Is there a generic xiaflex?

Xiaflex is available in a generic form as collagenase Clostridium histolyticum.

What is the cost of Xiaflex?

Doctors who administer the drug will have to be specially trained and certified. Pain, swelling and bruising can develop in the injection area. Xiaflex costs $3,300 an injection, so a full course of eight injections would cost about $26,000, in addition to a doctor's fee.

Why is Xiaflex no longer available?

The decision to withdraw is not based on safety or efficacy concerns. Despite best efforts to appropriately educate the government and the market on XIAFLEX® over the past several years, the product did not receive government reimbursement approval and demand for the product has remained unsustainably low.

Is Xiaflex over the counter?

XIAFLEX is a prescription medicine used to treat adult men with Peyronie's disease who have a "plaque" that can be felt and a curve in their penis greater than 30 degrees when treatment is started. It is not known if XIAFLEX is safe and effective in children under the age of 18. Do not receive XIAFLEX if.

How many times can you have Xiaflex?

No more than 3 injections, each 4 weeks apart, should be given in the same area. If you are using this medication to treat Peyronie's disease, the medication is injected into the plaque in the penis by your healthcare provider.

Optimizing Outcomes with Xiaflex Injections

What is the success rate of XIAFLEX?

Success rates vary but studies demonstrate an average 34% improvement in the curvature (or 17-degree decrease from baseline curvature). 60% of men getting Xiaflex experienced improvement compared to 30% with placebo.

Does XIAFLEX increase size?

Xiaflex with first generation PTT devices also had not impact on length. When patients used RestoreX along with the injection treatment, they experienced a nearly 2cm gain in length or about 17%.

Is there a pill to cure Peyronie's disease?

The U.S. Food and Drug Administration today approved a new use for Xiaflex (collagenase clostridium histolyticum) as the first FDA-approved medicine to treat men with bothersome curvature of the penis, a condition known as Peyronie's disease.

Is there a pill for Peyronie's disease?

Pills. Pentoxifylline (Trental) is often the first medicine doctors prescribe to help straighten the penis. You have to take the pill for a few months to see if it's going to work. Some doctors prescribe vitamin E supplements or a form of potassium called para-aminobenzoate, but there is little evidence these work.

Does Viagra help with Peyronie's disease?

There is currently no evidence to support the use of Viagra or any other oral pills or supplements for the management of Peyronie's disease. Viagra has not been shown to improve the curvature or the deformity that is associated with Peyronie's disease. As such, it is not recommended.

Why was xiapex withdrawn?

The withdrawal was at the request of the marketing authorisation holder, Swedish Orphan Biovitrum AB (publ), which notified the European Commission of its decision to permanently discontinue the marketing of the product for commercial reasons.

Why is XIAFLEX no longer available in Canada?

Notice : The Xiaflex was recently withdraw from the Canadian market by the US pharmaceutical company Endo for financial reasons. This drug is therefore no longer distributed in Canada. It is possible to obtain it through special permission from Health Canada.

What is XIAFLEX made from?

Xiaflex (collagenase clostridium histolyticum) is a biologic drug made from a mixture of proteins derived from Clostridium histolyticum bacteria. It works by breaking down excessive buildup of collagen, a structural protein in connective tissue.

How much is the injection for Peyronie's disease?

In 2013, CCH injections became the first FDA-approved drug treatment for Peyronie's, indicated for men with palpable plaque and curvature of at least 30 degrees. The treatment costs around $4,000 per injection, with a standard therapeutic course involving eight total injections.

Are XIAFLEX injections covered by insurance?

This is considered a cosmetic use and therefore not covered under the medical benefit.

Does Aetna pay for XIAFLEX?

Aetna considers continuation of collagenase clostridium histolyticum (Xiaflex) injections medically necessary for the treatment of Dupuytren's contracture when all of the following criteria are met: The member meets all initial selection criteria; and. The member is continuing with a treatment course for the same cord.

What is the newest treatment for Peyronie's disease?

Xiaflex (collagenase clostridium histolyticum) is an FDA approved prescription medicine that is administered by a trained professional only. Xiaflex is injected directly into the hardened tissue in two courses, and the area is massaged to successfully break down the scar tissue.

How do you break up Peyronie's scar tissue?

Injections that go right into the scar tissue are able to break down the scar and improve the curvature in the penis. Medications can be used in the acute phase, or in men who aren't sure if they want surgery. Medications rarely result in a straight penis.

Does Vitamin D Help Peyronie's?

Transforming growth factor beta-1 (TGF-β1) plays a major role in the pathogenesis of Peyronie's disease (PD). Vitamin D modulates the profibrotic effects of TGF-β1, as shown in recent studies. Therefore, vitamin D deficiency might be a contributing factor in the pathogenesis of PD.

Is Cialis good for Peyronies?

Medications prescribed for erectile dysfunction (Viagra, Levitra, Cialis) are sometimes beneficial for patients in the early stages of Peyronie's disease.

Is Magnesium Good for Peyronie's disease?

Of the 10 patients initially treated with topical magnesium sulfate, three (30%) had improvement in curvature while six (60%) experienced a decrease in plaque size. The average improvement in degrees of curvature was 14.1%. The average decrease in plaque size was 20.3%.

What vitamins should I take for Peyronie's disease?

Vitamin E is commonly used to treat Peyronie's disease.

Can you get length back after Peyronie's disease?

For men with a high degree of curvature and good erectile function, partial incision and grafting is likely to maintain penile length and may gain length in some men, though risk of post-operative ED is significant.

Does Peyronie's plaque go away?

Peyronie disease often happens in a mild form that heals on its own in 6 to 15 months. There is no cure for Peyronie disease. A wide variety of medicines may be tried. Most are taken by mouth, but some are injected into the plaque.

Can XIAFLEX make peyronies worse?

Xiaflex can cause serous damage to the structure of the penis. After treatment, one of the tubes inside the penis could break during an erection, called penile fracture. This typically requires surgery. Damage to the penis may not get better after penile fracture, even with surgery.