What was Karev's last scene?

On January 10, 2020, it was announced that Chambers left the series, having already made his last physical appearance in the November 14, 2019 episode "My Shot", the 350th episode revolving around the trial for Meredith's medical license.
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What was Karev's last episode?

After being absent from the show for weeks, it was revealed in the March 5 episode that Karev had left Seattle and his new wife, Jo (Camilla Luddington), to reunite with his ex-wife, Izzie (the character played by long-departed cast member Katherine Heigl), and the former couple's children.
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Why did Karev leave GREY's so suddenly?

Justin Chambers' more recent comments go further than what he said back when the news broke that he was leaving after 15 years, as he stated in early 2020 that he wanted to “diversify” his acting roles and his career. His words about the "bubble" echo that sentiment about wanting more variety in his life.
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Are Justin Chambers and Ellen Pompeo friends?

Ellen Pompeo, 51, who plays Dr. Meredith Grey, began her weekend dining with former Grey's costars Eric Dane and Justin Chambers. On her Instagram Stories, which have since expired, Ellen shared clips of the three friends enjoying each other's company.
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Does Izzie return?

Izzie's time with cancer was rough, and it took a toll on her relationship with Alex. After she was fired from SGMW, she left Alex. Eventually, she did come back, wanting to reunite with Alex when she found out her cancer was gone.
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Grey's Anatomy: Alex Karev’s Final Episode Trailer Is Emotional AF



Why did Karev leave season 16?

Actor Justin Chambers left the show midway through season 16, so his character, Alex Karev, had to be given an off-screen exit. Using a mix of voiceover and letters, the showrunners had Alex leave Seattle to be with his ex-wife Izzie Stevens (Katherine Heigl).
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What episode does Alex leave in season 16?

After Meredith's medical license hearing in Grey's Anatomy Season 16, Alex went missing. He ghosted Jo, making her fear the worst. Then in the 16th episode titled “Leave a Light On,” Alex sent letters to Jo, Meredith, Richard Webber (James Pickens Jr.), and Miranda Bailey (Chandra Wilson).
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Where did Karev go in season 16?

Since the show's midseason return in late January, Grey's has been slowly offering up information about Karev's off-screen whereabouts. He was in Iowa “helping his mom” but still very much weighing in on hiring decisions at Pac-North and apparently sending hilarious texts to Richard Webber.
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Why did Alex leave Jo?

Alex explained that Izzie used their frozen embryos and gave birth to their twins. He also realized he was still in love with his ex. So Alex chose to leave Jo for a life with Izzie and their children in Kansas.
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Does Izzie return in Season 16?

Katherine Heigl finally weighed in on a shocking Grey's Anatomy twist that saw Alex Karev (Justin Chambers) and her character, Izzie Stevens, reunited in season 16.
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Does Alex come back in season 18?

Cormac Hayes), and Anthony Hill (Dr. Winston Ndugo) to return as series regulars, with Debbie Allen (Dr. Catherine Fox), Jason George (Dr. Ben Warren), Alex Landi (Dr.
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Does Izzie return in season 17?

Now, some viewers are hoping she will return after Patrick Dempsey (Derek Shepherd) and T.R. Knight (George O'Malley) reprised their roles in season 17. But, will Heigl come back to Grey's Anatomy in the future? Recently, the actor revealed the decision isn't up to her.
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Does Alex leave Jo for Izzie?

The news that Alex had left Jo (Camilla Luddington) for Izzie was a shock to fans everywhere. When it was announced that Justin Chambers would be leaving the series, not many fans seemed to have considered the ending the writers planned for Alex would be an ending that most would not like.
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Who does Jackson Avery end up with?

Jackson had five relationships with, in order, Lexie Grey (Chyler Leigh), Stephanie Edwards, April Kepner (Sarah Drew), Maggie Pierce, and Jo Wilson. He married Kepner and had two children: a son, Samuel, who died of osteogenesis imperfecta type II, and a daughter named Harriet.
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Who does Yang end up with?

Cristina Yang & Owen Hunt – After the shooting, Cristina and Owen decided to get married.
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Why do Jo and Alex get divorced?

In it, Alex explains that he is leaving Jo to be with his first wife, Izzie Stevens (Katherine Heigl), who secretly had his children. Alex emphasizes that if the choice was only between Jo and Izzie, he would pick his wife. Alex would pick Jo. But, there's more at stake than romantic destiny.
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Does Jo Wilson have a baby with Alex?

Following her estranged husband's death, she married Alex Karev until he left her for his ex-wife, Izzie. She is now the mother of Luna Ashton.
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Does Jo have a baby?

Jo adopted a baby in the 'Grey's Anatomy' season 17 finale

Amid the chaos of the pandemic at Grey Sloan in season 17, Jo met little baby Luna. The baby lost her mother due to complications, and Jo fell in love with the newborn while caring for her.
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Does Burke come back?

While mentioned in passing throughout later seasons, Burke officially returns in the tenth season in order to conclude Cristina Yang's departure from the series.
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Will GREY's Anatomy ever end?

Grey's Anatomy creator Shonda Rhimes and series star Ellen Pompeo have both said the long-running ABC medical drama will end when the actress decides to walk away.
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Who is leaving GREY's Anatomy 2021?

Richard Flood leaves 'Grey's Anatomy' after 3 seasons; Skylar Astin sets recurring role - ABC News.
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Is Alex coming back to GREY's Anatomy season 19?

The Grey's Anatomy Season 19 Plot

Since Astin likely won't return, there's also the possibility of a Jo and Link romance, especially now that the former admitted to being in love with her longtime friend.
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Will Cristina Yang come back in season 18?

While she is still canonically alive and makes pseudo-appearances in the form of onscreen text messages, season 17's finale confirmed Cristina Yang will never return. Alex's and Izzy's returns in season 18 are even less likely than Cristina's. Both characters abruptly left the series in seasons 16 and 6 (respectively).
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