What autoimmune disease causes lichen planus?

Results: Among patients with LP, there were significant associations with systemic lupus erythematosus (SLE) (multivariate odds ratio [mOR]: 2.87; 95% CI: 1.97-4.17), Sjögren's syndrome (mOR: 3.75; 95% CI: 2.66-5.28), dermatomyositis (mOR: 6.34; 95% CI: 1.82-22.16), vitiligo (mOR: 2.09; 95% CI: 1.31-3.32) and alopecia ...

What autoimmune disorder causes lichen planus?

Etiology of Lichen Planus

Lichen planus (LP) is thought to be caused by a T cell–mediated autoimmune reaction against basal epithelial keratinocytes in people with genetic predisposition.

Is lichen planus linked to autoimmune diseases?

Lichen planus is a chronic inflammatory dermatosis of autoimmune origin that usually manifests in the oral mucosa.

What diseases are linked to lichen planus?

Lichen planus is a cell-mediated immune response of unknown origin. It may be found with other diseases of altered immunity; these conditions include ulcerative colitis, alopecia areata, vitiligo, dermatomyositis, morphea, lichen sclerosis, and myasthenia gravis.

What triggers lichen planus?

The cause of lichen planus is usually not known, although possible causes include: Hepatitis C, a virus that attacks your liver. Certain medicines, including some drugs used to treat high blood pressure, diabetes, heart disease, and malaria. Reactions to metal fillings in your teeth.

Lichen Planus (“Purple Skin Lesions”) | Causes, Signs

Can vitamin D deficiency causes lichen planus?

The VDR receptor protects against invasion of microbes into the underlying connective tissue, and in the case of the oral lichen planus, epithelial destruction means apoptosis or planned cell death (15). Vitamin D deficiency results in impaired T cell proliferation and may therefore lead to the development of OLP.

Does Covid 19 cause lichen planus?

Despite viruses being reported as a triggering factor in oral lichen planus, very few cases of oral lichen planus after COVID-19 infection were noticed. The immunological and psychological changes induced by COVID-19 infection may explain the tendency to find lichen planus lesions in COVID-19 patients.

Is lupus and lichen planus related?

Lupus erythematosus (LE) and lichen planus (LP) are two distinct and well established dermatoses which occasionally can occur as an overlap syndrome. Overlap syndrome is characterized by mixed clinical and histopathological features of both LE and LP.

Does lupus cause lichen planus?

Lupus erythematosus lichen planus (LE-LP) overlap syndrome remains an uncommon diagnostic entity, combining both the histologic and clinical features of lupus erythematosus and lichen planus. A rare and challenging diagnosis, clinicopathologic correlation is essential for accurate and timely identification.

What is the difference between lupus and lichen planus?

Lichen planus (LP) is a chronic inflammatory mucocutaneous disorder with unknown etiology. Systemic lupus erythematosus (SLE) is known as a prototypic autoimmune disease. Cytokines play a key role in the pathogenesis of both diseases.

Can Sjogren's cause lichen planus?

As a result, atrophic lesions of the mucosa are a common observation in cases of Sjogren's syndrome and other salivary gland diseases. These epithelial changes can occur in both the skin and mucous membranes in cases of lichen planus.

Can lichen planus cause a positive ANA test?

Lichen planus (LP) is a mucocutaneous syndrome of yet uncertain pathogenesis, and it has usually been considered to be a dermatosis without antinuclear antibodies (ANA) nor other specific auto-antibodies.

Is lichen planus life threatening?

Although lichen planus is a disease of uncertain cause and is difficult to be cured by treatment, this skin disease itself is neither life threatening like cancer nor infectious. Therefore, lichen planus is very unlikely to affect your general health and cannot be passed on.

Can hypothyroidism cause lichen planus?

Oral Lichen planus (OLP) is an autoimmune mucocutaneous disease. There are some reports of thyroid diseases, especially hypothyroidism, to have association with OLP in some studies.

Can lichen planus spread to other parts of the body?

Symptoms of lichen planus

purplish-colored lesions or bumps with flat tops on your skin or genitals. lesions that develop and spread over the body for several weeks or a few months. itching at the site of the rash, which commonly appears on the wrists, lower back, and ankles.

What foods should you avoid if you have lichen planus?

They'll likely hurt the most when you eat or drink foods that are spicy, salty, acidic (orange juice, tomatoes), or alcoholic. Crispy treats and drinks with caffeine can also cause problems. Your doctor can diagnose oral lichen planus by taking a small piece of skin from inside your mouth.

Can lichen planus be misdiagnosed?

Your GP may be able to make a diagnosis based on the characteristic rash. However, lichen planus can be mistaken for other skin conditions, such as eczema, which also causes the skin to become red, flaky and itchy.

What is lichen lupus?

Lichen planus (LIE-kun PLAY-nus) is a condition that can cause swelling and irritation in the skin, hair, nails and mucous membranes. On the skin, lichen planus usually appears as purplish, itchy, flat bumps that develop over several weeks.

Is lichen planus a disability?

The Veteran's lichen planus is currently rated as 60 percent disabling by analogy to Diagnostic Code 7806 for dermatitis or eczema.

What specialist deals with lichen planus?

Dermatologists often diagnose lichen planus by from the appearance of the rash. When it's not clinically obvious a skin biopsy may be required.

Is lichen planus inherited?

The exact cause of lichen planus is unclear. Many believe it is an autoimmune disorder, where the immune system mistakenly attacks healthy tissues. The following is known about lichen planus: It does not appear to be a hereditary condition.

What blood pressure medications cause lichen planus?

Medications commonly reported to trigger a lichenoid drug eruption include: Antihypertensives – ACE inhibitors, beta-blockers, nifedipine, methyldopa. Diuretics – hydrochlorothiazide, frusemide, spironolactone. Non-steroidal anti-inflammatory drugs (NSAIDs)

Can HPV cause lichen planus?

In the present study, HPV 18 genome was found in 31% of OLP lesions and 7.1 % of controls. In 2009, Szarka¹⁶ reported that HPVs may be involved in the development or progression of potentially malignant oral lesions including oral lichen planus.

What is the difference between lichen planus and lichen sclerosus?

The main difference between the two conditions is that LP has a propensity to involve the mucous membranes including the mouth and vagina which are rarely affected in LS. First-line treatment for LS is a super-potent topical corticosteroid ointment which has a high response rate.

Can the flu shot cause lichen planus?

Although influenza vaccine is thought to be effective and safe, it occasionally causes systemic reactions such as toxic epidermal necrolysis, bullous pemphigoid, lichen planus (LP), etc. The period of increased risk of developing these events was different depending on the immune responses induced by the vaccination.