Is there an alternative to desmopressin?

Alternatives to desmopressin as pharmacologic therapy for DI include synthetic vasopressin and the nonhormonal agents chlorpropamide, carbamazepine, clofibrate (no longer on the US market), thiazides, and nonsteroidal anti-inflammatory drugs (NSAIDs).

What is the difference between vasopressin and desmopressin?

Desmopressin, a synthetic form of the human hormone vasopressin, limits the amount of water eliminated in the urine. It can be administered nasally, via IV, orally, or given as a sublingual tablet. Major uses of desmopressin include bed-wetting, nighttime urination, clotting disorders, and diabetes insipidus.

Can desmopressin be taken long term?

Desmopressin is the medicine commonly used to treat bedwetting. It can be used both short-term (eg, for a school trip or a sleepover) and long-term.

Is there a generic for desmopressin?

Desmopressin Acetate is a generic prescription drug manufactured by Sun, Sagent, Teva, and other generic manufacturers. Brand-name Desmopressin Acetate is available as DDAVP, Minirin, Octostim, Nocdurna, and Stimate.

Who should not take desmopressin?

tell your doctor if you have or have ever had kidney disease or a low level of sodium in your blood. Your doctor will probably tell you not to take desmopressin. tell your doctor if you have or have ever had high blood pressure, any condition that causes you to be extremely thirsty, cystic fibrosis, or heart disease.

NCLEX Question Review - Desmopressin

Does desmopressin hurt your kidneys?

The doctor may need to stop or adjust desmopressin treatment, especially in children and older adults. Children may be more sensitive to the side effects of this drug, especially water/mineral imbalance and a low level of sodium in the blood. Kidney function declines as you grow older.

What is an adverse effect of desmopressin?

SIDE EFFECTS: Headache, nausea, upset stomach, or flushing of the face may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

How much does desmopressin cost?

The cost for desmopressin injectable solution (4 mcg/mL) is around $262 for a supply of 10 milliliters, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.

Can desmopressin cause weight gain?

A: If you drink large volumes of fluids and take too much desmopressin, your body may become overloaded with fluid, which could result in headaches, dizziness and abnormal weight gain.

Is DDAVP the same as desmopressin?

Desmopressin, sold under the trade name DDAVP among others, is a medication used to treat diabetes insipidus, bedwetting, hemophilia A, von Willebrand disease, and high blood urea levels.

Does desmopressin cause memory loss?

The results confirm that memory impairment is a common side-effect of ECT and suggest that desmopressin may prevent ECT-induced memory impairment by its effects on memory and the learning process.

How do I wean off desmopressin?

After a few months of being dry at a particular dose, you may want to wean off the medicine. If so, try taking one less tablet each night for two weeks until you have weaned to one tablet each night. Then try taking the medicine every other day for a month and then stop the DDAVP entirely.

How safe is desmopressin?

Treatment with intranasal and oral formulations of desmopressin is generally well tolerated, and side effects are usually minor. The risk of hyponatraemia, although small, can be reduced by adhering to the indications, dosing recommendations and precautions when prescribing desmopressin.

Does desmopressin affect potassium?

Conclusions: Desmopressin reduces nocturnal urine volume and nocturnal voiding frequency in male patients with nocturnal polyuria. However, increased calcium and decreased potassium excretion following desmopressin treatment deserve attention particularly when it is used on a long-term basis.

Does desmopressin affect blood pressure?

Infrequently, desmopressin may affect your blood pressure. It may cause an increase or decrease in your blood pressure. A temporary drop in your blood pressure may result in dizziness and a fast heartbeat. Ask your doctor for more details, especially if you have heart problems or high or low blood pressure.

Can you take ibuprofen with desmopressin?

ibuprofen desmopressin

Using desmopressin together with ibuprofen may increase the risk of developing water retention and a condition known as hyponatremia, which is caused by an abnormal decrease in blood sodium concentration. In severe cases, hyponatremia can lead to seizures, coma, and even death.

What happens if you drink after taking desmopressin?

Desmopressin Interactions with Alcohol

Alcohol may reduce the effect of desmopressin. Avoid drinking alcohol while taking desmopressin.

How long can a child take desmopressin?

If the medication works, use it for three to six months and then gradually taper the dose over several weeks. DDAVP is safe and often effective, but it's important to use it only at bedtime to reduce the risk of fluid overload and electrolyte abnormalities.

What happens if you drink too much water on desmopressin?

Drinking too much water may lead to a serious, life-threatening electrolyte imbalance. Call your doctor right away if you have signs of low sodium: headache, confusion, muscle cramps, severe weakness, vomiting, loss of coordination, and feeling restless or unsteady.

Do you need a prescription for desmopressin?

Desmopressin is similar to a hormone that is produced in the body. It acts on the kidneys to reduce the flow of urine. This medicine is available only with your doctor's prescription.

What is the brand name for desmopressin?

Desmopressin is a prescription medication used to treat Diabetes Insipidus, Hemophilia A, Von Willebrand Disease (Type 1), Nocturnal Enuresis, Nocturia, Uremic Bleeding in Acute or Chronic Renal Failure. Desmopressin is available under the following different brand names: DDAVP, Stimate, Minirin, Noctiva, Nocdurna.

What is Minirin used for?

Minirin tablets are indicated for the treatment of: cranial diabetes insipidus; primary nocturnal enuresis, in patients from 6 years of age with normal ability to concentrate urine, who are refractory to an enuresis alarm, or in whom an enuresis alarm is contraindicated or inappropriate.

What drugs interact with desmopressin?

When is the best time to take desmopressin?

Desmopressin lasts eight hours so it must be taken just before your child goes to sleep and there must be no drinks until eight hours after it has been taken. It can be more effective to take Desmopressin an hour before going to sleep so that it's already working on slowing wee production as your child goes to bed.

Can desmopressin cause depression?

Adverse Effects of Desmopressin

Although extremely rare, fluid intoxication associated with desmopressin overdosage can lead to central nervous system disturbances, including depression, increased salivation, vomiting, ataxia, muscle tremors, coma, and convulsions.