Is Pagets disease painful?

Symptoms can include: constant, dull bone pain. joint pain, stiffness and swelling. a shooting pain that travels along or across the body, numbness and tingling, or loss of movement in part of the body.

Is there pain with Paget's disease?

When Paget's disease of bone occurs in an area where nerves pass through the bone, such as the spine and skull, the overgrowth of bone can compress and damage the nerve, causing pain, weakness or tingling in an arm or leg or hearing loss.

Is Paget's disease serious?

Over time, enlarged or misshapen bones can stress nearby joints leading to osteoarthritis in those joints. In very rare cases, Paget's can turn into a life-threatening cancerous bone disease. Severe Paget's disease may cause damage to the heart.

Does Paget's disease of the breast hurt?

Symptoms of Paget's disease of the nipple

Paget's disease of the nipple always starts in the nipple and may extend to the areola. It appears as a red, scaly rash on the skin of the nipple and areola. The affected skin is often sore and inflamed, and it can be itchy or cause a burning sensation.

What initial symptom of Paget's disease is?

Early symptoms of Paget's disease include bone pain, joint pain (especially in the back, hips and knees), and headache. Physical signs include enlargement and bowing of the thighs (femurs) and lower legs (tibias), and enlargement of the skull in the area of the forehead.

Pain, treatment and surgery: Keith's experience of Paget's Disease

What are the three phases of Paget's disease?

The key histopathological feature of Paget disease involveS the bone architecture and includes the three phases of the disease: mixed, osteolytic, and osteosclerotic. These phases may occur at the same time or separately.

What of the following is the most common appearance of Paget's disease?

Paget's disease can affect any bone in the skeleton. It appears most often in the spine, pelvis, long bones of the limbs, and skull. It can be present in just one bone or in several bones.

Does Paget's disease of the breast come and go?

In most cases, Paget's disease affects one breast, and the symptoms may come and go. This means symptoms may cycle through, appearing to improve and then worsen again. The symptoms may look similar to eczema or other such skin conditions.

Will a mammogram show Paget's disease?

Paget's disease of the breast is misdiagnosed due to the fact that it presents itself in a way that resembles eczema. Unless the physician is familiar with the disease, they do not know what to look for. It does not show up on a typical mammogram or ultrasound.

How can you tell the difference between Paget's disease and eczema?

Paget's disease may affect your nipple, while eczema rarely affects your nipple. Paget's disease also typically only affects one breast, while eczema affects both breasts and other parts of your chest. Paget's disease won't respond to the same treatments as eczema.

What is the life expectancy of someone with Paget's disease?

In that study, the British General Practice Research Database identified 2465 patients diagnosed with Paget's disease of bone from 1988 to 1999; retrospective review indicated that 5-yr survival was 67% in patients with Paget's disease compared with 72% in control patients.

Can you survive Paget's disease?

According to NCI's Surveillance, Epidemiology, and End Results program, the 5-year relative survival for all women in the United States who were diagnosed with Paget disease of the breast between 1988 and 2001 was 82.6 percent.

How can you tell the difference between muscle and bone pain?

Bone pain usually feels deeper, sharper, and more intense than muscle pain. Muscle pain also feels more generalized throughout the body and tends to ease within a day or two, while bone pain is more focused and lasts longer. Bone pain is also less common than joint or muscle pain, and should always be taken seriously.

Is Paget's disease a form of arthritis?

Sometimes, this bone pain, which is the most common symptom of the disease, is mistaken for arthritis or other disorders. Generally, symptoms develop slowly, and the disease does not spread to normal bones. Paget's disease can affect any bone, but usually occurs in: Spine.

How do you rule out Paget's disease?

A simple blood test can be carried out to check the level of a substance called alkaline phosphatase (ALP) in your blood. People with Paget's disease of bone often have raised levels of ALP, although some people with the condition have a normal ALP level and a high level can also be caused by some other conditions.

What kind of doctor do you see for Paget's disease of the breast?

As Paget's disease of the nipple is usually a sign of breast cancer, it's very important you see your GP if you notice changes to the tissue or skin of your breast. In particular, you should tell your GP if you notice any changes to: the skin of your nipple or areola (the darker area of skin around the nipple)

Does Pagets disease show up on a MRI?

Conclusions: Paget disease of the breast associated with underlying DCIS can be diagnosed at MRI of the breast and therefore impact management decisions.

How fast does Paget's disease of the breast progress?

The skin lesions progress slowly over months as scaly, fissured, or oozing erythema of the nipple and areola. Advanced lesions may appear as well-demarcated, eczema-like plaques with a pink or red hue. Although uncommon, the surface may appear slightly infiltrated and erosive, oozing, scaly or crusted [2].

What is the most common age for females to be diagnosed with Paget's disease?

Paget's disease is most common in people older than 50, and the risk of getting it increases with age. Most people who have it are able to lead normal lives.

Do you need chemo for Paget's disease?

After your operation, your doctor may recommend additional treatment (adjuvant therapy) with anti-cancer drugs (chemotherapy), radiation therapy or hormone therapy to prevent a recurrence of breast cancer.

Which bones are commonly affected by Paget's disease?

Paget's disease of bone can affect 1 bone or several bones. Commonly affected areas include the pelvis, spine and skull.

Is Paget's disease benign or malignant?

Paget's disease of the breast is a malignant (cancerous) condition that initially appears as chronic, inflammatory, “eczema-like” changes of the nipple and adjacent areas.

Which is the first line treatment for Paget's disease?

Bisphosphonates are first-line therapy for Paget's disease, and the advent of the new bisphosphonates permits a dramatic improvement in treatment.

What is the most common initial site of Paget's disease?

Paget's disease usually begins in the cancellous bone of an epiphysis or metaphysis. A diaphysis is the first site involved in some instances, and the anterior subperiosteal area of the proximal half of the tibia in a very small number of cases.

What does Paget's disease of the bone look like?

A doctor can usually diagnose Paget's disease by looking at an X-ray. An affected bone appears larger and more dense than usual. It can have a deformed shape. In the very early stages of Paget's disease, when there is just overactive absorption going on, it can look like there is a hole in the bone.