What is the most common cause of B12 deficiency?

Pernicious anaemia is the most common cause of vitamin B12 deficiency in the UK. Pernicious anaemia is an autoimmune condition that affects your stomach. An autoimmune condition means your immune system, the body's natural defence system that protects against illness and infection, attacks your body's healthy cells.

What is the root cause of B12 deficiency?

Atrophic gastritis is a major underlying cause of vitamin B12 deficiency, as is the prolonged use of proton pump inhibitors such as omeprazole, and H2-receptor blockers. One organism that is associated with vitamin B12 deficiency is Helicobacter pylori, found in over half of all patients.

What happens when your vitamin B12 is low?

Constipation, diarrhea, loss of appetite, or gas. Nerve problems like numbness or tingling, muscle weakness, and problems walking. Vision loss. Mental problems like depression, memory loss, or behavioral changes.

Is B12 deficiency serious?

If left untreated, the symptoms of vitamin B12 deficiency tend to worsen and irreversible problems involving the nerves and brain may develop. The risk of experiencing a number of serious complications, including heart failure, may also increase.

Who is most likely to have a B12 deficiency?

Causes of Vitamin B12 Deficiency | In-Depth Overview including Medications, Diseases

How long does it take to recover from vitamin B12 deficiency?

Once you begin treating your vitamin B12 deficiency, it can take up to six to 12 months to fully recover. It is also common to not experience any improvement during the first few months of treatment. If you can, it's a good idea to address what's causing the deficiency.

What autoimmune disease causes pernicious anemia?

Pernicious anemia is sometimes seen in association with certain autoimmune endocrine diseases, such as type 1 diabetes, hypoparathyroidism, Addison's disease, and Graves' disease.

Can low B12 cause aching legs?

Trouble walking. Over time, peripheral nerve damage resulting from vitamin B-12 deficiency can lead to movement problems. Numbness in the feet and limbs may make it hard for a person to walk without support. They may also experience muscle weakness and diminished reflexes.

Can low B12 cause joint pain?

It's necessary for maintaining both mental and physical health. Not getting enough vitamin B12 to the point of a deficiency can cause a variety of serious symptoms including depression, joint pain, and fatigue. Sometimes these effects can be debilitating to the point where you might think you're dying or seriously ill.

How can I raise my B12 levels fast?

What helps B12 absorption?

In the stomach, hydrochloric acid and enzymes unbind vitamin B12 into its free form. From there, vitamin B12 combines with a protein called intrinsic factor so that it can be absorbed further down in the small intestine. Supplements and fortified foods contain B12 in its free form, so they may be more easily absorbed.

Why does my body not absorb B12?

Since your body doesn't make vitamin B12, you have to get it from the foods you eat or from supplements. You can get vitamin B12 deficiency if you can't absorb vitamin B12 due to problems with your gut or if you have pernicious anemia, which makes it difficult to absorb vitamin B12 from your intestines.

Is vitamin D deficiency and B12 deficiency related?

Results: We found that vit-B12 deficiency and vit-D deficiency were associated with autoimmune hypothyroidism, and that there was a negative correlation between vit-B12 and vit-D levels and anti-TPO antibodies in these patients.

What medications should not be taken with B12?

Certain medications can decrease the absorption of vitamin B12, including: colchicine, metformin, extended-release potassium products, antibiotics (such as gentamicin, neomycin, tobramycin), anti-seizure medications (such as phenobarbital, phenytoin, primidone), medications to treat heartburn (such as H2 blockers ...

Does B12 deficiency cause back pain?

It is necessary for blood cell formation and repair, production of DNA and overall maintenance of brain cells. Vitamin B12 helps the body replace nerve cells in the spine and additionally also reduce inflammation, a common cause of chronic back pain.

Are there any side effects from B12 injections?

Commonly reported side effects of this type include, but are not limited to nausea, upset stomach, vomiting, mild diarrhea, and indigestion. These effects usually last a week after injections, but contact your doctor immediately if you are experiencing these symptoms in extreme fashion.

What does B12 neuropathy feel like?

The main neurological symptoms include: paraesthesia [8–12], ataxia [9–12], and limb weakness [9, 11]. The most prevalent psychiatric symptoms associated with B12 deficiency include, delusions [12, 13], irritability [13, 14], and decreased interest [15, 16].

Can vitamin B12 cause heart problems?

Macrocytosis associated with vitamin B12 deficiency is also associated with fatal and non-fatal coronary disease, myocardial infarction, stroke, and other circulatory health problems.

Why am I losing strength in my legs?

A feeling of sudden leg weakness, causing your legs to give out or buckle can be alarming. Weakness in your leg(s) may occur from problems in the nerves and/or muscles in your lower body and is usually treatable. Rarely, the underlying cause may be a serious medical condition requiring immediate medical attention.

What is the typical appearance of patients with pernicious anemia?

Typically, patients with pernicious anemia are described as having a stereotypic appearance: they have a lemon-yellow waxy pallor with premature whitening of the hair, and they appear flabby, with a bulky frame that is generally incongruent with the severe anemia and weakness.

What is the difference between pernicious anemia and B12 deficiency?

Pernicious anemia involves autoimmune inflammation in the stomach and the inability to absorb vitamin B12 in the small intestine. While vitamin B12 deficiency anemia may be caused by a lack of vitamin B12 in the diet, pernicious anemia is caused by an inability to absorb vitamin B12.

What is the fastest way to cure B12 deficiency?

Does stress deplete B12?

What is the relationship between vitamin B12 and stress? The fact is, high levels of stress can deplete your body of B vitamins, which are essential for the nervous and circulatory systems.