What is the difference between CIN 2 and CIN3?

CIN2 – indicates moderate changes; affecting two-thirds of the thickness of the surface layer of the cervix. CIN3 – indicates more severe changes (not cancer); affecting the full thickness of the surface layer of the cervix. Even with CIN2 or CIN3 grade changes, the cell changes are unlikely to be cancer.

Is CIN 2 and CIN 3 a cancer?

Abnormal cells are found on the surface of the cervix. CIN 2/3 is usually caused by certain types of human papillomavirus (HPV) and is found when a cervical biopsy is done. CIN 2/3 has features of CIN 2 and CIN 3. It is not cancer, but may become cancer and spread to nearby normal tissue if not treated.

Can CIN 2 turn into CIN3?

CIN 1 lesions generally clear up on their own. CIN 2 lesions often clear up on their own, but can also progress to CIN 3 lesions. CIN 3 is the most severe. It's a very slow-growing disease, though: fewer than half of CIN 3 lesions will have become cancer within 30 years.

What are the chances of CIN 2 turning into cancer?

Approximately 60% of CIN 1 lesions regress without treatment and less than 1% progress to cancer. However, it is estimated that 5% of CIN 2 and 12% of CIN 3 cases will progress to invasive cancer if untreated.

How long does it take for CIN 2 to progress to CIN3?

In a meta-analysis of 36 studies (both randomized trials and observational studies) including 3160 patients with CIN 2, at 24 months, lesions regressed in 50 percent of patients, persisted in 32 percent, and progressed to CIN 3+ in 18 percent [14].

What is CIN

Should I be worried about CIN 2?

CIN 2 means two-thirds of the thickness of the cervical surface layer is affected by abnormal cells. There is a higher risk the abnormal cells will develop into cervical cancer. You may be offered treatment to stop this happening, or another colposcopy.

Can CIN3 come back after LEEP?

Definitely. A few women we spoke interviewed did have a recurrence of abnormal cells after treatment for CIN3, and this was often found at a follow-up appointment. Most were treated again by LLETZ.

How long does it take for CIN 2 to regress?

Conclusion: CIN2 lesions regress without treatment in one year, although an ablative procedure is more effective.

Does CIN 2 mean I have HPV?

CIN 2 is usually caused by certain types of human papillomavirus (HPV) and is found when a cervical biopsy is done. CIN 2 is not cancer, but may become cancer and spread to nearby normal tissue if not treated.

How quickly can CIN3 develop?

It has been estimated that the mean calculated time from infection to diagnosis of CIN3+ is 9.4 years (SD 4.1 years) and progression from CIN3 to invasive cervical cancer takes 10–20 years, depending on genotype [7, 8].

Is CGIN worse than CIN?

CGIN is usually classified as low grade (mild) or high grade (severe). High grade CGIN is the equivalent of CIN3. CGIN can be multi-focal – this means that more than one area is affected at one time, with normal tissue lying between them.

What stage is CIN 2?

Cervical intraepithelial neoplasia (CIN) is classified on a scale from one to three. CIN 1: Refers to abnormal cells affecting about one-third of the thickness of the epithelium. CIN 2: Refers to abnormal cells affecting about one-third to two-thirds of the epithelium.

Will a hysterectomy cure CIN3?

A hysterectomy will not cure the HPV which has caused the CIN, as there is no cure for HPV, but the CIN cannot have spread anywhere else in your body and will only be in your cervix area-it doesn't travel through the bloodstream, and remains where the HPV infection is.

How common is CIN3?

1554 women (1.9%) developed recurrent CIN3 and 397 women (0.5%) cervical cancer.

How long before precancerous cells turn cancerous?

These aren't cancer cells, but cells that may turn cancerous if left untreated for many years. It takes 10-15 years for pre-cancer to progress to cancer. If you already have cancer cells, this would show up as malignancy.

What is the best treatment for CIN 2?

laser or loop electrosurgical excision procedure (leeP) are the preferred treatment methods for recurrent CIN 2 and CIN 3 (sor: B, based on clinical trials without randomization).

What type of HPV causes CIN 2?

Results: HPV was detected in 92.9% of women with CIN 2-3 and high-risk HPV (HR-HPV) was detected in 85.8% of them. In women with cervical cancer, HPV was positive in 96.5%, HR-HPV detected in 93%.

What does CIN 3 stand for?

CIN 3 is sometimes called high-grade or severe dysplasia. Also called cervical squamous intraepithelial neoplasia 3.

What happens if CIN 2 is left untreated?

High-Grade Abnormalities CIN-2 & CIN-3

These cells are more likely to become cancerous and invade deeper layers of the cervix if left untreated. If high-grade abnormalities are detected on a Pap smear, the woman is advised to have a colposcopy and biopsy.

Do you still have HPV after LEEP procedure?

Although LEEP does not completely eradicate HPV infection, our results indicate that most HR-HPV infections are cleared after LEEP with negative margins. The clearance rate is increasing gradually after surgery. Our persistence rate was 40.9 % at 6 months, 20 % at 12 months and 11.8 % at 18 months.

Should I get a hysterectomy if I have precancerous cells?

If the precancerous disease is more extensive or involves adenocarcinoma in situ (AIS), and the woman has completed childbearing, a total hysterectomy may be recommended. 1 During a total hysterectomy, the entire uterus (including the cervix) is removed.

How many times can LEEP be performed?

If the margins are positive, you may need a repeat procedure. In addition, six months following a LEEP, you'll have a follow-up appointment that includes Pap and HPV tests. In some cases, abnormal cells are found again. If this happens, you may require another LEEP.

What is the next step after a LEEP procedure?

The most common next step after a LEEP procedure is to get a pap smear in six months. It is Really Important to get a follow-up pap smear, after the LEEP procedure.

Does CIN 2 always need treatment?

Right now, CIN2 is typically treated. But some studies have suggested that CIN2 lesions often regress completely without treatment and should therefore be simply monitored instead.

How serious are precancerous cells?

Often, precancerous lesions are not invasive and a person will not develop cancer. In some cases these precancerous cells, if left alone, may go on to become “invasive” cancer cells. Sometimes, it may take these cells a few years, or even decades to progress.