What are the long term effects of duloxetine?

Are There Any Risks For Taking Duloxetine For Long Periods Of Time? To date, there are no known problems associated with long term use of duloxetine. It is a safe and effective medication when used as directed.

What does duloxetine do to the brain?

Cymbalta inhibits the reuptake of serotonin and norepinephrine in the central nervous system. It also increases dopamine by acting on dopamine reuptake pumps, thus increasing the diffusion of dopamine in the brain.

How long should you be on duloxetine?

How long you take duloxetine for depends on why you're taking it. For depression or anxiety, once you're feeling better, it's likely that you'll continue to take it for several more months. Most doctors recommend that you take antidepressants for 6 months to a year after you no longer feel depressed or anxious.

What are the long term effects of taking Cymbalta?

Side effects of Cymbalta include nausea, dry mouth, and constipation. Cymbalta is not addictive when taken properly, although withdrawal symptoms can occur. Long-term effects of Cymbalta may include appetite changes and weight gain.

Is duloxetine hard to get off of?

Duloxetine withdrawal can be especially difficult for some people. This is most common for people who have been taking Cymbalta for a long time, people who take a high dosage of the medication, or people who take multiple antidepressants.

? Duloxetine Side Effects Dosage Uses Warnings and Interactions

Does your brain go back to normal after antidepressants?

"The fact that antidepressant withdrawal can be so prolonged suggests that the drug has changed the brain and that those changes are taking a very long time to return to normal and it may be the case that sometimes they don't go back to normal."

Is 60 mg of duloxetine a lot?

For treatment of depression: Adults—40 milligrams (mg) per day (given as 20 mg two times per day) to 60 mg per day (given either once a day or as 30 mg two times per day). Your doctor may increase your dose as needed. However, the dose is usually not more than 120 mg per day.

Can I take duloxetine long term?

Are There Any Risks For Taking Duloxetine For Long Periods Of Time? To date, there are no known problems associated with long term use of duloxetine. It is a safe and effective medication when used as directed.

What are the worst side effects of Cymbalta?

Tell your doctor right away if any of these serious side effects occur: confusion, easy bruising/bleeding, decreased interest in sex, changes in sexual ability, muscle cramps/weakness, shaking (tremor), difficulty urinating, signs of liver problems (such as nausea that doesn't stop, stomach/abdominal pain, vomiting, ...

What happens when you stop taking duloxetine?

If you have been instructed to stop taking duloxetine, ask your doctor how to slowly decrease the dose. This will decrease your chance of having withdrawal symptoms such as dizziness, nausea, headaches, vomiting, increased sweating, irritability, nightmares, trouble with sleeping, or prickling or tingling feelings.

How long can you take duloxetine for nerve pain?

Duloxetine at 60 mg daily is effective in treating painful diabetic peripheral neuropathy in the short-term to 12 weeks with a risk ratio (RR) for 50% pain reduction at 12 weeks of 1.65 (95% confidence interval (CI) 1.34 to 2.03), number needed to treat (NNT) 6 (95% CI 5 to 10).

Does duloxetine make you gain weight?

Conclusion: Duloxetine-treated patients experienced weight loss after short-term treatment, followed by modest weight gain on longer-term treatment. The size of the weight changes observed suggests that the antidepressant duloxetine has minimal effects on weight for the majority of patients.

Does Cymbalta change your personality?

Some people may find themselves more frustrated, irritable or lacking in patience when taking the drug. Occasionally this can escalate to open hostility towards others, extreme agitation and even mania. These effects may be more apparent early on in treatment or after discontinuation.

Can duloxetine cause heart problems?

Increased blood pressure and heart rate have been reported in duloxetine trials. The proposed mechanism for duloxetine-induced tachycardia is its effects on norepinephrine, which impact the cardiovascular system.

How long can you take Cymbalta?

Once Cymbalta begins to work, clinical guidelines for depression suggest using pharmacological treatment options for at least 4 to 12 months. Many people who choose to take Cymbalta for mental health conditions and chronic pain continue treatment long term. In some cases, your doctor may stop prescribing Cymbalta.

What should I avoid while taking Cymbalta?

What drugs and food should I avoid while taking Cymbalta (Duloxetine)? Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen, naproxen, Advil, Aleve, Motrin, and others. Using an NSAID with duloxetine may cause you to bruise or bleed easily.

Does duloxetine affect your eyes?

Eye pain, changes in vision and swelling or redness in or around the eye are mentioned as possible visual side effects in the medication of duloxetine. The ocular and visual side effects from a patient's systemic medication can range from mild to severe.

Is Cymbalta worth the risk?

The prominent consumer group Public Citizen indicates that the antidepressant Cymbalta should not be taken for any of the approved uses, as there no evidence that the benefits outweigh the risk of serious and potentially life-threatening side effects associated with the medication.

Can duloxetine cause bowel problems?

Common side effects of taking Duloxetine are:

diarrhoea. difficulty sleeping.

Does duloxetine cause joint pain?

These drugs, however, can cause significant pain in women's joints and muscles. The clinical trial showed that duloxetine (Cymbalta®), which is approved to treat depression and anxiety as well as fibromyalgia and nerve pain caused by diabetes, provided some relief from pain associated with aromatase inhibitors.

Can Cymbalta cause Parkinson's?

The findings indicate that side effects of Cymbalta had the strongest association, with users seeing a risk of Parkinson's disease and EPSs five times higher than those who did not take the drug. Remeron, Celexa, Lexapro and Paxil carried more than three times the risk.

Can duloxetine cause hair loss?

Skin reactions: Skin reactions can include rash and even hair loss. Hair loss and other skin conditions typically were reversible. Glaucoma: While exceptionally rare, there have been reported cases of duloxetine-induced bilateral acute angle-closure glaucoma.

Which is better for nerve pain gabapentin or Cymbalta?

The results showed that, at the end of the study, duloxetine was significantly superior to gabapentin in terms of the incidence of adverse reactions (RR = 0.59, 95% CI: 0.45–0.79, < 0.01), sleep interference score (SMD = −0.35, 95% CI: −0.63 to −0.08, < 0.05), but no significant differences in VAS score (SMD = −0.14, ...

Is Cymbalta good for arthritis pain?

Clinical trials showed that taking Cymbalta significantly reduced chronic pain, compared with a placebo. More than 29,000 patients used Cymbalta in clinical trials, including people with osteoarthritis and chronic low back pain.

Can duloxetine cause high blood pressure?

Duloxetine (Cymbalta). Used for the treatment of depression, anxiety, and chronic pain, Duloxetine raises systolic blood pressure by 2 to 4 points at approved doses. Higher doses of Duloxetine cause greater elevations in blood pressure and thus an increased risk of adverse cardiovascular events.