What is CIN 2 colposcopy?

CIN 2. CIN 2 means two-thirds of the thickness of the cervical surface layer is affected by abnormal cells. There is a higher risk the abnormal cells will develop into cervical cancer. You may be offered treatment to stop this happening, or another colposcopy.

What does it mean if I have CIN 2?

Moderately abnormal cells are found on the surface of the cervix. CIN 2 is usually caused by certain types of human papillomavirus (HPV) and is found when a cervical biopsy is done. CIN 2 is not cancer, but may become cancer and spread to nearby normal tissue if not treated.

Should CIN 2 be treated?

Right now, CIN2 is typically treated. But some studies have suggested that CIN2 lesions often regress completely without treatment and should therefore be simply monitored instead.

What are the chances of CIN 2 turning into cancer?

Approximately 60% of CIN 1 lesions regress without treatment and less than 1% progress to cancer. However, it is estimated that 5% of CIN 2 and 12% of CIN 3 cases will progress to invasive cancer if untreated.

Will CIN 2 Go Away?

CIN 2 lesions often clear up on their own, but can also progress to CIN 3 lesions. CIN 3 is the most severe. It's a very slow-growing disease, though: fewer than half of CIN 3 lesions will have become cancer within 30 years.

COLPOSCOPY - Endocervical HSIL CIN II

What type of HPV causes CIN 2?

Results: HPV was detected in 92.9% of women with CIN 2-3 and high-risk HPV (HR-HPV) was detected in 85.8% of them. In women with cervical cancer, HPV was positive in 96.5%, HR-HPV detected in 93%.

How long does it take for CIN 2 to go away?

In a meta-analysis of 36 studies (both randomized trials and observational studies) including 3160 patients with CIN 2, at 24 months, lesions regressed in 50 percent of patients, persisted in 32 percent, and progressed to CIN 3+ in 18 percent [14].

How long does it take for CIN 2 to regress?

Conclusion: CIN2 lesions regress without treatment in one year, although an ablative procedure is more effective.

Does CIN 2 come back?

Women treated for CIN2 or CIN3 retain an elevated risk of recurrence or even invasive cancer for years following treatment (2, 3). Thus, heightened surveillance has been the rule, with uncertainty as to whether (and when) a return to normal screening intervals can be safely permitted.

Does removing the cervix get rid of HPV?

Surgically treating genital warts doesn't cure a human papillomavirus (HPV) infection, however, and warts can return after surgery if the immune system does not eliminate the infection. Surgery may be used to treat moderate to severe cervical dysplasia by removing abnormal cells on the cervix.

What is the best treatment for CIN 2?

laser or loop electrosurgical excision procedure (leeP) are the preferred treatment methods for recurrent CIN 2 and CIN 3 (sor: B, based on clinical trials without randomization).

Can you get pregnant on CIN 2?

The results suggest that treatment for CIN does not adversely affect the chances of a successful conception, although treatment is associated with an increased risk of miscarriage in the second trimester.

How serious are precancerous cells?

Often, precancerous lesions are not invasive and a person will not develop cancer. In some cases these precancerous cells, if left alone, may go on to become “invasive” cancer cells. Sometimes, it may take these cells a few years, or even decades to progress.

Is CGIN worse than CIN?

CGIN is usually classified as low grade (mild) or high grade (severe). High grade CGIN is the equivalent of CIN3. CGIN can be multi-focal – this means that more than one area is affected at one time, with normal tissue lying between them.

Why do I need a second colposcopy?

If cell changes come back, they are usually found after your follow-up appointment. If your cervical screening (smear test) done during this appointment finds high-risk HPV, you will usually have further tests at colposcopy again.

Can CIN 2 come back after LEEP?

About 23% of patients develop CIN2+ after LEEP treatment due to residual or recurrent lesions. The majority of patients with HPV infection were HPV negative before treatment, but 16,4% were still HPV 16 positive after treatment, indicating that conization do not necessarily clear HPV infection rapidly.

Should I get a hysterectomy if I have precancerous cells?

If the precancerous disease is more extensive or involves adenocarcinoma in situ (AIS), and the woman has completed childbearing, a total hysterectomy may be recommended. 1 During a total hysterectomy, the entire uterus (including the cervix) is removed.

What happens if CIN 2 is left untreated?

High-Grade Abnormalities CIN-2 & CIN-3

These cells are more likely to become cancerous and invade deeper layers of the cervix if left untreated. If high-grade abnormalities are detected on a Pap smear, the woman is advised to have a colposcopy and biopsy.

Why do I need a second LEEP procedure?

In some instances, you may need a repeat procedure to remove all the cells completely. You may also need an additional LEEP if abnormal cells return. You're at a greater risk of recurrence if you're infected with a high-risk strain of the human papillomavirus, or HPV.

What is the difference between CIN 1/2 and 3?

CIN 1: Refers to abnormal cells affecting about one-third of the thickness of the epithelium. CIN 2: Refers to abnormal cells affecting about one-third to two-thirds of the epithelium. CIN 3: Refers to abnormal cells affecting more than two-thirds of the epithelium.

Can HPV make you feel unwell?

HPV usually doesn't make you feel sick or cause any symptoms. Your immune system can fight off the infection before you ever know you have it, but you could still spread it to others before that happens. If you do get symptoms, the most common signs of HPV are genital warts.

Will LEEP get rid of HPV?

Although LEEP does not completely eradicate HPV infection, our results indicate that most HR-HPV infections are cleared after LEEP with negative margins. The clearance rate is increasing gradually after surgery. Our persistence rate was 40.9 % at 6 months, 20 % at 12 months and 11.8 % at 18 months.

What happens if colposcopy is abnormal?

You may need treatment if the results of your colposcopy show that there are abnormal cells in your cervix. The abnormal cells will be removed, which usually involves removing an area of the cervix about the size of a finger tip.

How long does it take for HPV to turn into precancerous cells?

If you don't treat an HPV infection, it can cause cells inside your cervix to turn into cancer. It can often take between 10 and 30 years from the time you're infected until a tumor forms.

What are the symptoms of HPV in females?