What organs does vitamin D3 affect?

Vitamin D undergoes further chemical changes, first in the liver and then in the kidneys, to become calcitriol

calcitriol

Calcitriol is the active form of vitamin D, normally made in the kidney. It is also known as 1,25-dihydroxycholecalciferol. It is a hormone which binds to and activates the vitamin D receptor in the nucleus of the cell, which then increases the expression of many genes.

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Calcitriol - Wikipedia

. Calcitriol acts on the intestine, kidneys, and bones to maintain normal levels of blood calcium and phosphorus.

What two organs can be affected by too much vitamin D?

The main consequence of vitamin D toxicity is a buildup of calcium in your blood (hypercalcemia), which can cause nausea and vomiting, weakness, and frequent urination. Vitamin D toxicity might progress to bone pain and kidney problems, such as the formation of calcium stones.

How does vitamin D3 affect the body?

Vitamin D3 is more efficient than D2. You get vitamin D from food, supplements, and sunshine. Vitamin D is important for bone and muscle strength and immune function. It may help prevent depression, inflammatory disease, and heart disorders.

Which organ is the first to metabolize vitamin D3?

Vitamin D₃ produced in the epidermis must be further metabolized to be active. The first step, 25-hydroxylation, takes place primarily in the liver, although other tissues have this enzymatic activity as well.

What depletes the body of vitamin D3?

Vitamin D deficiency is most commonly caused by a lack of exposure to sunlight. Some disorders can also cause the deficiency. The most common cause is lack of exposure to sunlight, usually when the diet is deficient in vitamin D, but certain disorders can also cause the deficiency.

How Vitamin D Affects Every Organ and Tissue

Who Cannot take vitamin D3?

Can D3 harm the liver?

[22] In these studies, Vitamin D supplement could not change any of the liver enzymes. In a study by Barchetta et al. [10] using Vitamin D3 (2000 IU/day) for a long duration (24 weeks) could not change the result of two previous studies.

What supplements are hard on the kidneys?

You should avoid some supplements if you have unhealthy kidneys, especially if you have chronic kidney disease. These supplements include vitamins A, D, E, and K because they can cause a buildup in your system.

Does vitamin D3 affect potassium levels?

Vitamin D3 tended to increase retention of both potassium and sodium in the body. A significant interaction occurred between dietary magnesium and vitamin D3 relative to body weight gain. Vitamin D3 increased magnesium content in tibiae ash and decreased magnesium content in serum.

What if I take vitamin D3 daily?

Taking too many vitamin D supplements over a long period of time can cause too much calcium to build up in the body (hypercalcaemia). This can weaken the bones and damage the kidneys and the heart. If you choose to take vitamin D supplements, 10 micrograms a day will be enough for most people.

How does taking vitamin D3 make you feel?

Vitamin D keeps your immune system strong and can help regulate insulin levels. It keeps your energy levels up and enhances your mood, too.

What are the dangers of vitamin D supplement?

What are the signs you need vitamin D?

What diseases are linked to low vitamin D?

What helps your kidneys get stronger?

Does vitamin d3 increase creatinine levels?

Vitamin D receptor activation has been associated with increased serum creatinine and reduced estimated glomerular filtration rates, raising concerns that its use may be detrimental to kidney function.

What can you take to strengthen your kidneys?

What vitamins are hard on your liver?

Avoid certain supplements: Excess iron, niacin, and vitamin A (the retinol form, not beta carotene) tend to stress an unhealthy liver.

What vitamins help repair fatty liver?

Exercise and healthy dietary supplements, including micronutrients, are promising methods to manage NAFLD. Vitamins A, B3, B12, D, and E can serve as targets for NAFLD therapy, although some are linked to adverse effects.

Can d3 cause heart problems?

Excess Vitamin D harms the heart - Study

Scientists have long known that low levels of the nutrient can hurt the heart, but new research shows that higher than normal levels can make it beat too fast and out of rhythm, a condition called atrial fibrillation.

Does D3 interfere with any medications?

Critical vitamin D3-drug interactions

Several commonly prescribed medications have a negative impact on vitamin D status. Medications most likely to affect the status or actions of vitamin D3 include those used to manage hyperlipidemia, arthritis, diabetes, depression, asthma, and COPD⁵.

What is the safest amount of vitamin D3 to take daily?

Unless your doctor recommends it, avoid taking more than 4,000 IU per day, which is considered the safe upper limit.