Is it OK to take clopidogrel every other day?

Since the therapeutic threshold required to prevent VLST in DES after 1 year is much lower, this degree of platelet inhibition

platelet inhibition

Antiplatelets can be classified based on the mechanism of action as follows[2][3]: Platelet aggregation inhibitors such as; Aspirin and related cyclooxygenase inhibitors. Oral thienopyridines such as clopidogrel, ticagrelor, ticlopidine, and prasugrel.

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Antiplatelet Medications - StatPearls - NCBI Bookshelf

can be conceivably achieved with just administering clopidogrel on alternate days.

Can clopidogrel be taken alternate days?

Beyond 30 days, these medications could be given on alternate days, one day aspirin and the other day clopidogrel.

How long can you go without clopidogrel?

Plavix is estimated to be cleared from your body in about 33 hours. A single, oral dose of Plavix (clopidogrel) 75 mg has a half-life of approximately 6 hours. It takes 5.5 x half-life of a medicine for a drug to leave the body, therefore most of the Plavix should be eliminated from your system in 5.5 x 6 = 33 hours.

What happens if I stop clopidogrel?

The patients were followed for nearly seven months, on average, after stopping Plavix. During that time, 17% of patients who had only gotten drug treatment and 8% of those who had gotten stents died or had a heart attack. Most of those cases happened in the first 90 days after stopping Plavix.

How long can you take clopidogrel?

Clopidogrel and low-dose aspirin

The key question for your doctor is whether the benefits outweigh the extra risk. This combination treatment is prescribed for a limited period of time, usually up to a maximum of 12 months.

Clopidogrel - How to take | Side Effects | Things to be aware

When is the best time to take clopidogrel 75 mg?

You can take clopidogrel at whatever time of day you find easiest to remember, but take your doses at the same time of day each day. Most people prefer to take it in the morning, as they find this helps them to remember to take it regularly. You can take the tablet either before or after a meal.

Which is safer aspirin or clopidogrel?

Aspirin combined with the antiplatelet drug clopidogrel is no better than aspirin alone for stroke prevention in people with a history of lacunar strokes, and the combination carries a greater risk of gastrointestinal bleeding, according to results of a trial funded by the National Institutes of Health.

How do I get off clopidogrel?

Do not stop taking clopidogrel without talking to your doctor. If you stop taking clopidogrel, your blood will start clotting at the same rate as before you started taking it, usually within 5 days of stopping the medicine. This means you may be at increased risk of serious problems like heart attacks or strokes.

What are the side effects of clopidogrel 75 mg?

Does clopidogrel affect blood pressure?

You likely won't have blood pressure changes while you're taking Plavix. However, sudden drops in blood pressure may be a symptom of serious internal bleeding, which is a possible side effect of Plavix.

What can you take instead of clopidogrel?

Besides oral anticoagulants, such as warfarin and the more recent dabigatran[9], and niche agents, such as cilostazol and ticlopidine[10,11], the most promising alternatives to clopidogrel in those with background aspirin therapy are prasugrel and ticagrelor.

Does clopidogrel affect the kidneys?

Conclusions. In summary, among patients hospitalized with ACS and treated with clopidogrel, lower levels of kidney function were associated with a greater risk of death, hospitalization for AMI, and major bleeding.

Can I drink coffee with clopidogrel?

These medications are used to slow blood clotting and include aspirin, clopidogrel (Plavix), ibuprofen (Advil, Motrin, and others), naproxen (Anaprox, Naprosyn, and others), enoxaparin (Lovenox), and more. Health experts advise caution when combining them with coffee, which can also slow blood clotting.

Can clopidogrel be halved?

The annual cost for one of the medications is more than $1,800. Finding the lowest effective dose for those patients could conceivably cut their bill in half. Major findings of the study show that: Half of patients taking clopidogrel were getting too little of the drug to prevent clotting most effectively.

How long should you take clopidogrel after a TIA?

Recent minor non-cardioembolic ischemic stroke or high-risk TIA, DAPT with aspirin plus clopidogrel should be initiated early (ideally within 12–24 hours of symptom onset and at least within 7 days of onset) and continued for 21–90 days.

How do you know if clopidogrel is working?

Talk to a pharmacist or your doctor before buying any over-the-counter medicine to check if it is compatible with clopidogrel. You may notice that you bruise or bleed more easily and it will take longer to stop bleeding while you are taking clopidogrel. This shows that clopidogrel is working.

Does clopidogrel affect sleep?

The organic nitrates (isosorbide) and the antiplatelet agents (acetylsalicylic acid, clopidogrel) are among the most prescribed drugs in cardiology and are not cited as causing insomnia or sleepiness.

What foods should I avoid when taking clopidogrel?

What should I monitor with clopidogrel?

HPR while on this drug is associated with major adverse cardiovascular events. The best assays to monitor clopidogrel therapy include VerifyNow and Multiplate ADP test.

Can clopidogrel cause anxiety?

headache, fever, weakness, feeling tired; little or no urination; a seizure; low blood sugar--headache, hunger, sweating, irritability, dizziness, fast heart rate, and feeling anxious or shaky; or.

Does clopidogrel cause joint pain?

Arthralgia and backache are also known to occur with its use. There have been case reports linking arthritis with the use of clopidogrel. We describe the case of a 64-year-old man who reported symptoms of fever and joint pains following initiation of therapy with clopidogrel.

Is clopidogrel 75 mg a blood thinner?

Clopidogrel is an antiplatelet blood-thinning medicine that may help prevent future heart attacks, strokes, and other clot-related diseases in patients who have already had a heart attack, stroke, or have certain cardiovascular conditions.

Can I stop Plavix suddenly?

You should never stop taking any prescribed medication without talking to your doctor, but especially not Plavix. Patients who stop taking Plavix can develop clotting and could suffer a heart attack or stroke or other damage to their cardiovascular system.

How long should I be on Plavix after stent?

It has been common practice for patients who have had a stent placed to clear a blocked artery to take an anti-clotting drug (such as Plavix, Effient, or Brilinta) plus aspirin for 12 months after the procedure. Taking these two medications, called dual anti-platelet therapy, reduces the risk of forming blood clots.

Does clopidogrel affect blood sugar?

These results could indicate that clopidogrel has glucose lowering effect and the FSG level in placebo treated group significantly elevated after the same course of treatment.