Is Prascend harmful to dogs?

Dogs have eaten PRASCEND tablets that were placed in food intended for horses or dropped during administration of the tablets to the horses. Adverse reactions may occur if animals other than horses ingest PRASCEND tablets. PRASCEND Tablets should not be crushed due to the potential for increased human exposure.

What are the side effects of PRASCEND?

Side effects

Prascend® is well tolerated in horses. Potential adverse reactions in horses include inappetence, transient anorexia and lethargy, mild central nervous system signs (e.g. mild depression, mild ataxia and mild hyperexcitability), diarrhoea and colic. These signs are usually mild and transient in nature.

How long does it take for PRASCEND to take effect?

How long until I see an improvement with my horse after beginning treatment with PRASCEND? Depending on the specific clinical sign, improvement may be observed beginning within 30 days and continue through 6 months of initial treatment.

Can PRASCEND be given every other day?

Giving 0.5 mg every other day - the datasheet states that Prascend should be given once daily. As the average half life of pergolide has been found to be around 6 hours in horses (Abra Wright Pharmacokinetics of pergolide in normal mares, MSc thesis 2009), extending the time between doses seems counter-intuitive.

Does PRASCEND prevent laminitis?

Any potential benefits of pergolide on laminitis would depend on the circumstances of each patient and their pretreatment risk of laminitis but current evidence does not support the widespread use of pergolide to prevent laminitis.

Prascend® (pergolide tablets) Testimonial: Spirit’s Surprising Diagnosis.

Do all Cushings horses get laminitis?

Equine Cushing's cases always develop laminitis if they live long enough. They may become immunosuppressed and subject to a variety of parasitic or infectious agents such as helminthiasis or pneumonia. Many cases show muscle loss and become polydipsic and polyphagic; they may be diabetic.

How do you feed PRASCEND?

Does Prascend cause loss of appetite?

Treatment with PRASCEND may cause loss of appetite. Most cases are mild. If severe, a temporary dose reduction may be necessary. Weight loss, lack of energy, and behavioral changes also may be observed.

What is the difference between Prascend and pergolide?

A. Pergolide is the name of the drug, i.e. the active ingredient (pergolide mesylate). Prascend is the only form of pergolide that is currently licensed for use in horses. It is made by Boehringer Ingelheim and comes in 1 mg tablets, which can be easily broken in half.

Can you crush Prascend?

PRASCEND tablets should not be crushed due to the potential for increased human exposure and care should be taken to minimize exposure when splitting tablets.

Can Prascend cause lameness?

Increased or decreased sweating may occur. Reproductive cycles may be abnormal or absent, potentially leading to infertility. A cause of lameness in both forelimb and hindlimb of athletic horses. Fat deposits may appear along the crest of the neck and the tail head.

How many pills come in a box of Prascend?

It is available in

Single or packs of 160 tablets.

Why was pergolide taken off the market?

FDA today announces that manufacturers of pergolide drug products, which are used to treat Parkinson's disease, will voluntarily remove these drugs from the market because of the risk of serious damage to patients' heart valves.

What is generic for Prascend?

Pergolide mesylate is a synthetic ergot derivative and is a potent dopamine receptor agonist. The chemical name of pergolide mesylate is 8β-[(Methylthio) methyl]-6-propylergoline monomethanesulfonate.

Does Prascend cause diarrhea?

Treatment with Prascend may cause loss of appetite, lethargy, diarrhea, and other behavioral changes. The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated.

Can you overdose a horse on PRASCEND?

Highlights. Pergolide overdose in horses is rare. Side effects of pergolide overdose in horses are related to dopaminergic central nervous effects. Paraffin oil and activated charcoal via a nasogastric tube might prevent systemic absorption of pergolide if overdosed.

Who makes Prascend?

1. PRASCEND® (pergolide tablets) [package insert]. St. Joseph, MO: Boehringer Ingelheim Vetmedica, Inc.; 2011.

Can a Cushings horse have grass?

Pasture grasses can have a high NSC content, especially during the spring and fall seasons, and the risk of colic and laminitis is greater when horses are on pasture. Since laminitis and founder are more common in horses with Cushing's disease, pasture grazing should be severely limited or totally avoided.

What happens if you don't treat Cushings in horses?

If a horse has untreated Cushing's Disease, it is more likely to develop laminitis and the laminitis will be more difficult to control. If an equine has any of the clinical signs suggestive of Cushing's, a blood sample can be taken to check ACTH levels in the blood.

Does Cushing's cause lameness?

The lamellae suspends and supports the pedal bone within the hoof capsule. When these lamellae are disrupted, the pedal bone sinks and rotates which then causes lameness. Cushings causes a break down in the lamellae proteins and reduces lamellae blood flow. This is why horses with Cushings are predisposed to laminitis.

Does pergolide cause weight loss?

Findings from this study suggest that treatment with pergolide may promote weight loss and improve insulin regulation in horses with PPID, but does not impact muscle mass or markers of muscle proteolysis. Keywords: Adiposity; Equine; Insulin; Proteolysis; Weight loss.

How much does pergolide for horses cost?

Shedding and increased energy levels are usually the first signs of improvement. Aside from the initial loss of appetite, long-term treatment with pergolide has one significant drawback– cost. The average monthly cost for treatment with pergolide is $60.

Can pergolide cause colic?

Pergolide may also cause stomach and intestinal upset and may cause symptoms of colic in your horse.

Is pergolide toxic to dogs?

In dogs, no adverse effects at a dose of 0.1mg/kg/day were noted in a one-year study, however clinical signs of vomiting and lethargy have been noted with doses as low as 0.01-0.07mg/kg. The lethal dose is stated to be 25mg/kg in dogs.