amlodipine seems to be more effective than felodipine when the drugs are compared in the same dose, with regard to the effect on clinic BP 24 h after dosing and to ambulatory BP during the night. The longer elimination half-life of amlodipine as compared to felodipine is the probable reason for this finding.

What is the best alternative to amlodipine?

Which calcium channel blocker causes the most edema?

Pedal edema is one of the most common adverse effects of calcium antagonists. It has been observed with all available dihydropyridine agents, but it also seems to occur to a lesser extent with verapamil and diltiazem.

Should I stop taking amlodipine cause my feet swell?

In those taking higher dose (10mg) amlodipine, about 10 people in every 100 reported leg swelling (10%). Interestingly, women are more likely to get the swelling, and most people tolerate this well and do not have to discontinue the medication.

Does Cardizem cause ankle swelling?

Common side effects include swollen hands, ankles or feet, headaches and constipation. Diltiazem starts to work on the day you start taking it, but for high blood pressure and angina it may take a couple of weeks to work fully.

Does diltiazem cause leg swelling?

rash, edema (swelling of the legs and feet with fluid), low blood pressure (hypotension), drowsiness, and.

Does amlodipine cause ankle swelling?

Amlodipine (Norvasc) is a medication used to lower blood pressure. The higher the dose, the more likely you are to have swelling in both of your legs and feet. One in 10 patients experience swelling when taking amlodipine at a dose of 10 mg daily.

Does verapamil cause ankle swelling?

Many people using this medication do not have serious side effects. Tell your doctor immediately if any of these unlikely but serious side effects occur: swelling ankles/feet, shortness of breath, unusual tiredness, unexplained/sudden weight gain, severe dizziness, fainting, very slow heartbeat.

Does felodipine have less side effects than amlodipine?

Amlodipine appears to be more potent on a milligram to milligram basis and induces fewer side-effects than does felodipine ER.

Does felodipine cause bloating?

This medicine may cause fluid retention (edema) in some patients. Tell your doctor right away if you have bloating or swelling of the face, arms, hands, lower legs, or feet; tingling of the hands or feet; or unusual weight gain or weight loss.

Why does felodipine cause Oedema?

It is concluded that oedema formation induced by felodipine and other calcium antagonists can partly be ascribed to the vasodilatory effect of the drug (increased capillary pressure) and partly to interference with the local vascular control (probably the myogenic component) that protects dependent vascular regions ...

What is difference between amlodipine and S amlodipine?

Amlodipine is a member of the dihydropyridine class of calcium channel blockers and can be used as monotherapy or in combination with other antihypertensive drugs for the treatment of hypertension. S-amlodipine is a vasoactive enantiomer of amlodipine.

Which blood pressure tablets cause swollen ankles?

Calcium channel blockers, which help to manage blood pressure, are a common cause, especially a type called dihydropyridines. The drug amlodipine is an example. Some swelling of the feet and ankles occurs in almost half the people who take calcium channel blockers.

Why does Norvasc cause swelling?

Cause. Edema commonly occurs with calcium channel blockers because the drugs trigger the dilation of blood vessels. The dilation, in turn, lowers the blood pressure and improves the flow of blood throughout the body.

Does amlodipine cause edema?

Amlodipine and nifedipine are common drugs associated with vasodilatory edema. When used as monotherapy, calcium channel blockers (CCBs) are associated with a substantial risk of peripheral edema, including pedal edema, which is the most common reason for its discontinuation.

Which is better amlodipine or cilnidipine?

Both amlodipine and cilnidipine have equal efficacy in reducing blood pressure in hypertensive individuals. But cilnidipine being N-type and L-type CCB, associated with lower incidence of pedal edema compared to only L-type channel blocked by amlodipine.

Who should not take calcium channel blockers?

Here are some things to consider if you and your doctor are deciding whether you should take a calcium channel blocker. You have allergies to foods or dyes. You are thinking of becoming pregnant, you are pregnant, or you are breast-feeding your baby. You are over 60.