What does desmopressin treat?

Desmopressin is used to treat central cranial diabetes insipidus. This is a condition that causes the body to lose too much fluid and become dehydrated. It is also used to control bedwetting (nocturnal enuresis), and the frequent urination and increased thirst caused by certain types of brain injury or brain surgery.

What conditions does desmopressin treat?

Desmopressin (DDAVP®) is used to help stop bleeding in patients with von Willebrand's disease or mild hemophilia A. DDAVP causes the release of von Willebrand's antigen from the platelets and the cells that line the blood vessels where it is stored.

What does desmopressin do to urine?

Results: Desmopressin significantly increased urine osmolality, decreased nocturnal total urine volume, reduced the ratio of nocturnal urine volume-to-whole day urine volume and decreased nocturnal voiding frequency.

What are side effects of desmopressin?

What is desmopressin target?

Desmopressin is a drug that acts on the vasopressin receptors of the body. It has many relevant clinical uses, ranging from nocturnal enuresis to hemophilia.

Desmopressin (Noctiva) - Uses, Dosing, Side Effects | Pharmacist Review

Is desmopressin an antidiuretic?

Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body.

Who uses desmopressin?

Desmopressin is used to treat central cranial diabetes insipidus. This is a condition that causes the body to lose too much fluid and become dehydrated. It is also used to control bedwetting (nocturnal enuresis), and the frequent urination and increased thirst caused by certain types of brain injury or brain surgery.

Does desmopressin hurt your kidneys?

The doctor may need to stop or adjust desmopressin treatment, especially in children and older adults. Children may be more sensitive to the side effects of this drug, especially water/mineral imbalance and a low level of sodium in the blood. Kidney function declines as you grow older.

Can you take desmopressin long term?

Desmopressin is the medicine commonly used to treat bedwetting. It can be used both short-term (eg, for a school trip or a sleepover) and long-term.

Who should not take desmopressin?

tell your doctor if you have or have ever had kidney disease or a low level of sodium in your blood. Your doctor will probably tell you not to take desmopressin. tell your doctor if you have or have ever had high blood pressure, any condition that causes you to be extremely thirsty, cystic fibrosis, or heart disease.

Does desmopressin cause fluid retention?

Desmopressin leads to renal water retention, and iatrogenic hyponatremia may result if fluid intake is not appropriately restricted.

What happens if you drink water after taking desmopressin?

If you take too much desmopressin or drink too much fluid while taking it, it can cause your body to retain too much water. This can result in: headaches. dizziness.

Does desmopressin cure bedwetting?

DDAVP. DDAVP (desmopressin acetate) mimics the natural hormone that causes the kidneys to conserve body water and concentrate the urine, decreasing urine output during sleep. DDAVP: Significantly improves bedwetting in 25 to 65 percent of children; 12 to 40 percent of kids achieve complete dryness.

Does desmopressin cause hypertension?

Infrequently, desmopressin may affect your blood pressure. It may cause an increase or decrease in your blood pressure. A temporary drop in your blood pressure may result in dizziness and a fast heartbeat. Ask your doctor for more details, especially if you have heart problems or high or low blood pressure.

Does desmopressin increase sodium?

Desmopressin can be given to increase the urine concentration and reduce free-water loss, thereby limiting autocorrection of serum sodium level. It is vital that this be done carefully, and the patient must have strict fluid restrictions or have no enteral intake.

Can desmopressin be used for adults?

Recently, a new brand of desmopressin sublingual tablet (lyophilisate-an orally disintegrating tablet; Noqdirna-Ferring) has been licensed for use in adults of any age for the treatment of nocturia due to idiopathic nocturnal polyuria.

What medications interact with desmopressin?

How safe is desmopressin?

Treatment with intranasal and oral formulations of desmopressin is generally well tolerated, and side effects are usually minor. The risk of hyponatraemia, although small, can be reduced by adhering to the indications, dosing recommendations and precautions when prescribing desmopressin.

Can you drink water with desmopressin?

Limit your intake of water and other fluids while you are using desmopressin. Drinking too much water may lead to a serious, life-threatening electrolyte imbalance. Fluid restriction is especially important in children and older adults using desmopressin.

Does desmopressin cause insomnia?

DDAVP nasal spray has been infrequently associated with somnolence, lethargy, paresthesias, fatigue, confusion, stupor, malaise, diaphoresis, itchy or light-sensitive eyes, insomnia, chills, warm feeling, and agitation.

How long does it take for desmopressin to start working?

After an injection is given, desmopressin usually starts to work within 15 to 30 minutes.

How is diabetes insipidus diagnosed?

What is another name for desmopressin?

Desmopressin, sold under the trade name DDAVP among others, is a medication used to treat diabetes insipidus, bedwetting, hemophilia A, von Willebrand disease, and high blood urea levels.

Can desmopressin cause low sodium?

Desmopressin can induce significant hyponatremia leading to very severe neurologic consequences for patients. The management can be complex, as discontinuation of desmopressin can lead to profuse diuresis and a rapid rise in sodium levels as a result of suppressed antidiuretic hormone levels.

What disease is caused by deficiency of ADH?

Central diabetes insipidus (DI) is caused by a deficiency in antidiuretic hormone (ADH) and is characterized by polyuria in response to exogenous ADH analog2).