What is Landau Kleffner syndrome?

Definition. Landau-Kleffner syndrome (LKS) is a rare, childhood neurological disorder characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electro-encephalogram (EEG).

Is Landau Kleffner syndrome curable?

Can Landau-Kleffner syndrome be cured? Some children regain their ability to speak and understand language. Others may partly recover their language skills. Children who start showing symptoms after age 6 and begin speech therapy right away have the best chance of improving.

What are some symptoms of Landau Kleffner syndrome?

Landau-Kleffner syndrome (LKS) is a condition that shows up during childhood, causing difficulties with speech and seizures. Children with LKS lose the ability to talk and understand speech. This loss is called aphasia. Many children with LKS also have seizures, episodes of uncontrolled body movement.

How do you treat Landau Kleffner syndrome?

In rare cases, surgery may be done. Medications often used are steroids or a high dose diazepam at night. Other medications that have been used to treat this epilepsy syndrome include clobazam (Onfi), ethosuximide (Zarontin), valproic acid (Depakote/Depakene), acetazolamide (Diamox) and levetiracetam (Keppra).

Is Landau Kleffner syndrome hereditary?

Gene changes may be passed from a parent to a child. A child of someone with LKS has a high risk of inheriting a gene change that causes LKS. But not all people with LKS may have gene changes that have been passed down. And a gene passed from parent to child may not cause disease symptoms.

Landau-Kleffner syndrome - Medical Meaning and Pronunciation

What are the 3 main symptoms of Aspergers?

How many people have LKS?

It occurs in approximately one child in a million. The disease is more common in boys and does not usually run in families. LKS may also be referred to as: Acquired aphasia* of childhood with seizures.

Who discovered Landau Kleffner?

It is named after William Landau and Frank Kleffner, who characterized it in 1957 with a diagnosis of six children.

Is LKS curable?

The prognosis for children with LKS varies. Some affected children may have a permanent severe language disorder, while others may regain much of their language abilities (although it may take months or years). In some cases, remission and relapse may occur.

Can Eses be cured?

These results indicate that steroids and surgery are the most effective treatments for ESES/CSWS. Normal development prior to onset of ESES and shorter treatment lag were associated with better outcomes. Patients without a structural lesion fared better than those with a lesion (except for those treated surgically).

Can seizures cause regression?

Regression in children with epilepsy may involve loss of cognitive abilities, failure to progress or a slowing of developmental trajectory. A few seizures do not lead to regression. Large numbers of seizures may be associated with regression but the cause is an important cofounder.

What is Rasmussen disease?

Rasmussen's encephalitis (RE) is a very rare, chronic inflammatory neurological disease that usually affects only one hemisphere (half) of the brain. It most often occurs in children under the age of 10 but can also affect adolescents and adults.

How do you pronounce Landau Kleffner?

Landau-Kleffner Syndrome Pronunciation. Lan·dau-Kl·effn·er Syn·drome.

What are reflex seizures?

Reflex epilepsies are a group of epilepsy syndromes in which a certain trigger or stimulus brings on seizures. The trigger can be something simple in the environment or something more complex. Simple environmental triggers include sensations like touch, light or movement.

What is a frontal lobe seizure?

Frontal lobe seizures are a common form of epilepsy, a neurological disorder in which clusters of brain cells send abnormal signals and cause seizures. These types of seizures stem from the front of the brain.

What causes temporal lobe epilepsy?

Temporal lobe epilepsy may be caused by an injury to the brain, such as a traumatic injury or infection. There are many other causes such as brain tumors, vascular malformations, and developmental abnormalities.

Can seizures cause speech delay in toddlers?

The seizures, which usually occur during sleep, cause twitching, numbness, or tingling of the face or tongue, often causing drooling and impairing speech.

Can seizures cause aphasia?

Ictal or postictal aphasia, also known as epileptic aphasia, occurs following epileptic seizures and is a common event (3).

What is the difference between a partial seizure and a generalized seizure?

Generalized seizures are produced by electrical impulses from throughout the entire brain, whereas partial seizures are produced (at least initially) by electrical impulses in a relatively small part of the brain. The part of the brain generating the seizures is sometimes called the focus.

What is LKS test?

LKS is diagnosed when a doctor sees clinical features that are consistent with the syndrome such as a loss of speech and an electroencephalogram (EEG) that shows specific kinds of seizure activity. Genetic testing can be used to confirm if there is a genetic change in GRIN2A, but this testing is not done routinely.

What is Panayiotopoulos syndrome?

Panayiotopoulos syndrome can be best defined as idiopathic susceptibility to early onset benign childhood seizures with electroencephalograhic occipital or extra occipital spikes, and manifests mainly with autonomic seizures.

What is the most distinctive symptom of a person with Asperger's?

One telltale sign of Asperger's syndrome is having difficulty in social situations. Common symptoms of Asperger's that may impact social interaction or communication include: Problems making or maintaining friendships. Isolation or minimal interaction in social situations.

Can you tell if someone has Asperger's?

Symptoms of Asperger's, or “autism spectrum disorder,” include rarely changing facial expression, not making eye contact when speaking to others, talking incessantly about a single topic and not noticing that others are not listening, standing too close to others, inability to determine when another person is joking, ...

How do adults with Aspergers behave?

Adults who experience Asperger's may find it challenging to deal with their emotional responses to situations or events. This can cause the person to react inappropriately or have emotional outbursts. People may also have difficulty understanding the emotional experiences of others.