What can be mistaken for Paget's disease?

The symptoms of Paget disease of the breast are often mistaken for those of some benign skin conditions, such as dermatitis or eczema (1–3).

Can Paget's disease of the bone be misdiagnosed?

Bone involvement in PDB is usually asymmetric, and true cysts have not been described in this disease (10, 12–14). He had no lytic lesions on the skull, enlargement of bone on radiological analyses, deformity or fractures, which along with repeatedly normal AP levels, led us to suspect the misdiagnosis of PDB.

How do you rule out Paget's disease?

An X-ray can show whether your bones have become enlarged as a result of Paget's disease of bone. Sometimes a bone scan called scintigraphy may also be carried out to check how much of your body is affected by the condition. For this scan, a small amount of a radioactive substance is injected into your blood.

Is Paget's disease always cancer?

Paget's disease is a sign that there might be breast cancer in the tissues behind the nipple. It is possible for someone to have Paget's of the breast with no underlying cancer but this is less common. About half of the people diagnosed with Paget's disease have a lump behind the nipple.

How do you tell if you have Paget's disease?

Paget Disease of Bone Radiology, Symptoms and Treatment

How quickly does Pagets disease progress?

Mammary Paget's disease is associated with carcinoma of the underlying lactipherous ducts. The skin lesions progress slowly over months as scaly, fissured, or oozing erythema of the nipple and areola. Advanced lesions may appear as well-demarcated, eczema-like plaques with a pink or red hue.

What does early Paget's disease look like?

Symptoms of Paget's disease of the nipple

Paget's disease of the nipple always starts in the nipple and may extend to the areola. It appears as a red, scaly rash on the skin of the nipple and areola. The affected skin is often sore and inflamed, and it can be itchy or cause a burning sensation.

Can ultrasound detect Paget's disease?

Ultrasound is used not only to confirm the mammography findings in a case of Paget's disease, but also when the mammogram is negative. The findings on ultrasound include heterogeneous hypoechoic areas in breast parenchyma, presence of a discrete mass or dilated ducts.

Is Paget's disease painful?

Symptoms can include: constant, dull bone pain. joint pain, stiffness and swelling. a shooting pain that travels along or across the body, numbness and tingling, or loss of movement in part of the body.

What blood tests show Paget's disease?

The most important one for diagnosing Paget's disease is a blood test for alkaline phosphatase, an enzyme made by bone. If the level of this enzyme is high, your doctor will want to do other tests. You might also need other tests, such as an MRI or a CT scan.

Which test can help distinguish Paget's from malignant bone disease?

Lab tests. People who have Paget's disease of bone usually have elevated levels of alkaline phosphatase in their blood, which can be revealed by a blood test.

What virus causes Paget's disease?

In most cases, no specific cause for Paget's disease can be identified (sporadic). Research findings suggest that Paget's disease may be related to a “slow virus” infection of bone, a condition that is present for many years before symptoms appear.

What of the following is the most common appearance of Paget's disease?

Paget's disease can affect any bone in the skeleton. It appears most often in the spine, pelvis, long bones of the limbs, and skull. It can be present in just one bone or in several bones.

How long do people with Paget's disease live?

The 5-year survival rate for a patient with Paget disease and sarcoma is 5-7.5%; however, it may be as high as 50% for those who undergo operative tumor ablation and chemotherapy before metastases occur. The 5-year survival rate for elderly patients with primary nonpagetic sarcoma is 37%.

Which is the first line treatment for Paget's disease?

Bisphosphonates are first-line therapy for Paget's disease, and the advent of the new bisphosphonates permits a dramatic improvement in treatment.

How aggressive is Paget's disease?

As a noninvasive form of cancer, Paget's is not considered an aggressive or fast-moving disease, but it is often associated with another cancer in the same breast.

Do symptoms of Pagets disease come and go?

In most cases, Paget's disease affects one breast, and the symptoms may come and go. This means symptoms may cycle through, appearing to improve and then worsen again. The symptoms may look similar to eczema or other such skin conditions.

Do you need chemo for Paget's disease?

After your operation, your doctor may recommend additional treatment (adjuvant therapy) with anti-cancer drugs (chemotherapy), radiation therapy or hormone therapy to prevent a recurrence of breast cancer.

How can you tell the difference between Paget's disease and eczema?

Paget's disease may affect your nipple, while eczema rarely affects your nipple. Paget's disease also typically only affects one breast, while eczema affects both breasts and other parts of your chest. Paget's disease won't respond to the same treatments as eczema.

Can an MRI detect Paget's disease?

More recently, breast MRI has been identified as a modality which may improve detection of clinically and mammographically occult breast malignancies associated with Paget's disease [2-5].

Does Pagets disease show up on a MRI?

Conclusions: Paget disease of the breast associated with underlying DCIS can be diagnosed at MRI of the breast and therefore impact management decisions.

Is Paget's disease an autoimmune disease?

Paget's disease of bone is a chronic autoimmune inflammatory disease that leads to an increase in bone reabsorption. While depression is extensively described in Paget's disease, affecting up to 50% of patients, the prevalence of manic episodes is unknown.

What is the most common initial site of Paget's disease?

Paget's disease usually begins in the cancellous bone of an epiphysis or metaphysis. A diaphysis is the first site involved in some instances, and the anterior subperiosteal area of the proximal half of the tibia in a very small number of cases.

What is the most common age to be diagnosed with Paget's disease?

Age. People older than 50 are most likely to develop the disease. Sex. Men are more commonly affected than are women.