What is the most common treatment for syphilis?

Penicillin G, administered parenterally, is the preferred drug for treating patients in all stages of syphilis. The preparation used (i.e., benzathine, aqueous procaine, or aqueous crystalline), dosage, and length of treatment depend on the stage and clinical manifestations of the disease.
Takedown request   |   View complete answer on cdc.gov


What is the fastest treatment for syphilis?

Treating and curing syphilis

Primary and secondary syphilis are easy to treat with a penicillin injection. Penicillin is one of the most widely used antibiotics and is usually effective in treating syphilis. People who are allergic to penicillin will likely be treated with a different antibiotic, such as: doxycycline.
Takedown request   |   View complete answer on healthline.com


What antibiotics treat syphilis other than penicillin?

Doxycycline and tetracycline for 28 days have been used for many years and are the only acceptable alternatives to penicillin for the treatment of latent syphilis. Doxycycline is the preferred alternative to penicillin owing to its tolerability.
Takedown request   |   View complete answer on emedicine.medscape.com


Can syphilis be cured or just treated?

Yes, syphilis is curable with the right antibiotics from your healthcare provider. However, treatment might not undo any damage the infection can cause.
Takedown request   |   View complete answer on cdc.gov


What is the second line treatment for syphilis?

Background: Benzathine penicillin G is the treatment of choice for infectious syphilis, but tetracycline and doxycycline are believed to be effective second-line treatments.
Takedown request   |   View complete answer on pubmed.ncbi.nlm.nih.gov


Syphilis Treatment : All you need to know



What is the best antibiotic for syphilis?

When diagnosed and treated in its early stages, syphilis is easy to cure. The preferred treatment at all stages is penicillin, an antibiotic medication that can kill the organism that causes syphilis.
Takedown request   |   View complete answer on mayoclinic.org


How long should I take amoxicillin 500mg for syphilis?

UK guidelines for second-line drugs for treatment of men and non-pregnant women with late latent and tertiary syphilis include doxycycline (same as CDC guidelines) and amoxicillin (2 g orally, three times daily plus 500 mg probenecid orally, four times daily for 28 days) [ 12] (Table 1).
Takedown request   |   View complete answer on cambridge.org


What is one of the first signs of syphilis?

The first sign of syphilis is a small sore, called a chancre (SHANG-kur). The sore appears at the spot where the bacteria entered your body. While most people infected with syphilis develop only one chancre, some people develop several of them. The chancre usually develops about three weeks after exposure.
Takedown request   |   View complete answer on mayoclinic.org


Can Amoxicillin 500mg treat syphilis?

Amoxycillin is thus a safe and effective oral agent for the treatment of all stages of syphilis in man.
Takedown request   |   View complete answer on pubmed.ncbi.nlm.nih.gov


What is the strongest antibiotic for STD?

Single-dose therapy with azithromycin is as effective as a seven-day course of doxycycline (Vibramycin). Doxycycline is less expensive, but azithromycin may be cost-beneficial because it provides single-dose, directly observed therapy. Erythromycin and ofloxacin (Floxin) also may be used to treat C.
Takedown request   |   View complete answer on aafp.org


Can oral azithromycin treat syphilis?

Single-dose oral azithromycin is effective in treating syphilis and may be particularly useful in developing countries in which the use of penicillin G benzathine injections is problematic.
Takedown request   |   View complete answer on nejm.org


How long should I take doxycycline for syphilis?

However, multiple therapies might be effective for nonpregnant persons with penicillin allergy who have primary or secondary syphilis. Doxycycline (100 mg orally 2 times/day for 14 days) (600,601) and tetracycline (500 mg orally 4 times/day for 14 days) have been used for years and can be effective.
Takedown request   |   View complete answer on cdc.gov


Can azithromycin 500mg treat syphilis?

A large study finds that a single oral dose of azithromycin can be curative in patients with early syphilis. Even after all these years, a single dose of intramuscular penicillin G remains the preferred treatment for early-stage syphilis.
Takedown request   |   View complete answer on jwatch.org


How much penicillin do you take for syphilis?

Long-acting penicillin G benzathine (Bicillin® L-A) is the preferred antibiotic treatment for syphilis. Each dose requires two intramuscular injections, one injection into each hip or buttock muscle at the same visit. One dose of Bicillin® L-A 2.4 million units is usually adequate to treat early syphilis.
Takedown request   |   View complete answer on bccdc.ca


How long does it take for syphilis to go away with treatment?

You might not even notice the sore, because syphilis sores don't hurt. The sores go away after three to six weeks. If you don't treat syphilis early, it spreads from the sore into your blood.
Takedown request   |   View complete answer on aafp.org


How long does it take for azithromycin to cure syphilis?

In 90.3% of patients, the complete resolution of classic serological tests was observed within 4 months of completion of the azithromycin treatment.
Takedown request   |   View complete answer on pubmed.ncbi.nlm.nih.gov


How much amoxicillin do you take for syphilis?

Our findings indicate that treatment with 1.5 g/day of amoxicillin without probenecid is highly effective for the treatment of syphilis; comparable to the standard therapy.
Takedown request   |   View complete answer on sti.bmj.com


How much azithromycin should I take for syphilis?

A single, 2 g dose of oral azithromycin is just as effective as intramuscular penicillin G benzathine for the treatment of early syphilis, regardless of HIV status, researchers from the UK and Tanzania report (N Engl J Med 2005; 353: 1236–44).
Takedown request   |   View complete answer on thelancet.com


Is doxycycline good for treating syphilis?

As an alternative treatment, doxycycline presents several advantages. Our study showed excellent treatment outcomes in early syphilis patients (response rates, 100.0% in patients with primary syphilis, 96.9% in patients with secondary syphilis, and 91.3% in patients with early latent syphilis).
Takedown request   |   View complete answer on ncbi.nlm.nih.gov


What do syphilis sores look like?

The characteristic rash of secondary syphilis may appear as rough, red, or reddish brown spots both on the palms of the hands and the bottoms of the feet. However, rashes with a different appearance may occur on other parts of the body, sometimes resembling rashes caused by other diseases.
Takedown request   |   View complete answer on health.state.mn.us


What Can syphilis be mistaken for?

Primary Syphilis

Figure 3 shows examples of clinical lesions positive for syphilis using dark-field microscopy that could be mistaken for genital herpes or chancroid.
Takedown request   |   View complete answer on ncbi.nlm.nih.gov


Does syphilis cause a smell?

If symptoms do occur, they usually appear within four weeks of exposure. Symptoms in women include: Genital inflammation. Foul-smelling, yellow-green vaginal discharge.
Takedown request   |   View complete answer on verywellhealth.com


Can 1g of azithromycin cure syphilis?

Azithromycin therapy (1-g single dose) will result in fewer cases of early syphilis among exposed partners, provided that the drug's efficacy is at least 87%. Conclusions: Azithromycin is a cost-effective alternative treatment for incubating syphilis in settings where standard intramuscular therapy is not practical.
Takedown request   |   View complete answer on pubmed.ncbi.nlm.nih.gov


What antibiotics treat syphilis and gonorrhea?

The recommended treatment at all stages of this disease is the antibiotic penicillin. If you've been infected for less than a year, you may need just one injection of penicillin to be cured.
Takedown request   |   View complete answer on webmd.com


Can penicillin VK treat syphilis?

Penicillin VK is a prescription medicine used to treat the symptoms of serious infections, including strep throat and staph infections, diphtheria, meningitis, gonorrhea and syphilis. Penicillin VK may be used alone or with other medications.
Takedown request   |   View complete answer on rxlist.com