What cancers cause high ferritin levels?

Iron overload, inflammation, liver disease, and malignancy are conditions that lead to elevated serum ferritin [7-11]. Pancreatic cancer, colorectal cancer, lung cancer, T-cell lymphoma, and hepatocellular carcinoma are associate with high serum ferritin [7-12].

What cancers have high ferritin levels?

Ferritin is often elevated in the serum of cancer patients including those with neuroblastoma (63), Hodgkinson's lymphoma (64), cervical (65), oral squamous cell (66), renal cell (67), T cell lymphoma (68), CRC (69), and breast (70) cancers and were often associated with increased tumor grade and shorter survival.

Does high ferritin mean cancer?

An elevated serum ferritin level is reportedly associated with pathologic immunosuppression, proliferation, and angiogenesis, and could be an indicator of malignant disease.

What is the most common cause of high ferritin levels?

A doctor would expect higher than normal ferritin levels in people with these and other inflammatory conditions. The most common causes of elevated ferritin levels are obesity, inflammation, and daily alcohol intake. The most common causes of genetic-related elevated ferritin levels is the condition hemochromatosis.

Can a ferritin blood test detect cancer?

Ferritin: Extremely elevated levels of ferritin may indicate Hodgkin disease or leukemia. Thyroglobulin: Elevated levels of this hormone may indicate follicular cancer.

Iron Levels and Breast Cancer

Is ferritin a tumor marker?

Ferritin: a tumor marker expressed by renal cell carcinoma.

Can colon cancer cause high ferritin levels?

Ferritin was statistically associated with gastrointestinal/colorectal cancer only in patients with anaemia, and areas under the curve performed better in these patients than in the whole sample (AUC = 0.799, CI: 0.688-0.910 for gastrointestinal cancer, and 0.839, CI: 0.765-0.913 for colorectal cancer) (Table 5).

Should I be worried about high ferritin levels?

If a ferritin test shows higher than normal levels, it could indicate that you have a condition that causes your body to store too much iron. It could also point to liver disease, rheumatoid arthritis, other inflammatory conditions or hyperthyroidism.

What inflammation causes high ferritin?

Summary. There is increasing evidence that circulating ferritin levels may not only reflect an acute phase response but may play a critical role in inflammation. MAS, AOSD, cAPS and septic shock are associated with very high levels of ferritin.

What is considered a dangerously high ferritin level?

Many laboratories consider serum ferritin levels greater than 200 ng/mL in women and greater than 300 ng/mL in men to be abnormal.

Can pancreatic cancer cause high ferritin levels?

Ferritin was found to be increased in 73% of pancreatic cancer patients; it was also abnormal in 40% of chronic pancreatitis and in 38% of extra-pancreatic diseases. Patients with chronic pancreatitis studied during a relapsing phase all had elevated serum ferritin.

What causes sudden increase in ferritin?

Raised serum ferritin can be caused by five main mechanisms: damage to ferritin-containing tissues, for example, the bone marrow and liver; inflammation or infection, because ferritin is an acute-phase protein; genetic iron-loading conditions; secondary iron-loading conditions, which are mainly due to blood ...

Does lung cancer cause high ferritin?

Elevated serum ferritin levels were seen more often in lung cancer patients (82%) than in those with the non-malignant disorders (52%). The levels of ferritin were also affected by the extension of the disease.

What happens if your ferritin is too high?

High levels of ferritin can damage your joints, heart, liver, and pancreas. Too much iron is most often caused by an inherited disease called hemochromatosis. Many people with this disease never have any symptoms, especially women who lose iron through menstruation.

Can you have high iron levels and not have hemochromatosis?

Conclusion. In a patient with signs and symptoms of tissue iron overload and high serum ferritin levels, low or normal transferrin saturation should alert the physician to other - primary as well as secondary - causes of iron overload besides hemochromatosis.

How is ferritin an inflammatory marker?

We argue here that serum ferritin arises from damaged cells, and is thus a marker of cellular damage. The protein in serum ferritin is considered benign, but it has lost (i.e. dumped) most of its normal complement of iron which when unliganded is highly toxic.

Does lupus cause high ferritin levels?

Serum and urine ferritin levels are increased in patients with lupus. Ferritin levels in serum and urine of healthy (N = 3), SLE (N = 5) and LN (N = 5) patients were determined using a protein array (Raybiotech, Norcross, GA, USA).

What autoimmune disease causes high iron levels?

Hereditary hemochromatosis (he-moe-kroe-muh-TOE-sis) causes your body to absorb too much iron from the food you eat. Excess iron is stored in your organs, especially your liver, heart and pancreas.

Can rheumatoid arthritis cause high ferritin levels?

Other selected etiologies of elevated ferritin include: chronic inflammatory connective tissue diseases (such as rheumatoid arthritis and adult onset Stills disease), lymphoma, hepatitis B, C, alcoholic and non-alcoholic liver disease.

What liver disease causes high ferritin levels?

An elevated serum ferritin level is associated with some chronic liver diseases such as nonalcoholic fatty liver disease, nonalcoholic steatohepatitis,⁴ steatosis caused by HCV, and liver fibrosis progression⁵ and is also related to HCV treatment outcome.

Can fatty liver cause high ferritin levels?

Abstract. Serum ferritin (SF) levels are commonly elevated in patients with nonalcoholic fatty liver disease (NAFLD) because of systemic inflammation, increased iron stores, or both.

What does a ferritin level of 500 mean?

In a healthy man in his 30s or 40s, a stable elevated ferritin level of 500 – 600 μg/l is suggestive of preclinical hereditary haemochromatosis. Mildly elevated serum ALT and fatigue, as in our patient, are common initial symptoms of the transition to clinical stage disease.

What are the symptoms of gastrointestinal cancer?

What are the symptoms of right sided colon cancer?

A persistent change in your bowel habits, including diarrhea or constipation or a change in the consistency of your stool. Rectal bleeding or blood in your stool. Persistent abdominal discomfort, such as cramps, gas or pain. A feeling that your bowel doesn't empty completely.

Does cancer affect iron levels?

While there are several types of anemia, iron deficiency anemia is the type that is most often linked to cancer. Iron deficiency anemia is caused by a lack of healthy red blood cells in the body. There are several cancers that can attack blood cells, causing anemia.