What is the major concern for chronic Chagas disease patients?

If Chagas disease progresses to the long-lasting (chronic) phase, serious heart or digestive complications may occur. These may include: Heart failure. Heart failure occurs when your heart becomes so weak or stiff that it can't pump enough blood to meet your body's needs.

What is chronic Chagas disease?

Chagas disease, also known as American trypanosomiasis, is a potentially life-threatening illness caused by the protozoan parasite Trypanosoma cruzi. About 6–7 million people worldwide are estimated to be infected with T. cruzi.

What are the risk factors of Chagas disease?

Chagas disease is a disease caused by the parasite Trypanosoma cruzi. You're most at risk for Chagas disease if you have visited or traveled in rural Central or South America or been exposed to the blood products, or received organs, from someone infected with Chagas disease.

How does Chagas disease affect the body?

Symptoms of Chagas disease in the acute phase (the first few weeks or months) are: Mild, flu-like symptoms, such as fever, fatigue, body aches, and headaches. Rash. Loss of appetite.

Should patients with chronic Chagas disease be treated with Antitrypanosomal drugs?

Summary. Treatment with antitrypanosomal drugs can cure CD in acute, congenital, and early chronic cases and provides improved clinical outcomes for chronic indeterminate cases. This treatment should be offered as early as possible, before advanced CCM develops.

Chagas Disease | American Trypanosomiasis | Causes, Symptoms and Treatment

How is chronic Chagas treated?

Treatment for Chagas disease focuses on killing the parasite and managing signs and symptoms. During the acute phase of Chagas disease, the prescription medications benznidazole and nifurtimox (Lampit) may be of benefit. Both drugs are available in the regions most affected by Chagas disease.

Why does Chagas disease cause heart failure?

The pathology of Chagas disease is based in an inmunoinflammatory reaction producing fibrosis and remodelling, mainly in the myocardium. In many cases these mechanisms result in a dilated cardiomyopathy with HF and reduced ejection fraction, frequent cardiac arrhythmias and different types of heart block.

Does Chagas affect the brain?

The involvement of the central nervous system (CNS) during human acute and chronic Chagas disease (CD) has been largely reported. Meningoencephalitis is a frequent finding during the acute infection, while during chronic phase the CNS involvement is often accompanied by behavioral and cognitive impairments.

Can Chagas cause death?

Chagas disease causes approximately 10,000 deaths per year globally. Up to 30% of infected people develop symptoms. Chagas disease can cause: Stroke.

How do you test for chronic Chagas?

The diagnosis of Chagas disease can be made by observation of the parasite in a blood smear by microscopic examination. A thick and thin blood smear are made and stained for visualization of parasites.

What is the difference between acute and chronic Chagas disease?

The natural history of Chagas disease is divided into two phases, acute and chronic. The acute phase lasts approximately 8 weeks, and usually causes mild or no symptoms. Patients with chronic Chagas disease have lifelong infection in absence of treatment. Spontaneous cure is extremely rare.

What are the neurological symptoms of Chagas disease?

In the chronic phase, it presents as neuritis that results in altered tendon reflexes and sensory impairment, and is reported in up to 10% of the patients. Isolated cases of central nervous system involvement can also include dementia, confusion, chronic encephalopathy and sensitive and motor deficits.

Can you live with Chagas disease?

Many people may remain asymptomatic for life and never develop Chagas-related symptoms. However, an estimated 20–30% of infected people will develop severe and sometimes life-threatening medical problems over the course of their lives.

Does Chagas affect the liver?

Trypanosoma cruzi, the etiological agent of Chagas' disease, causes an intense inflammatory response in several tissues, including the liver. Since this organ is central to metabolism, its infection may be reflected in the outcome of the disease.

Does Chagas need to be treated?

Treatment for Chagas disease is recommended for people diagnosed early in the course of infection (acute phase), babies with congenital infection, and for those with suppressed immune systems. Many patients with chronic infection may also benefit from treatment.

Can you donate blood if you have Chagas disease?

If you have ever been diagnosed with Chagas disease, you cannot donate blood.

What is the prognosis for Chagas?

Chagas disease can cause both sudden (acute) and long-term (chronic) symptoms. People can be infected for a long time without showing symptoms. Without treatment, serious complications, including heart and intestinal tract problems, are possible. Chagas disease is curable if treated soon after infection.

Should I be worried about Chagas disease?

Chagas disease (T. cruzi infection) is also referred to as American trypanosomiasis. It is estimated that as many as 8 million people in Mexico, Central America, and South America have Chagas disease, most of whom do not know they are infected. If untreated, infection is lifelong and can be life threatening.

What type of drug would you use to treat Chagas?

The two drugs used to treat infection with T. cruzi are nifurtimox and benznidazole. Benznidazole is approved by FDA for use in children 2–12 years of age and is available from www.benznidazoletablets.com .

Is Chagas disease autoimmune?

In fact, the first evidence of autoimmunity in CD was presented by Cossio and collaborators in 1974 (61), who reported antibodies in sera of chagasic patients that reacted with endocardium, interstitium, and heart blood vessels but were absent in healthy individuals and in patients with non-chagasic cardiomyopathy.

Is Chagas disease an STD?

Conclusions: Evidence that Chagas disease can be transmitted sexually, coupled with the migration of individuals with Chagas disease to previously non-endemic countries and increased travel to endemic countries, has implications for public health.

Can Chagas spread from person to person?

Chagas disease can be transmitted in five different ways: by a vector (through the faeces of an insect), through vertical or congenital transmission (from mother to her child during pregnancy), by way of blood transfusions or organ transplants, by ingesting contaminated food or drinks, or because of laboratory ...

How do you protect yourself from Chagas?

Does Chagas disease cause weight loss?

GI symptoms, such as dysphagia, odynophagia, weight loss, prolonged constipation.

What is the drug of choice for Chagas disease?

* Benznidazole is FDA-approved for the treatment of Chagas disease (American trypanosomiasis) caused by Trypanosoma cruzi in pediatric patients 2–12 years of age.