What happens when vitamin B12 is very high?

However, supplementing with excessively high levels of B12 has been linked to some negative side effects. Several studies have shown that megadoses of the vitamin can lead to outbreaks of acne and rosacea, a skin condition that causes redness and pus-filled bumps on the face.

What does it mean if your B12 level is too high?

An abnormally high vitamin B-12 status is anything over 900 pg/mL. This result may suggest liver or kidney problems, diabetes, or certain forms of leukemia.

Is high B12 levels serious?

Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin.

What are the symptoms of high B12 levels?

Is B12 level of 1500 too high?

There is no consensus on the definition of high or elevated B12. Previous studies have chosen a variety of levels to represent high or very high B12 (pmol/l) levels. Some examples include: 664.2¹⁹; 513¹; 700 (high) and 1500 (very high)¹¹; and 601 (high) and 1000 (very high)¹⁰.

What Does A High B12 Level Mean?

Should I be worried about high B12?

Is taking high doses of B12 helpful or harmful? Since B12 is a water-soluble vitamin, it's generally considered safe, even at high doses. No Tolerable Upper Intake Level (UL) has been established for B12, due to its low level of toxicity.

What cancers cause high B12?

Other studies focusing on specific cancers have shown a strong association between elevated B12 levels and liver cancers (OR 3.3 [95%CI: 1.1–10.4] for hepatocellular carcinomas and OR 4.7 [95%CI: 1.2–17.9] for other liver cancers) [16], a moderate association with prostate cancer (OR 1.1 [95%CI: 1.0–1.2]) [17], and no ...

How do I reduce my B12 levels?

Research has suggested that the consumption of alcohol may reduce vitamin B12 levels. An older study indicated that moderate alcohol intake diminished vitamin B12 by 5% among “healthy, well-nourished, postmenopausal women.” Alcohol-related liver disease may falsely increase vitamin B12 test levels.

How long does it take to get rid of excess B12?

If a person stops consuming the vitamin, the body's stores of this vitamin usually take about 3 to 5 years to exhaust. People should not take high doses of vitamin B12 as a cure-all, but otherwise the vitamin does not appear to be toxic; consuming excess amounts of B12 is not recommended.

Can stress cause high B12 levels?

Those who have to deal with highly stressful situations or are in a serious crisis need more vitamin B12 than usual. These situations can be high mental or physical stress such as important exams or difficult tests.

Why would B12 be high without supplements?

High or supraphysiological serum B12 levels without supplementation have been associated with many pathological conditions including renal failure, haematological disorders, cancer, and hepatic or autoimmune diseases. All conditions may show elevated concentrations of B12 transport proteins.

Can you overdose on vitamin B12?

No, you cannot overdose on B12

Vitamin B12 is a water-soluble vitamin, meaning it dissolves in water and is quickly absorbed by the body. It is stored in the liver and whatever your body doesn't use is excreted through urine, Allen says. Even in high doses, your body can only absorb a fraction of B12 supplements.

Can too much B12 cause tingling?

Tingling sensation or Numbness

In some patients, tingling sensation is experienced mostly in the right side of the body. This symptom is one of the early warning indicators of Vitamin B12 overdose.

Can diabetes cause high B12 levels?

Increasing duration of diabetes was associated with higher serum Vitamin B12 levels.

Can autoimmune cause high B12?

Abnormally elevated B12 has been attributed many causes [5,6], e.g., myeloid blood malignancies [7,8,9], acute or chronic liver diseases [10,11,12], chronic kidney failure, autoimmune or inflammatory diseases [3], and Gaucher disease [13].

Is B12 a tumor marker?

Elevated Plasma Vitamin B12 Levels as a Marker for Cancer: A Population-Based Cohort Study. Affiliations of authors:Department of Clinical Epidemiology (JFBA, LP, HTS) and Department of Clinical Biochemistry (JFBA, EN), Aarhus University Hospital, Aarhus, Denmark. Corresponding author.

Can fatty liver cause high B12 levels?

Six out of eight showed a higher B12 level in NAFLD patients (mean 223.5 to 473.1 pg/mL) when compared to controls (mean 171.9 to 448.0 pg/mL). Seven out of eight studies presented higher HCY levels in NAFLD patients (mean 9.18 to 56.3 umol/L) when compared to controls (mean 8.49 to 19.7 umol/L).

Can vitamin B12 cause rapid heartbeat?

There are a variety of symptoms that come with a B12 deficiency. One sign associated with the condition is experiencing heart palpitations. “Your heart may feel like it's pounding, fluttering or beating irregularly, often for just a few seconds or minutes.

Can too much vitamin B12 cause insomnia?

The results suggest that the use of combined multivitamin supplements, as well as single vitamins, including vitamin B complex, hurts sleep maintenance, causes a higher rate of insomnia, and requires greater use of sleep medicine.

Does B12 hurt your stomach?

B12 supplements are usually safe. For adults, doctors recommend 2.4 micrograms a day. If you take more than what you need, your body passes the rest out through your pee. Still, high doses could have some side effects, like dizziness, headache, anxiety, nausea, and vomiting.

Why is my vitamin B12 over 2000?

The most common cause of high B12 in the blood is due to recent ingestion or injection of supplemental vitamin B12. We don't worry about overdosing on B12 supplements because excess can be excreted in your urine. It could also be possibly from your diet if high in animal products such as meat, eggs, and shellfish.

Does vitamin B12 cause weight gain?

Despite the numerous processes in which vitamin B12 is involved, there's little evidence to suggest that it has any influence on weight gain or loss.

How does vitamin B12 affect the nervous system?

Neurological changes

A lack of vitamin B12 can cause neurological problems, which affect your nervous system, such as: vision problems. memory loss. pins and needles (paraesthesia)

What level of B12 causes neurological symptoms?

Patients with neurological symptoms, serum B12 level lower than 200 pg/mL, and with normal folic acid levels were included in the study.

Can B12 nerve damage be reversed?

Most problems due to vitamin B12 deficiency can be treated with vitamin B12 supplementation, but nerve damage may not be reversible even after treatment. The sooner your vitamin B12 deficiency is treated, the more likely it is that your symptoms will go away.