What does lithium do to your organs?

Taking lithium for long periods can affect your kidneys and your thyroid. Lithium can also cause drowsiness. Your doctor will carry out blood tests regularly to monitor how much lithium is in your blood. They will also monitor your kidney function, your thyroid gland and your parathyroid gland.

What organs can lithium damage?

The three organ systems that may be negatively affected by lithium are the thyroid gland, kidneys and parathyroid glands.

What are the dangers of taking lithium?

Can lithium cause permanent damage?

Rarely, lithium is reported to cause irreversible, permanent neurological sequelae such as cerebellar impairment, dementia, parkinsonian syndromes, choreoathetosis, brain stem syndromes, and peripheral neuropathies.

Can lithium damage your liver?

(Review of the mechanism of action of lithium, its clinical uses and toxicity; states that prolonged exposure to high doses of lithium [above 2 mM] can cause liver injury).

A short history of lithium, and its remarkable impact on mood disorders | Explainer | ABC News

Is lithium hard on kidneys or liver?

Kidney damage due to lithium may include acute (sudden) or chronic (long-term) kidney disease and kidney cysts. The amount of kidney damage depends on how long you have been taking lithium. It is possible to reverse kidney damage caused by lithium early in treatment, but the damage may become permanent over time.

What are the long-term effects of taking lithium?

Lithium also exerts antisuicidal, immunomodulatory, and neuroprotective effects. The main problems associated with long-term lithium treatment include kidney, thyroid, and probably cognitive issues.

Why is lithium rarely prescribed?

It has long been known that lithium has toxic effects on the thyroid gland and the kidneys. The thyroid toxicity, caused primarily by lithium's interference with thyroid hormones' release from the gland (19) affects up to 19% of treated patients (20).

Why do people quit lithium?

Adverse effects were the most common cause for lithium discontinuation. Among the adverse effects, diarrhoea, tremor, creatinine increase, polyuria/polydipsia/diabetes insipidus and weight gain were the top five reasons for discontinuing lithium.

Does lithium decrease life expectancy?

Lithium May Extend Longevity

In addition to the well-known positive effects on mood,¹⁸ lithium has also been linked with longer overall longevity. Two studies have found that individuals living in areas with even modest, low levels of lithium in the drinking water tend to live longer.

What drugs should not be taken with lithium?

Common drug–drug interactions with lithium

The most commonly prescribed drugs that have the potential to interact with lithium are ACE inhibitors, angiotensin II receptor antagonists (sartans), diuretics, and non-steroidal anti-inflammatory drugs (NSAIDs).

What mental illness does lithium treat?

Lithium is a mood stabilizer medication that works in the brain. It is approved for the treatment of bipolar disorder (also known as manic depression). Bipolar disorder involves episodes of depression and/or mania.

Why is lithium hard on kidneys?

The link between lithium and renal dysfunction may be explained by exposure to toxic lithium levels. Toxic levels kill renal cells, and that damage builds up every time the level rises above the toxic line.

Is there an alternative to taking lithium?

Current alternatives to lithium for the prevention of relapse in affective disorder are antidepressants (especially in unipolar illnesses), carbamazepine and maintenance ECT. There are numerous other potential pharmacological agents, in particular val- proate and valpromide.

Is lithium a last resort?

Lithium remains first choice as maintenance treatment for bipolar affective disorder. Yet, about half of all individuals may stop their treatment at some point, despite lithium's proven benefits concerning the prevention of severe affective episodes and suicide.

Why is lithium controversial?

Since its introduction, the prescription of lithium has grown increasingly controversial due to reports of poisoning, memory loss, and the drug having a “lobotomizing effect” on patients.

What is being on lithium like?

When first starting lithium, many people experience common side effects, such as nausea, shakiness, or greater thirst. Regular blood monitoring is important to make sure you are taking a safe and effective dose of lithium.

What is the oldest mood stabilizer?

The oldest and most studied of mood stabilizers is lithium. However, many drugs that were first developed as anticonvulsants to treat epilepsy also act as mood stabilizers. These include carbamazepine, divalproex and lamotrigine.

How does lithium change your personality?

Substantial affect and mood changes are induced by lithium carbonate. Lethargy, dysphoria, a loss of interest in interacting with others and the environment, and a state of increased mental confusion were reported.

What does lithium do to your brain?

At a neuronal level, lithium reduces excitatory (dopamine and glutamate) but increases inhibitory (GABA) neurotransmission; however, these broad effects are underpinned by complex neurotransmitter systems that strive to achieve homeostasis by way of compensatory changes.

How common is kidney failure with lithium?

Although several reports suggest little effect of lithium on renal function, other studies estimate prevalence of chronic kidney disease (CKD) amongst lithium users between 10 and 35% (Presne et al.

How long does it take to detox from lithium?

The NICE guidelines for bipolar disorder recommend that you gradually reduce your dose of lithium over at least four weeks. Ideally, you would reduce it over a period of up to three months. This is to lower your risk of relapse.

What is an alternative to lithium for bipolar?

The ones that treat bipolar depression are cariprazine (Vraylar), lurasidone (Latuda), olanzapine-fluoxetine combo (Symbyax), and quetiapine (Seroquel). Among them, lurasidone offers a good balance of efficacy and tolerability.

Is lithium a miracle drug?

A naturally occurring salt, lithium has been dubbed both a miracle drug and the gold standard in the treatment of bipolar disorder, alternatively—and perhaps more descriptively—known as manic-depressive disorder.

Why do schizophrenics take lithium?

Lithium stabilises a person's mood and is used as an add‐on treatment with antipsychotics for schizophrenia. Lithium can reduce mania and depression.