What is the most common age for females to be diagnosed with Paget's disease?

Paget's disease of the breast occurs most often after age 50. Most people with this diagnosis also have underlying ductal breast cancer, either in situ — meaning in its original place — or, less commonly, invasive breast cancer. Only rarely is Paget's disease of the breast confined to the nipple itself.

What age group is affected by Paget's disease?

Age. People older than 50 are most likely to develop the disease.

At what age is Paget's disease diagnosed?

Paget's disease is rarely diagnosed in people under the age of 40 years but may occur in up to three percent of the population over the age of 60 years. Paget's disease affects individuals of all ethnic and racial groups.

Can an 18 year old get Paget's disease?

It is extremely uncommon in young women. The presenting age ranges from 24 to 84 years with a mean age at diagnosis being 55 years [6]. This is one of the few reports in the literature of a woman presenting at a young age with Paget's disease of the breast, and this patient represents the third youngest such woman.

What is the youngest age to have Paget's disease of the breast?

Paget's disease of the breast most commonly affects middle-aged individuals, primarily occurring between 50 to 60 years of age, although it has been reported in individuals in their 20s.

Paget’s Disease of Bone (Osteitis Deformans) | Causes, Pathogenesis, Symptoms, Diagnosis

How rare is Pagets disease of the breast?

This means that there are cancer cells in the biopsy but they are completely contained within the lining of the breast ducts. Paget's disease is rare. It is found in around 1 to 4 out of every 100 breast cancers (around 1 to 4%). It can happen in men but this is even more rare.

How common is Pagets disease of breast?

Paget disease of the breast occurs in both women and men, but most cases occur in women. Approximately 1 to 4 percent of all cases of breast cancer also involve Paget disease of the breast. The average age at diagnosis is 57 years, but the disease has been found in adolescents and in people in their late 80s (2, 3).

How do you rule out Paget's disease?

An X-ray can show whether your bones have become enlarged as a result of Paget's disease of bone. Sometimes a bone scan called scintigraphy may also be carried out to check how much of your body is affected by the condition. For this scan, a small amount of a radioactive substance is injected into your blood.

Will a mammogram show Paget's disease?

Mammography. Mammography plays an important role in the diagnosis and management of Paget's disease; however, it has its own limitations and may be normal in some cases (Fig. 2).

Is it normal for a 13 year old to have a lump in her breast?

If you feel a lump in your breast, don't panic — breast cancer is extremely rare in teens. For teen girls, the most common type of breast lump is usually just part of normal breast growth. Lots of girls and women have something called fibrocystic breast changes.

What of the following is the most common appearance of Paget's disease?

Paget's disease can affect any bone in the skeleton. It appears most often in the spine, pelvis, long bones of the limbs, and skull. It can be present in just one bone or in several bones.

What is the life expectancy of someone with Paget's disease?

In that study, the British General Practice Research Database identified 2465 patients diagnosed with Paget's disease of bone from 1988 to 1999; retrospective review indicated that 5-yr survival was 67% in patients with Paget's disease compared with 72% in control patients.

Can Paget's disease be in both breasts?

Paget's disease can occur in both breasts, but this is quite rare. The disease generally affects only one breast. Paget's disease is a rare form of breast cancer and makes up only 1%-4% of all types of breast cancer. The disease usually starts at the nipple and extends to the areola.

How do you tell if you have Paget's disease?

How quickly does Paget's disease progress?

Mammary Paget's disease is associated with carcinoma of the underlying lactipherous ducts. The skin lesions progress slowly over months as scaly, fissured, or oozing erythema of the nipple and areola. Advanced lesions may appear as well-demarcated, eczema-like plaques with a pink or red hue.

Is Pagets disease fatal?

The disease may cause fractures, bowed legs, a curved spine or pinched nerves in the spine. Over time, enlarged or misshapen bones can stress nearby joints leading to osteoarthritis in those joints. In very rare cases, Paget's can turn into a life-threatening cancerous bone disease.

How can you tell the difference between Paget's disease and eczema?

Paget's disease may affect your nipple, while eczema rarely affects your nipple. Paget's disease also typically only affects one breast, while eczema affects both breasts and other parts of your chest. Paget's disease won't respond to the same treatments as eczema.

What kind of doctor do you see for Paget's disease of the breast?

As Paget's disease of the nipple is usually a sign of breast cancer, it's very important you see your GP if you notice changes to the tissue or skin of your breast. In particular, you should tell your GP if you notice any changes to: the skin of your nipple or areola (the darker area of skin around the nipple)

How can you prevent Paget's disease of the breast?

Is Pagets disease hereditary?

Inheritance. In 15 to 40 percent of all cases of classic Paget disease of bone, the disorder has an autosomal dominant pattern of inheritance. Autosomal dominant inheritance means that having one copy of an altered gene in each cell is sufficient to cause the disorder.

Which of the following diagnostic tests confirms Paget's disease?

Diagnosis of Paget's disease may be suspected based on the symptoms, but radiographs are the most specific diagnostic test. Asymptomatic patients with a first-degree relative with Paget's disease should be screened with a serum alkaline phosphatase test every two to three years.

Can you prevent Paget's disease?

Prevention. Paget's Disease is unavoidable for most people with the disorder, but exercise can help to maintain skeletal health, avoid weight gain to relieve pressure on the joints and bones, and maintain joint mobility.

Is Pagets an autoimmune disease?

Paget's disease of bone is a chronic autoimmune inflammatory disease that leads to an increase in bone reabsorption. While depression is extensively described in Paget's disease, affecting up to 50% of patients, the prevalence of manic episodes is unknown.

Which bones are commonly affected by Paget's disease?

Paget's disease of bone can affect 1 bone or several bones. Commonly affected areas include the pelvis, spine and skull.