What is benfotiamine and what are the effects of it?

Benfotiamine is a lipid-soluble derivative of thiamine. The increased lipid solubility of benfotiamine allows it to penetrate nerve cells more easily. After oral intake, benfotiamine shows increased bioavailability compared with an equivalent dose of water-soluble thiamine.

Is it safe to take benfotiamine?

When taken by mouth: Benfotiamine is likely safe at doses of up to 600 mg daily for up to 24 weeks. Side effects are rare, but some people have reported stomach problems and skin rashes.

What is benfotiamine good for?

Benfotiamine is a dietary supplement. It is used to treat diabetic neuropathy (nerve pain) and Alzheimer's disease. Benfotiamine is a lab-created version of thiamine (vitamin B1). Your body absorbs it better than natural B1.

What is the difference between vitamin B1 and benfotiamine?

Benfotiamine is a lab-made version of vitamin B1, also called thiamine. Scientists are studying it to see if it might help conditions like diabetes-related nerve damage, Alzheimer's disease, and alcohol dependence. Early research into the potential benefits of benfotiamine has shown some promise.

Does benfotiamine raise blood pressure?

We found a marked increase in thiamine and thiamine diphosphate in all patients who received benfotiamine (Table 1, both P < 0.001). Diastolic blood pressure (DBP) was also significantly increased in the benfotiamine group (P < 0.01) and was significantly different from the change in the placebo group (P < 0.05).

Vitamin B therapy dangerous for diabetics with kidney disease

Does benfotiamine interact with medications?

Drug-Drug Interactions: BENFOTIAMINE may interact with anti-cancer drugs (fluorouracil). Drug-Food Interactions: Avoiding alcohol may improve the side effects of BENFOTIAMINE. Drug-Disease Interactions: Before using BENFOTIAMINE, let your doctor know if have any liver, kidney and heart diseases.

Is benfotiamine anti inflammatory?

Our studies indicate that benfotiamine is a more potent anti-inflammatory compound as compared to specific LOX and COX inhibitor.

Can benfotiamine lower blood pressure?

There were no significant differences in systolic blood pressure between the control and diabetic animals, and benfotiamine treatment had no effect on blood pressure.

Is benfotiamine good for neuropathy?

Studies have shown that benfotiamine improves neuropathy scores significantly,^301,302 increases nerve conduction velocity,^303-305 and reduces HbA1c and pain. On the Russian market, it is one of the most studied drugs for neuropathic pain.

Can vitamin B1 be harmful?

Toxicity. It is unlikely to reach a toxic level of thiamin from food sources alone. In the setting of very high intakes, the body will absorb less of the nutrient and flush out any excess amount through the urine. There is no established toxic level of thiamin.

Is benfotiamine good for the heart?

Benfotiamine therapy appears to be a potential strategy for preventing diabetic nephropathy, a severe complication of diabetes, associated with a high risk of heart disease and mortality.

What are the best vitamins for nerve damage?

B Vitamins

Vitamins B-1, B-6, and B-12 have been found to be especially beneficial for treating neuropathy. Vitamin B-1, also known as thiamine, helps to reduce pain and inflammation and vitamin B-6 preserves the covering on nerve endings.

Is 50 mg of B1 too much?

A daily dose of 50 to 100 mg is often taken as a supplement. Thiamine appears safe in these doses. But you should talk to your doctor before taking a large amount.

Is benfotiamine safe for liver?

Significance: In conclusion, the treatment with thiamine or benfotiamine even 30min after the massive dose of ethanol has proven to be beneficial against liver damage. Improved results were obtained with benfotiamine in relation to oxidative damage from aqueous compartments.

Is benfotiamine safe for kidneys?

Taken together, these data suggest that benfotiamine protects the peritoneal membrane and remnant kidney in a rat model of peritoneal dialysis and uremia. Peritoneal dialysis (PD) is a well accepted alternative to hemodialysis in the treatment of end-stage renal disease.

How much B1 should you take a day?

How much vitamin B1 do we need? In the U.S., the recommended daily allowance (RDA) of thiamin taken by mouth is 1.2 mg for males and 1.1 mg for females over the age of 18 years. Pregnant or breastfeeding women of any age should consume 1.4 mg each day.

How do you reverse nerve damage in feet naturally?

Exercise releases natural painkillers called endorphins. Exercise also promotes blood flow to the nerves in the legs and feet. Researchers believe that regular exercise may create a long-lasting expansion in blood vessels in the feet, nourishing damaged nerves back to health.

What vitamins are good for neuropathy in the feet?

B vitamins are useful in treating neuropathy since they support healthy nervous system function. Peripheral neuropathy is sometimes caused by a vitamin B deficiency. Supplementation should include vitamin B1 (thiamine and benfotiamine), B6, and B12. You may choose to take these separately instead of as a B complex.

How do you repair nerve damage naturally?

Green and leafy vegetables. Broccoli, spinach and asparagus all contain vitamin B, a nutrient important for nerve regeneration and nerve function. Spinach, broccoli and kale also contain a micronutrient called alpha-lipoic acid that prevents nerve damage and improves nerve function.

Does benfotiamine help with tinnitus?

I began reading reports about benfotiamine which is a much higher absorbable form of vitamin B-1. It works for me. It is 6 weeks now and my tinnitus remains 90 percent gone. Hope this works for you.

Is benfotiamine good for diabetes?

Our findings suggest that high-dose benfotiamine (300 mg/day) supplementation over 24 months has no significant effects upon peripheral nerve function or soluble markers of inflammation in patients with type 1 diabetes.

Can benfotiamine cause headaches?

In prescribing B-complex vitamins, make sure that the patient is not already taking another vitamin supplement that may contain B vitamins. Vitamin B₃ (niacin) in doses greater than 300 mg/day may cause headache, nausea, skin tingling, and flushing.

Can you overdose on benfotiamine?

Overdose. Data regarding Benfotiamine overdose is limited. Overdose is likely, since the vitamin is fat-soluble and excess of it is remained stashed in the body. In case you suspect an overdose, seek emergency medical care immediately....

Is benfotiamine an antioxidant?

Conclusions: Benfotiamine shows a direct antioxidant action. This effect of benfotiamine may be involved in the improvement of diabetic late complications, including peripheral neuropathy.

Does vitamin B1 help with tinnitus?

The good news is that various natural substances have been shown to help provide relief to individuals suffering from tinnitus. These substances include Calcium, Vitamin B1, Vitamin B2, Vitamin B12, Zinc, Gingko biloba, Cytochrome C, Omega-3 Fatty Acids, and certain traditional Chinese herbs.