What viral infections cause positive ANA?

In particular, several patients with a positive ANA test

ANA test

The estimated sensitivity and specificity of the ANA test for SLE were 100% and 86%, respectively. For other rheumatic diseases, sensitivity and specificity were 42% and 85%, respectively. The positive predictive value of the ANA test was 11% for SLE and 11% for other rheumatic diseases.

https://pubmed.ncbi.nlm.nih.gov › ...

Antinuclear antibody testing. A study of clinical utility - PubMed

result were found to have intracellular infections such as mycobacterial infections, syphilis, or scrub typhus. Keywords: Antinuclear antibodies; autoimmune diseases; infection; scrub typhus; tuberculosis.

Can infection cause a positive ANA test?

But having a positive result doesn't mean you have a disease. Many people with no disease have positive ANA tests — particularly women older than 65. Some infectious diseases and cancers have been associated with the development of antinuclear antibodies, as have certain drugs.

What infections cause false positive ANA?

Causes of a false-positive ANA include infection, malignancy, and certain medications. Therefore, a positive ANA test does not equal a diagnosis of lupus or any autoimmune or connective tissue disease.

Can inflammation cause a positive ANA test?

Autoantibodies to cartilage proteoglycan can be measured in several systemic and joint-specific rheumatic diseases including Sjogren's Syndrome, rheumatoid arthritis, lupus and ankylosing spondylitis [21], suggesting that undetected or preclinical joint inflammation may contribute to ANA positivity.

Can you have a positive ANA and not have an autoimmune disease?

A negative test for ANA may assist health care providers by decreasing the likelihood that a patient's symptoms are caused by an autoimmune disease. Some individuals, even those without a relative with autoimmune disease, may have a positive test for ANA and yet never develop any autoimmune disease.

Viral Infections: Causes, Diagnosis, Prevention, and Treatment | Merck Manual Consumer Version

Does fibromyalgia cause positive ANA?

False-positive ANA tests are particularly likely to occur in the elderly. Most of the false-positive ANAs were of low titer, but even a high-titer ANA is not proof of an underlying connective tissue disease. Therefore, not surprisingly, ANA testing is frequently positive in patients with fibromyalgia.

Can ANA change from negative to positive?

“A small percentage of people alternated between results,” Dr. Yeo acknowledged, with 9.4% of people going from a positive to a negative result; 10.5% moving from a negative to a positive result, and 1.9% going from positive to negative to positive.

What causes ANA titer to increase?

ANA titers can also increase with age among healthy people, so it's important to talk with a doctor about your symptoms and what your result means to you. If your primary doctor ordered the test, they may recommend a referral to a rheumatologist — an autoimmune disease specialist — to review any abnormal ANA results.

What cancers are associated with positive ANA?

Neoplastic diseases may cause positive ANA. Some authors have described that ANA is found in the sera from lung, breast, head and neck cancer patients as frequently as in RA and SLE 3, 4, 5. Chapman et al. 6 has suggested that in breast cancer they may be used as an aid to early diagnosis.

Can reactive arthritis cause positive ANA?

Some patients with rheumatoid arthritis (RA) as well as those with other collagen diseases are positive for antinuclear antibody (ANA).

How common are false positive ANA?

To detect ANA, medical professionals usually use the indirect immunofluorescence (IIF) assay on HEp-2 cells as the standard blood test (ANA-HEp-2). However, studies have revealed that a "false-positive" ANA test occurs in up to 13% of healthy individuals.

Can parasites cause positive ANA?

Elevated titers of Abs to annexin-V and prothrombin were the most prevalent in viral, parasitic, and rickettsial infections and to laminin in viral and parasitic infections. Elevated titers of ASCA and ANA were found in viral and bacterial infections. Antiphospholipid Abs were found in parasitic and Q-fever infections.

Can EBV cause positive ANA?

Acute EBV infection or reactivation is correlated with the presence of high ANA antibodies which gives way to the notion that the virus causes the dysregulation of the immune response towards self-antigens.

Does lymphoma cause positive ANA?

Conclusion: In conclusion, ANA and related autoantibodies can frequently be detected during lymphoma treatment. However, the majority of lymphoma patients with positive ANA did not display autoimmune diseases, demonstrating the lack of a strict correlation between the presence of ANA and autoimmune diseases.

What tests are done after a positive ANA?

For patients with a positive ANA, more tests are usually performed to check for other antibodies that can help confirm the diagnosis. This series of tests, commonly called an ANA panel, checks for the following antibodies: anti-double-stranded DNA, anti-Smith, anti-U1RNP, anti-Ro/SSA, and anti-La/SSB.

What is considered high ANA titer?

A titer of 1:160 or above is commonly considered a positive test result. Other conditions with ANA associations include Crohn's disease, mononucleosis, subacute bacterial endocarditis, tuberculosis, and lymphoproliferative diseases.

What causes positive ANA speckled pattern?

Speckled: Fine and coarse speckles of ANA staining are seen throughout the nucleus. This pattern is more commonly associated with antibodies to extractable nuclear antigens. This pattern can be associated with Systemic Lupus Erythematosus, Sjögren's syndrome, Systemic Sclerosis, Polymyositis, and Rheumatoid Arthritis.

What other diseases can mimic lupus?

What medications cause a positive ANA?

Can chronic fatigue syndrome cause a positive ANA?

Abstract. Autoimmune fatigue syndrome (AIFS) is defined by chronic nonspecific complaints, a positive antinuclear antibody (ANA) assay, and the absence of another explanation for the complaints. Some severe cases fulfill the criteria for chronic fatigue syndrome (CFS).

What are the top 10 signs of lupus?

What does an ANA titer of 1 160 mean?

Titers ≥ 1:160 usually indicate the presence of active SLE, although occasionally other autoimmune disease may induce these high titers. There are now known groups of ANA-negative lupus patients.

Can a virus trigger autoimmune disease?

Viruses have been considered as major environmental factors that trigger the autoimmune phenomena in genetically susceptible individuals [2,3]. Multiple mechanisms have been proposed to explain the breakdown of self-tolerance by viral infections (Figure 1).

What infections cause autoimmune diseases?

Which autoimmune disease is caused by the Epstein-Barr virus?

They found that a protein called Epstein-Barr virus nuclear antigen 2 (EBNA2) interacts with half the known genes that put a person at risk for lupus.