What are the long term effects of metronidazole?

Patients should be monitored for adverse effects such as peripheral or central neuropathy (such as paraesthesia, ataxia, dizziness, convulsive seizures), particularly if metronidazole has been prescribed for long-term use.

Can metronidazole cause permanent damage?

Serious side effects of Flagyl and Flagyl ER include brain disease, fevers, mouth sores, painful urination, nerve damage resulting in prickling or tingling sensations that may become permanent, cystitis, pelvic pain or pressure, decreased sex drive, inflammation of the lining of the rectum, inflammation of the mouth ...

Is metronidazole hard on your body?

It can give you severe side effects such as feeling or being sick, stomach pain, hot flushes, difficulty breathing, a pounding heartbeat (palpitations) and headaches.

How long can you safely take metronidazole?

Adults—500 or 750 milligrams (mg) 3 times a day for 5 to 10 days. Children—Dose is based on body weight and must be determined by your doctor. The dose is usually 35 to 50 milligrams (mg) per kilogram (kg) of body weight per day, divided into 3 doses, for 10 days.

How long is too long for metronidazole?

If you need to take metronidazole for longer than ten days, your doctor may want you to have some tests. Make sure you keep any appointments that your doctor gives to you.

Metronidazole - Mechanism of action, Side effects, and Uses [1/31]

Can you take metronidazole for months?

If you're prescribed metronidazole cream or gel for rosacea, you'll normally use it twice a day for about 2 months. Treatment can sometimes last longer. Follow the instructions from your doctor or pharmacist.

Can metronidazole affect your brain?

There have been several reported cases in which abnormalities of the brain on MRI were associated with metronidazole treatment: lesions involving the subcortical white matter, splenium, midbrain, and cerebellar dentate nuclei.

Can metronidazole be given long term?

Metronidazole can be given long term if needed for pets with chronic colitis. If a pet doesn't tolerate metronidazole we can substitute something else. It usually takes 10-14 days of medication to completely clear a typical infection and sometimes longer.

What to avoid when taking metronidazole?

You should not drink alcoholic beverages or take other alcohol-containing preparations while you are using this medicine and for at least 3 days after stopping it. If you have trichomoniasis: Using this medicine while you are pregnant (especially during the first 3 months of pregnancy) can harm your unborn baby.

What foods should you avoid when taking metronidazole?

Alcohol, avocados, bananas, chocolate, salami

Do not mix these items with drugs such as metronidazole (Flagyl) and linezolid (Zyvox), used to treat bacterial infections.

Is metronidazole a harsh antibiotic?

Metronidazole is a very safe and effective antibiotic medication used to treat bacterial vaginosis (BV). Many users will not experience any negative Metronidazole side effects at all and will have a very positive experience with the medication on the whole.

What does metronidazole do in the human body?

Metronidazole is an antibiotic. It's used to treat skin infections, rosacea and mouth infections, including infected gums and dental abscesses. It's also used to treat conditions such as bacterial vaginosis and pelvic inflammatory disease.

Can metronidazole weaken immune system?

Birth control: Ingredients in metronidazole vaginal cream may cause condoms and diaphragms to become less effective. Alternative forms of birth control should be considered while using this medication. Blood cell counts: This medication may cause low white blood cell counts, which can mean your immune system is weak.

Is metronidazole cancerous?

MTZ is potentially carcinogenic to humans due to the following facts: it is a proven mutagen in bacterial systems, it is genotoxic to human cells and also, it is carcinogenic to animals.

Can you overuse metronidazole?

In cases of severe overdoses, it can cause some cardiac arrhythmias among other life-threatening complications. A common culprit of these cardiac complications is the co-ingestion of metronidazole with another medication that can cause these complications when present in excess.

Can metronidazole damage your liver?

The liver injury from metronidazole is rare, but can result in liver failure and death. In typical cases, recovery is expected in 1 to 3 months. Rechallenge results in prompt recurrence and should be avoided.

What is the best time of day to take metronidazole?

Metronidazole extended-release tablets are usually taken once daily at least 1 hour before or 2 hours after a meal for 7 days. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take metronidazole exactly as directed.

Can I take probiotics with metronidazole?

Yes, you SHOULD take probiotics and antibiotics at the same time! ✓ Taking probiotics and antibiotics together is more effective than taking antibiotics alone. ✓ Probiotics reduce antibiotic side effects, including antibiotic-associated diarrhea.

Can you take metronidazole for 6 months?

Recommended treatment for recurrent BV consists of an extended course of metronidazole treatment (500 mg twice daily for 10-14 days); if ineffective, metronidazole vaginal gel 0.75% for 10 days, followed by two times per week for 3-6 months, is an alternate treatment regimen.

How many times can you take metronidazole for BV?

Metronidazole is available as an oral pill or vaginal gel; the choice of pill or gel is based on the person's preferences. The oral pill is taken twice daily for seven days. The gel is inserted into the vagina at bedtime for five days. Both treatments work equally well.

How much metronidazole is too much?

Adults—Dose is based on body weight and must be determined by your doctor. The dose is usually 7.5 milligrams (mg) per kilogram (kg) of body weight every 6 hours for 7 to 10 days. Your doctor may increase your dose as needed. However, the dose is usually not more than 4000 mg per day.

Can metronidazole cause mental changes?

Metronidazole is known to cause CNS side effects like paresthesia, cerebellar symptoms, syncope, confusion, psychosis, encephalopathy, etc.

Can metronidazole cause mental health issues?

Metronidazole can cause psychosis; it is thought to be a result of inhibition of monoamine oxidase (MAO), a dopamine catabolizing enzyme. Psychosis generally resolves within 14 days of discontinuation. Contributing factors for psychosis include the concurrent use of disulfiram and supratherapeutic metronidazole levels.

How common is metronidazole toxicity?

Neurological toxicity is fairly common with this drug, however majority of these are peripheral neuropathy with very few cases of central nervous toxicity reported.