Is Premarin made from pregnant horses?

2.7.

Premarin is a highly prescribed orally administered estrogen. It is also available as a topical cream. This estrogenic product is isolated from the urine of pregnant horses (PREgnant MARes' urINe). It has been used for hormone replacement therapy for postmenopausal women in the USA since 1942.

Does Premarin cream have horse urine?

The estrogen-replacement drug Premarin, prescribed to menopausal women, is made from horse urine; in fact, the drug's name is short for PREgnant MARes' urINe. About 750,000 mares are impregnated each year for the sole purpose of collecting their estrogen-rich urine.

Are horses slaughtered for Premarin?

The vast majority of Premarin mares give birth to a foal every year. Afterward, they are almost immediately impregnated again. If they fail to become pregnant, they are sent to slaughter. If they do become pregnant again, their foals are taken from them at the premature age of just three to four months.

How do they make Premarin?

Premarin is created by collecting the urine of pregnant mares. The mares are kept in small standing stalls in order to limit their movement, so not to displace the urinary bladder bags used to collect every drop of urine.

What is pregnant mare urine used for?

PMU is used to produce estrogen and hormone-replacement drugs such as Premarin, PremPro and PremPhase, and DUAVEE, a “PremPro-Lite” which contains Premarin. PMU drugs are made by keeping mares constantly pregnant and collecting their estrogen-rich urine.

The Bitter Truth About Premarin

What is the best alternative to Premarin?

Is Premarin cruel?

Premarin mares are forcibly impregnated over and over again to continually produce high levels of estrogen for Premarin products; their pregnancies last for 11 months, then they are impregnated again after giving birth – a cruel, physically exhausting, non-stop cycle for mares.

Does all HRT contain horse urine?

Bio-identical HRT

In the USA, the original (and until recently) the only licensed form of HRT available on a prescription was made from horse urine. It came under the name “Premarin” (PREgnant MARes urINe).

Is Premarin natural or synthetic?

Synthetic hormones (such as Premarin and Provera) do not have the same molecular structure as the hormones in your body, but your body converts them to a usable form. Bioidentical hormones have developed a reputation as being “natural,” and therefore presumed to be safer than synthetic hormones.

Is estradiol made from horse urine?

From menarche to menopause, estradiol is the primary estrogen responsible for inducing puberty and maintaining feminization. In 1942, Wyeth produced the first FDA-approved estrogen replacement therapy; namely, Premarin, which is isolated from PREgnant MARes' urINe (PMU) and is a mixture of conjugated equine estrogens.

What is a Premarin foal?

PMU stands for Pregnant Mare's Urine and is a product of the pharmaceutical industry and production of hormone replacement therapy drugs such as Premarin and Prempro.

Where does synthetic estrogen come from?

In contrast, synthetic hormones do not have a chemical structure that is identical to a woman's natural hormones. Synthetic hormones are produced by synthesis, and manufacturers synthesize estrogen and progestin using urine from pregnant mares.

Is Premarin still being produced?

Yet the drug is still made and sold; indeed, the FDA recently gave the manufacturer permission to market a new Premarin-based drug meant to treat osteoporosis as well as menopause.

Can you take Premarin if you are allergic to horses?

There is still no mention that this is an animal-based product, other than a warning that people who are allergic to animals should not use Premarin.

Is Premarin Made in China?

Growth of the PMU industry in China

Eventually, China will be the primary, if not the single, source of all Premarin products. And for good reason. Over the last several years, there has been a wealth of research that has been conducted in China with respect to PMU and CEEs.

Is there a natural alternative to estrogen cream?

The most widely cited natural remedy is soy, which is very high in phytoestrogens, or plant estrogens. Other sources are red clover and flaxseed, both of which are available as supplements.

Is progesterone made from horse urine?

Most of your hormone articles are about Premarin, made from the urine of pregnant horses, combined with Provera, an artificial progesterone.

Are steroids made from horse urine?

Introduction. Ethylestrenol and stanozolol are anabolic steroids which can be used to increase muscle mass and enhance performance. These drugs have been linked to instances of doping in race horses.

What is bioidentical estrogen made from?

Topic Overview. Bioidentical hormones (also called bioidenticals) are made in a laboratory. They are made from compounds found in plants (usually soybeans or wild yams). After the plant-based hormone is processed, its structure is said to be identical to the estrogen, progesterone, or androgen hormone your body makes.

Why is there no generic for Premarin?

The answer lies in how Premarin is made. The estrogens in Premarin come from—wait for it—the urine of pregnant mares. Since Premarin comes from horse urine, the exact ingredients have not been defined, and the FDA will not approve a synthetic version. Moral of the story: We may never see a Premarin generic.

Is there a vegan HRT?

Transdermal (which means it is absorbed through the skin) oestradiol (e.g. gels and patches) is suitable for vegans.

Does HRT contain animal products?

Oestrogens used in the HRT drugs Prempak C and Premarin, manufactured by Wyeth-Ayerst, are extracted from the urine of pregnant horses. More than 45,000 of the animals are farmed each year, mainly in the Canadian provinces of Alberta, Manitoba and Saskatchewan.

Is vagifem made from horse urine?

Premarin and Vagifem are examples of vaginal E₂ regimens. Premarin or conjugated equine estrogen (CEE) is a naturally occurring E₂ derived from urine of mares.

Are horses used for HRT?

Certain forms of old-fashioned/traditional HRT are derived from horses' urine (specifically, the urine of pregnant mares). These types of HRT are known as conjugated equine estrogens (CEEs).

Who invented Premarin?

Premarin, a complex of conjugated equine estrogens manufactured by Wyeth for use as hormone replacement therapy in women, was originally developed by the Canadian pharmaceutical firm Ayerst, McKenna and Harrison. The name Premarin was coined from pregnant mare urine, from which the estrogen complex was isolated.