What are the side effects of pergolide in horses?

Pergolide is FDA approved for use in horses and has been evaluated for safety. In field trials, decreased appetite occurred but was usually transient. Weight loss, anorexia, diarrhea, colic, lethargy, and behavioral changes have been observed in some horses. CNS effects may include ataxia and dyskinesia.

What are the side effects of Prascend in horses?

Side effects

Prascend® is well tolerated in horses. Potential adverse reactions in horses include inappetence, transient anorexia and lethargy, mild central nervous system signs (e.g. mild depression, mild ataxia and mild hyperexcitability), diarrhoea and colic. These signs are usually mild and transient in nature.

Can pergolide cause laminitis?

In some cases laminitis developed for the first time during pergolide treatment, in other cases laminitis recurred or did not improve during pergolide treatment. When considering treatment options clinicians should weigh the potential benefits of treatment against the risk of adverse effects.

How long does it take for pergolide to work on a horse?

Pergolide does not accumulate in the horse's body, and steady levels of pergolide are realized within three days of starting treatment; Pergolide is cleared from the system quickly, with a half-life less than 12 hours; and.

Can pergolide cause colic?

Pergolide may also cause stomach and intestinal upset and may cause symptoms of colic in your horse.

Prascend® (pergolide tablets) Testimonial: Image

Can Prascend cause lameness?

Increased or decreased sweating may occur. Reproductive cycles may be abnormal or absent, potentially leading to infertility. A cause of lameness in both forelimb and hindlimb of athletic horses. Fat deposits may appear along the crest of the neck and the tail head.

Is pergolide safe for horses?

Pergolide is FDA approved for use in horses and has been evaluated for safety. In field trials, decreased appetite occurred but was usually transient. Weight loss, anorexia, diarrhea, colic, lethargy, and behavioral changes have been observed in some horses.

What is the difference between PRASCEND and pergolide?

A. Pergolide is the name of the drug, i.e. the active ingredient (pergolide mesylate). Prascend is the only form of pergolide that is currently licensed for use in horses. It is made by Boehringer Ingelheim and comes in 1 mg tablets, which can be easily broken in half.

Is Cushing's painful for horses?

As long as horses with Cushing's disease are treated and monitored closely for any signs of pain (due to laminitis) or other abnormal characteristics of decreased quality of life, they are not thought to be suffering.

How do you feed a horse pergolide?

PRASCEND is contraindicated in horses with hypersensitivity to pergolide mesylate or other ergot derivatives. Preserved and protected in foil blister packs, the single-scored tablets make it simple to adjust dosage. Administer orally at a starting dose of 2 mcg/kg once daily.

How long can horses be on PRASCEND?

24-month stability at labeled storage conditions which allows for consistent, reliable dosing. PRASCEND is for use in horses only.

Do all Cushings horses get laminitis?

Equine Cushing's cases always develop laminitis if they live long enough. They may become immunosuppressed and subject to a variety of parasitic or infectious agents such as helminthiasis or pneumonia. Many cases show muscle loss and become polydipsic and polyphagic; they may be diabetic.

What happens if Cushing's is left untreated in horses?

If a horse has untreated Cushing's Disease, it is more likely to develop laminitis and the laminitis will be more difficult to control. If an equine has any of the clinical signs suggestive of Cushing's, a blood sample can be taken to check ACTH levels in the blood.

Can you take a horse off PRASCEND?

Currently the USEF rule states that horses must be pulled off of Prascend 24 hours prior to competition. This does not benefit the horse as he or she can experience increased ACTH levels and thus increased levels of the body's own steroid production during that time.

Does PRASCEND cause loss of appetite?

Treatment with PRASCEND may cause loss of appetite. Most cases are mild. If severe, a temporary dose reduction may be necessary. Weight loss, lack of energy, and behavioral changes also may be observed.

What is the best hay to feed a horse with Cushing's?

Alfalfa averages 10-15% NSC, and oat hay is very high, averaging 22%. Alfalfa can be a good option for a horse with Cushings if they are a hard time holding their weight because it is more calorie-dense than grass hay.

Should you blanket a horse with Cushings?

Since Cushing's disease makes it hard for your horse to stay cool in warm weather and warm in cool weather, blanket him in the winter as necessary, and body-clip him in the summer if necessary. Be sure he has shade, shelter, and access to fresh water.

Can a horse with Cushings live out?

Your vet and farrier will need to work together to keep your horse comfortable for as long as possible. Eventually, if not stricken by other mortalities, most horses with Cushing's fall victim to severe laminitis and have their lives ended by euthanasia.

Why was pergolide taken off the market?

FDA today announces that manufacturers of pergolide drug products, which are used to treat Parkinson's disease, will voluntarily remove these drugs from the market because of the risk of serious damage to patients' heart valves.

What is pergolide half life?

Conclusions and clinical relevance: With an elimination half-life of approximately 6 hours, twice-daily dosing may be more appropriate than once-daily dosing to reduce peak-trough fluctuation in pergolide concentrations.

Does pergolide cause weight loss?

Findings from this study suggest that treatment with pergolide may promote weight loss and improve insulin regulation in horses with PPID, but does not impact muscle mass or markers of muscle proteolysis. Keywords: Adiposity; Equine; Insulin; Proteolysis; Weight loss.

Is pergolide safe to handle?

Pergolide, like other ergot derivatives, may cause emesis, dizziness, lethargy or low blood pressure. Pregnant or lactating women should wear gloves when administering this product. Store this product separately away from human medicinal products and handle this product with care to avoid accidental ingestion.

What does pergolide treat for horses?

Pergolide is widely prescribed to treat Cushing's Disease in horses.

Does pergolide need to be refrigerated?

Compounded pergolide formulations in aqueous vehicles should be stored in a dark container, protected from light, and refrigerated and should not be used >30 days after produced. Formulations that have undergone a color change should be considered unstable and discarded.

Can PRASCEND help laminitis?

Several studies report improvement in the clinical signs of laminitis during treatment with pergolide. However, such improvements cannot be attributed to pergolide rather than other interventions such as farriery, rest or analgesia.