What drugs cause hyperplasia?

Gingival hyperplasia

Gingival hyperplasia

Gingival enlargement is an increase in the size of the gingiva (gums). It is a common feature of gingival disease. Gingival enlargement can be caused by a number of factors, including inflammatory conditions and the side effects of certain medications. The treatment is based on the cause.

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Gingival enlargement - Wikipedia

or gingival overgrowth is a common occurrence in patients taking phenytoin, cyclosporine, or calcium channel blockers.

What drugs are known to cause overgrowth of the gingiva?

What blood pressure medications cause gingival hyperplasia?

Amlodipine, a calcium channel blocker, used as antihypertensive drug has been found associated with gingival hyperplasia.

What can cause gingival hyperplasia?

Gingival hyperplasia can occur as a direct result of inflammation. The inflammation is often caused by plaque buildup on the teeth from food, bacteria, and poor hygiene practices. The inflammation can make the gums tender and red, and it can trigger bleeding.

Can beta blockers cause gingival hyperplasia?

They're often prescribed to patients who can't tolerate beta blockers, another common blood pressure drug. Besides other general side effects, CCBs can also cause gingival hyperplasia (gum overgrowth) and mouth dryness.

Medication Induced Gingival Hyperplasia

Does metoprolol cause gingival hyperplasia?

The frequency of GO was significantly higher in nifedipine-treated cases than other drug groups. Frequency of GO was 75% for nifedipine, 31.4% for amlodipine and 25% for amlodipine + metoprolol. Higher gingival, plaque and calculus were observed in patients taking calcium channel blockers.

Does ACE inhibitors cause gingival hyperplasia?

Among them 71.1% were taking calcium channel blocker, 21.5% were taking ACE Inhibitors, and 7.4% were taking beta-blockers. Conclusions: Patients taking antihypertensive agents are at increased risk for gingival enlargement and inflammation is an important cofactor for the expression of this effect.

Can certain medications cause gingivitis?

One class of drugs known to cause gingival hyperplasia is calcium channel blockers. These drugs treat migraine headaches, regulate mood, and relieve panic attacks. Other drugs that can cause gingival hyperplasia are: amlodipine (Norvasc)

Does gabapentin cause gingival hyperplasia?

The overexpression of these cytokines, obtained in many studies, leads us to think that gabapentin can interact and cause post-inflammatory gingival hyperplasia, but, probably, in our study the gabapentin has not the same effect, because we used gingival fibroblasts of healthy people.

Why do calcium channel blockers cause gingival hyperplasia?

The calcium antagonist induces blockage of the aldosterone synthesis in zona glomerulosa of the adrenal cortex since this pathway is calcium-dependent, cyclic nucleotide-independent. This may produce a feedback stimulation of an increase in pituitary secretion of ACTH which affects zona glomerulosa hyperplasia.

Does calcium channel blockers cause gingival hyperplasia?

Long-term treatment of common chronic cardiac conditions such as hypertension with calcium channel blockers (CCBs) has long been associated with gingival hyperplasia. This oral side effect may affect esthetics and function, yet often overlooked and therefore underreported among Nigerians.

What medications can cause gum problems?

Does HCTZ cause gingival hyperplasia?

Probably, the ability of hydrochlorothiazide to eliminate sodium and water has an anti-hypertrophic effect even at the peripheral cellular level. Gingival overgrowth seems to be a collateral effect that accompanies these medications.

Can antidepressants cause gingival hyperplasia?

Prozac may sometimes contribute to gum irritation and periodontal disease (gingivitis). Zoloft has occasionally been associated with gum overgrowth. Both drugs may dry out the mouth, which can increase the risk of plaque buildup, gum problems and cavities. Many medicines can cause such conditions.

Which antiepileptic drug may cause gingival hyperplasia in patients?

Phenytoin is the drug, which can be chiefly implicated for causing gingival overgrowth.

How is drug-induced gingival hyperplasia treated?

The most effective treatment of drug-related gingival enlargement is withdrawal or substitution of medication. When this treatment approach is taken, it may take from 1 to 8 weeks for resolution of gingival lesions.

Does phenobarbital cause gingival hyperplasia?

CONCLUSION. Different antiepileptic molecules may be related to gingival overgrowth. In addition to phenytoin, also lamotrigine, oxcarbazepine, and phenobarbital were associated with increased prevalence of gingival overgrowth.

What are the side effects to gabapentin?

Does carbamazepine cause gingival hyperplasia?

Gingival hyperplasia was very common in patients taking PHT (16%-94% of patients). Alveolar bone loss occurred in patients taking carbamazepine or PHT. Patients taking valproate, carbamazepine or phenobarbital also had gingival hyperplasia.

Can statins cause gingival hyperplasia?

Although these three medications are of different drug classes, they all can cause drug-induced gingival overgrowth with manifests as enlarged gingival epithelium and connective tissues that exhibits varying degrees of fibrosis and inflammation.

Does methotrexate cause gingival hyperplasia?

Methotrexate is an immunosupressive medication frequently used in the treatment of advanced RA. It does not induce gingival overgrowth but it does produce a high incidence of oral ulceration.

Does propranolol cause gingival enlargement?

The research facts about propranolol give us a fair description about the drug pharmacology and terms it as a safe drug used for the cardiovascular treatment and chronic migraine. Hence, propranolol stands safe as it has got a very low prevalence rate to cause the gingival enlargement but not as a serious threat.

Can antibiotics cause gingival hyperplasia?

Some frequently used medications, in particular antihypertensives, nonsteroidal anti-inflammatory drugs and even antibiotics, can lead to overgrowth of the gingiva and to the multiple unwanted conditions, namely: Lupus erythematosus, erythema multiforme, mucositis, oral lichen planus, pemphigus vulgaris and more.

Does diltiazem cause gingival hyperplasia?

A small study of 89 patients undertaken at the Westside Veterans Administration Medical Center, Chicago seems to indicate that nifedipine and diltiazem do indeed cause gingival hyperplasia.

Does heart medication cause gum disease?

Possible Side Effects

CCBs work by dilating (widening) the blood vessels, which makes it easier for the heart to pump blood. But in a small percentage of people, they also cause changes in the gums. Gum tissue may become thick and lumpy, and it may sometimes extend abnormally and start to cover the teeth.