What is the life expectancy of someone with Paget's disease?

In that study, the British General Practice Research Database identified 2465 patients diagnosed with Paget's disease of bone from 1988 to 1999; retrospective review indicated that 5-yr survival was 67% in patients with Paget's disease compared with 72% in control patients.

Is Paget's disease life threatening?

In very rare cases, Paget's can turn into a life-threatening cancerous bone disease. Severe Paget's disease may cause damage to the heart.

What are the stages of Paget disease?

Three phases of Paget disease have been described: lytic, mixed lytic and blastic, and sclerotic. In an individual patient, different skeletal lesions may progress at different rates. Thus, at any one time, multiple stages of the disease may be demonstrated in different skeletal regions.

What is one of the most serious complications of Paget disease?

If Paget's disease of bone affects the skull, there's a significant risk that it could lead to permanent hearing loss and possibly total deafness. This can occur as a result of damage to the bones or nerves that connect the ears to the brain.

Does Paget's disease affect the brain?

Paget's disease of bone is associated with involvement of the central and peripheral nervous system. The brain, spinal cord, cauda equina, spinal roots, and cranial nerves can be affected in Paget's disease due to their anatomic relationship to bone.

PAGET'S DISEASE OF BONE - FAST REVIEW - DEFINITION, CAUSE, STAGES, INVESTIGATIONS, MANAGEMENT

How quickly does Paget's disease progress?

Mammary Paget's disease is associated with carcinoma of the underlying lactipherous ducts. The skin lesions progress slowly over months as scaly, fissured, or oozing erythema of the nipple and areola. Advanced lesions may appear as well-demarcated, eczema-like plaques with a pink or red hue.

Does Paget's disease cause fatigue?

When Paget's disease is active in several bones, overactive osteoclasts may release enough calcium from the bone as they break it down to cause an elevated calcium level in the blood. This rare complication can lead to a number of symptoms, including: Fatigue. Weakness.

Is Paget's disease curable?

There's currently no cure for Paget's disease of bone, but treatment can help relieve the symptoms. If you do not have any symptoms, your doctor may suggest keeping an eye on your condition and delaying treatment until any problems occur.

How does Paget's disease affect the body?

Overview. Paget's (PAJ-its) disease of bone interferes with your body's normal recycling process, in which new bone tissue gradually replaces old bone tissue. Over time, bones can become fragile and misshapen. The pelvis, skull, spine and legs are most commonly affected.

Can Paget's disease cause memory loss?

Hydrocephalus and dementia in Paget's disease of the skull☆

The memory loss of the early stages was followed later by progressive psychomotor retardation, apathy and inattention eventually leading to stupor and akinetic mute states.

Is Paget's bone disease a disability?

Many patients with Paget's disease are symptom-free, or when symptoms are present, they resemble those of many other diseases. However, pain and symptoms can be severe in some patients. The disease can lead to major deformities of the skeleton and is an important cause of permanent disability.

What are the four most common areas affected by Paget's disease?

The new bone may occur in one or more regions of the body and is structurally abnormal, dense and fragile. This abnormal development may cause bone pain, arthritis, deformities and fractures. The bones most frequently affected are in the spine, skull, pelvis and lower legs.

Do you need chemo for Paget's disease?

After your operation, your doctor may recommend additional treatment (adjuvant therapy) with anti-cancer drugs (chemotherapy), radiation therapy or hormone therapy to prevent a recurrence of breast cancer.

Is Paget's disease benign or malignant?

Paget's disease of the breast is a malignant (cancerous) condition that initially appears as chronic, inflammatory, “eczema-like” changes of the nipple and adjacent areas.

What is the best treatment for Paget's disease?

Osteoporosis drugs (bisphosphonates) are the most common treatment for Paget's disease of bone. Bisphosphonates are typically given by injection into a vein, but they can also be taken by mouth. When taken orally, bisphosphonates are generally well tolerated but can irritate the stomach.

How do you get rid of Paget's disease?

Paget disease can be treated by removing the entire breast (mastectomy) or breast-conserving surgery (BCS) followed by whole-breast radiation therapy. If BCS is done, the entire nipple and areola area also needs to be removed. If invasive cancer is found, the lymph nodes under the arm will be checked for cancer.

Are there any new treatments for Paget's disease?

There is widespread agreement that a single intravenous injection (5 mg) of zoledronate (also known as zoledronic acid) is the first-line therapy for Paget's disease ^{18, 19}.

Is Pagets an autoimmune disease?

Paget's disease of bone is a chronic autoimmune inflammatory disease that leads to an increase in bone reabsorption. While depression is extensively described in Paget's disease, affecting up to 50% of patients, the prevalence of manic episodes is unknown.

What is the most common age for females to be diagnosed with Paget's disease?

Paget's disease of the breast occurs most often after age 50. Most people with this diagnosis also have underlying ductal breast cancer, either in situ — meaning in its original place — or, less commonly, invasive breast cancer. Only rarely is Paget's disease of the breast confined to the nipple itself.

Where does Paget's disease start?

Symptoms of Paget's disease of the nipple

Paget's disease of the nipple always starts in the nipple and may extend to the areola. It appears as a red, scaly rash on the skin of the nipple and areola. The affected skin is often sore and inflamed, and it can be itchy or cause a burning sensation.

Do symptoms of Pagets disease come and go?

In most cases, Paget's disease affects one breast, and the symptoms may come and go. This means symptoms may cycle through, appearing to improve and then worsen again. The symptoms may look similar to eczema or other such skin conditions.

Does Pagets disease affect your teeth?

Paget's disease is an uncommon disorder that leads to abnormal bone development. Your jawbones will be affected, and this can cause mild or severe dental health issues such as tooth loss, jaw fractures, and bite alignment. Furthermore, there are times when jawbone deformities might occur.

Can Paget's cause dizziness?

Neurologic manifestations of Paget's disease before the radiographic appearance of the bone changes is an uncommon presentation of the disorder[3]. Early neurological symptoms include headache[4], dizziness, deafness, tinnitus and pain due to radicular compression[3].

What specialist treats Pagets?

Paget's disease can affect many parts of the body. You may need to see more than one type of doctor, including: Endocrinologists, who treat hormonal and metabolic disorders. Rheumatologists, who treat joint and muscle disorders.