What is a dangerously high B12 level?

An abnormally high vitamin B-12 status is anything over 900 pg/mL. This result may suggest liver or kidney problems, diabetes, or certain forms of leukemia.

Is very high B12 serious?

Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin.

Is B12 level of 1500 too high?

There is no consensus on the definition of high or elevated B12. Previous studies have chosen a variety of levels to represent high or very high B12 (pmol/l) levels. Some examples include: 664.2¹⁹; 513¹; 700 (high) and 1500 (very high)¹¹; and 601 (high) and 1000 (very high)¹⁰.

What happens if you have too high of B12?

High doses of vitamin B-12, such as those used to treat a deficiency, might cause: Headache. Nausea and vomiting. Diarrhea.

What causes extremely high B12 levels?

Usually, excess vitamin B12 is removed in the urine. Conditions that can increase B12 level include: Liver disease (such as cirrhosis or hepatitis) Myeloproliferative disorders (for example, polycythemia vera and chronic myelogenous leukemia)

Dangers of vitamin B12 deficiency

Is B12 level of 2000 too high?

But a normal level of vitamin B12 in your bloodstream is generally between 190 and 950 picograms per milliliter (pg/mL). Between 200 to 300 pg/mL is considered borderline and your doctor may do more testing. Below 200 pg/mL is low and more testing is needed.

What cancers cause high B12?

In the Danish registry, a B12 > 800 pmol/L (1084 ng/L) was associated with the following cancer sites: pancreas, esophagus and stomach, colon and rectum, lungs, kidneys, urinary bladder, and strongly with liver [14].

How long does it take to get rid of excess B12?

If a person stops consuming the vitamin, the body's stores of this vitamin usually take about 3 to 5 years to exhaust. People should not take high doses of vitamin B12 as a cure-all, but otherwise the vitamin does not appear to be toxic; consuming excess amounts of B12 is not recommended.

Can too much B12 cause neuropathy?

Thus, vitamin B12 may be associated with both sensory and motor peripheral nerve function. In older adults, the prevalence of poor peripheral nerve function and neuropathy is high and increases with age^18–21.

Why would B12 be high without supplements?

High or supraphysiological serum B12 levels without supplementation have been associated with many pathological conditions including renal failure, haematological disorders, cancer, and hepatic or autoimmune diseases. All conditions may show elevated concentrations of B12 transport proteins.

Can high B12 be nothing?

However, it is extremely rare to have a high blood level from too much vitamin B12 in the diet. There are cases where an individual has an elevated vitamin B12 level that is seen as an incidental finding in someone who has not recently received a vitamin B12 injection or taken a vitamin B12 supplement.

How do they treat high B12 levels?

If you're diagnosed with a B-12 deficiency, the goal of treatment is to increase your level of vitamin B-12. Your treatment may include: vitamin B-12 injection, with more frequent injections for those with severe deficiencies. daily vitamin B-12 supplements, such as Cyanocobalamin, which is a manmade vitamin B-12.

Can autoimmune cause high B12?

Abnormally elevated B12 has been attributed many causes [5,6], e.g., myeloid blood malignancies [7,8,9], acute or chronic liver diseases [10,11,12], chronic kidney failure, autoimmune or inflammatory diseases [3], and Gaucher disease [13].

What nerve damage can vitamin B12 cause?

People who are vitamin B-12 deficient may not produce enough myelin to coat their nerves. Without this coating, nerves can become damaged. Problems are more common in the nerves in the hands and feet, which are called peripheral nerves. Peripheral nerve damage may lead to tingling in these parts of the body.

Is B12 neuropathy reversible?

Supplementation for vitamin B₁₂ deficiency should be provided parenterally since poor oral absorption is usually the cause of the disease. Supplementation with vitamin B₁₂ typically halts progression of the disease, but does not reverse it since much of the disability is secondary to the spinal cord pathology.

Can too much vitamin B hurt you?

Consuming vitamin B-6 through food appears to be safe, even in excessive amounts. When used as a supplement in appropriate doses, vitamin B-6 is likely safe. However, taking too much vitamin B-6 from supplements can cause: A lack of muscle control or coordination of voluntary movements (ataxia)

Can high levels of B12 cause insomnia?

At the same time, the influence of B12 directly on sleep isn't clear. Some studies show a connection between low vitamin B12 and insomnia, while other studies show higher levels of vitamin B12 are linked to sleep disruption and shorter sleep times.

Can fatty liver cause high B12 levels?

Six out of eight showed a higher B12 level in NAFLD patients (mean 223.5 to 473.1 pg/mL) when compared to controls (mean 171.9 to 448.0 pg/mL). Seven out of eight studies presented higher HCY levels in NAFLD patients (mean 9.18 to 56.3 umol/L) when compared to controls (mean 8.49 to 19.7 umol/L).

What can I do to lower my B12 level?

Research has suggested that the consumption of alcohol may reduce vitamin B12 levels. An older study indicated that moderate alcohol intake diminished vitamin B12 by 5% among “healthy, well-nourished, postmenopausal women.” Alcohol-related liver disease may falsely increase vitamin B12 test levels.

Can stress cause high B12 levels?

Those who have to deal with highly stressful situations or are in a serious crisis need more vitamin B12 than usual. These situations can be high mental or physical stress such as important exams or difficult tests.

Can too much B12 damage your liver?

Vitamin B12 therapy has not been linked to ALT elevations or to clinically apparent acute liver injury. Likelihood score: E (unlikely cause of liver injury).

Can B12 cause anxiety?

B12 deficiencies are often a root cause of neurological, psychiatric and cognitive issues. Having a B12 deficiency puts you at risk for developing depression and anxiety, fatigue, and can worsen hypothyroid and other health concerns.

Can vitamin B12 cause weight gain?

Despite the numerous processes in which vitamin B12 is involved, there's little evidence to suggest that it has any influence on weight gain or loss.

Can too much vitamin B make you tired?

Too much nicotinic acid can also cause low blood pressure, fatigue, headaches, rashes, and liver damage. Excess nicotinamide. High doses of nicotinamide, another form of vitamin B3, can cause diarrhea and increased bleeding. This can occur in doses of 500 mg per day.

What is normal level of vitamin B12 in elderly?

A serum vitamin B₁₂ level between 200 pg/mL and 900 pg/mL is considered normal, but a threshold of 300 to 350 pg/mL is recognized as a marker for a desirable status in the elderly.