What is the cost of XIAFLEX injections?

Xiaflex costs $3,300 an injection, so a full course of eight injections would cost about $26,000, in addition to a doctor's fee. Doctors already use less expensive drugs off-label to treat Peyronies, including injections of a generic blood pressure drug.

What is the success rate of Xiaflex?

Success rates vary but studies demonstrate an average 34% improvement in the curvature (or 17-degree decrease from baseline curvature). 60% of men getting Xiaflex experienced improvement compared to 30% with placebo.

Are Xiaflex injections covered by insurance?

This is considered a cosmetic use and therefore not covered under the medical benefit.

How many Xiaflex injections do I need?

No more than 3 injections, each 4 weeks apart, should be given in the same area. If you are using this medication to treat Peyronie's disease, the medication is injected into the plaque in the penis by your healthcare provider.

How much is the injection for Peyronie's disease?

In 2013, CCH injections became the first FDA-approved drug treatment for Peyronie's, indicated for men with palpable plaque and curvature of at least 30 degrees. The treatment costs around $4,000 per injection, with a standard therapeutic course involving eight total injections.

Collagenase injections (Xiaflex) for Peyronie's disease | UroChannel

What vitamins help with Peyronie's disease?

While Peyronie's disease is most often found in middle-aged men, it can occur at any age. Drug therapy is helpful for most men who are affected by Peyronie's disease, especially during the acute phase. For instance, oral Vitamin E will make the plaques smaller and help to straighten the bent penis.

Can I fix Peyronie's disease myself?

Peyronie disease often happens in a mild form that heals on its own in 6 to 15 months. There is no cure for Peyronie disease.

How painful are XIAFLEX injections?

Pain. Although Xiaflex is not uncomfortable to receive, some patients have significant pain for up to 48 hours after the injection, with rare patients having discomfort beyond this period. Verapamil is more painful to receive, likely due to the volume of fluid, but is not significantly painful thereafter.

Why was XIAFLEX discontinued?

The decision to withdraw is not based on safety or efficacy concerns. Despite best efforts to appropriately educate the government and the market on XIAFLEX® over the past several years, the product did not receive government reimbursement approval and demand for the product has remained unsustainably low.

How do I pay my XIAFLEX injection?

Bill as 2 units OR 2 separate lines of 1 unit

If you have questions about XIAFLEX ^® coding, please contact Endo Advantage^™ at 1-877-XIAFLEX (1-877-942-3539) or the payor's Provider Service Representative. Application of finger splint should be used only when the procedure is performed in a physician's office.

How long does it take for XIAFLEX to work?

Treatment cycles are typically spaced about 4-6 weeks apart. Some men may see improvements after one or two cycles, while men with severe curvatures may benefit more from three or four cycles.

Is there a generic for XIAFLEX?

Xiaflex is available in a generic form as collagenase Clostridium histolyticum.

Is there a pill to cure Peyronie's disease?

The U.S. Food and Drug Administration today approved a new use for Xiaflex (collagenase clostridium histolyticum) as the first FDA-approved medicine to treat men with bothersome curvature of the penis, a condition known as Peyronie's disease.

How often is XIAFLEX given?

Xiaflex is usually given in a treatment cycle of 1 to 3 injections given 4 weeks apart. After your injection, do not touch or put pressure on the treated area of the hand for the rest of the day. Keep the treated hand elevated until bedtime.

Does XIAFLEX help erectile dysfunction?

Damage to the penis may not get better after penile fracture, even with surgery. This could lead to permanent inability to have an erection. Studies have shown 34% improvement in penile curvature in men who underwent treatment with Xiaflex injection compared to 18% improvement in men treated with saline injection.

Is there an alternative to xiapex?

Unfortunately, Xiapex has been withdrawn from clinical use for Dupuytren's disease for commercial reasons. This is very disappointing as it was proving to highly effective. Mike is able to offer alternatives including percutaneous needles fasciotomy (PNF) or open surgery.

Why was xiapex withdrawn?

The withdrawal was at the request of the marketing authorisation holder, Swedish Orphan Biovitrum AB (publ), which notified the European Commission of its decision to permanently discontinue the marketing of the product for commercial reasons.

How long is XIAFLEX treatment?

Treatment with Xiaflex® is a 3-day process that includes the injection of the solution, finger extension, and fabrication of a night-time splint.

Does XIAFLEX decrease size?

Xiaflex treatment for Peyronie's disease may improve penile curvature degree with no effect on the loss on penile length in post-marketing analysis. Paper presented at 2021 Sexual Medicine Society of North America Annual Meeting; October 21-24, 2021.

What is the newest treatment for Peyronie's disease?

Xiaflex (collagenase clostridium histolyticum) is an FDA approved prescription medicine that is administered by a trained professional only. Xiaflex is injected directly into the hardened tissue in two courses, and the area is massaged to successfully break down the scar tissue.

Can Viagra help Peyronie's disease?

There is currently no evidence to support the use of Viagra or any other oral pills or supplements for the management of Peyronie's disease. Viagra has not been shown to improve the curvature or the deformity that is associated with Peyronie's disease.

How do you break up Peyronie's scar tissue?

Your doctor might suggest injecting a drug into the penis to break up the scar tissue. Some doctors use a drug called verapamil. Studies show it can decrease the curve and pain in many men. Collagenase clostridium histolyticum (Xiaflex) is another injected drug for treating Peyronie's.

How do you dissolve Peyronie's plaque?

Intralesional collagenase injections (Xiaflex) are currently the only FDA-approved treatment for Peyronie's disease. Collagenase is an enzyme that helps break down the substances that make up plaques. Breaking down the plaques reduces penile curving and improves erectile function.

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