How successful is xiaflex?

Studies have shown 34% improvement in penile curvature in men who underwent treatment with Xiaflex injection compared to 18% improvement in men treated with saline injection.

What is the success rate of XIAFLEX for Peyronie's disease?

Success rates vary but studies demonstrate an average 34% improvement in the curvature (or 17-degree decrease from baseline curvature). 60% of men getting Xiaflex experienced improvement compared to 30% with placebo.

How long does it take XIAFLEX to work?

Treatment cycles are typically spaced about 4-6 weeks apart. Some men may see improvements after one or two cycles, while men with severe curvatures may benefit more from three or four cycles.

Does XIAFLEX dissolve plaque?

The main difference between Xiaflex and other injectable therapy is Xiaflex's ability to dissolve the collagenous fibrous tissue within the plaque (4,5).

How painful is XIAFLEX injection?

Horrible experience. Had three surgeries which eventually regressed, surgeon recommended trying xiaflex. Injections were extremely painful, he managed to partially straighten two fingers but ruptured my skin during a medieval straightening procedure. Regression was almost immediate despite splinting and exercising.

Melting Away Peyronies Disease? What You Need to Know About Xiaflex Treatment

Can XIAFLEX make peyronies worse?

Xiaflex can cause serous damage to the structure of the penis. After treatment, one of the tubes inside the penis could break during an erection, called penile fracture. This typically requires surgery. Damage to the penis may not get better after penile fracture, even with surgery.

Does XIAFLEX decrease size?

Xiaflex treatment for Peyronie's disease may improve penile curvature degree with no effect on the loss on penile length in post-marketing analysis. Paper presented at 2021 Sexual Medicine Society of North America Annual Meeting; October 21-24, 2021.

Why was XIAFLEX discontinued?

The decision to withdraw is not based on safety or efficacy concerns. Despite best efforts to appropriately educate the government and the market on XIAFLEX® over the past several years, the product did not receive government reimbursement approval and demand for the product has remained unsustainably low.

How do you break up Peyronie's plaque?

Intralesional collagenase injections (Xiaflex) are currently the only FDA-approved treatment for Peyronie's disease. Collagenase is an enzyme that helps break down the substances that make up plaques. Breaking down the plaques reduces penile curving and improves erectile function.

What to expect after XIAFLEX injections?

Pain, swelling, bruising, bleeding, redness, itching at or around the injection site may occur. Swollen, painful areas in the elbow and underarm (swollen lymph nodes) may also occur when this medication is injected in the hand. If any of these effects persist or worsen, tell your doctor promptly.

What is the latest treatment for Peyronie's disease?

Xiaflex (collagenase clostridium histolyticum) is an FDA approved prescription medicine that is administered by a trained professional only. Xiaflex is injected directly into the hardened tissue in two courses, and the area is massaged to successfully break down the scar tissue.

How often is XIAFLEX given?

Xiaflex is usually given in a treatment cycle of 1 to 3 injections given 4 weeks apart. After your injection, do not touch or put pressure on the treated area of the hand for the rest of the day. Keep the treated hand elevated until bedtime.

How successful is treatment for Peyronie's disease?

Treatments. In about 15 percent of cases, Peyronie's disease spontaneously resolves itself without treatment. However, more than 40 percent of cases may worsen. If treatment is necessary, oral medications, injections and surgery may be used.

How long does it take to recover from XIAFLEX?

“It took me several weeks to recover from the incisions followed by thirty physical therapy sessions after each surgery. With Xiaflex, the recuperative process took only two weeks, and I was back to normal.”

How much does an injection of XIAFLEX cost?

Doctors who administer the drug will have to be specially trained and certified. Pain, swelling and bruising can develop in the injection area. Xiaflex costs $3,300 an injection, so a full course of eight injections would cost about $26,000, in addition to a doctor's fee.

Is there an alternative to xiapex?

Unfortunately, Xiapex has been withdrawn from clinical use for Dupuytren's disease for commercial reasons. This is very disappointing as it was proving to highly effective. Mike is able to offer alternatives including percutaneous needles fasciotomy (PNF) or open surgery.

Why is XIAFLEX no longer available in Canada?

Notice : The Xiaflex was recently withdraw from the Canadian market by the US pharmaceutical company Endo for financial reasons. This drug is therefore no longer distributed in Canada. It is possible to obtain it through special permission from Health Canada.

Why was xiapex withdrawn?

The withdrawal was at the request of the marketing authorisation holder, Swedish Orphan Biovitrum AB (publ), which notified the European Commission of its decision to permanently discontinue the marketing of the product for commercial reasons.

Does XIAFLEX increase size?

Xiaflex with first generation PTT devices also had not impact on length. When patients used RestoreX along with the injection treatment, they experienced a nearly 2cm gain in length or about 17%.

Is XIAFLEX discontinued?

PRODUCT DISCONTINUATION FROM 28 JUNE 2019

It has provided a non-surgical option for patients with Dupuytren's Contracture and Peyronie's Disease.

Does Peyronie's plaque go away?

Peyronie's disease rarely goes away on its own. In most men with Peyronie's disease, the condition will remain as is or worsen. Early treatment soon after developing the condition may keep it from getting worse or even improve symptoms.

Is there a pill to cure Peyronie's disease?

The U.S. Food and Drug Administration today approved a new use for Xiaflex (collagenase clostridium histolyticum) as the first FDA-approved medicine to treat men with bothersome curvature of the penis, a condition known as Peyronie's disease.

How much does it cost to fix Peyronie's disease?

The mean annual, per-individual cost of Peyronie's disease treatment increased from $1,531 in 2007 to $10,339 in 2018. The cost increase was greatest for injectable therapies, which rose from $811 per individual in 2007 to $16,184 in 2018, a 19-fold increase.

How effective are injections for Peyronie's?

Results: Pain resolved in 97% of the patients who presented with pain after a mean of 2.5 injections. After therapy, 76% reported a subjective decrease in curvature, 9.5% noted an increase and 14.5% remained unchanged. Of the treated patients 72% reported an improvement in the ability to engage in coitus.