How much do statins lower PSA?

"On average, PSA declined by 4.1% after starting a statin," study researcher Robert J. Hamilton, MD, MPH, tells WebMD. "But what was really interesting was that the decline in PSA was proportional to the decline in cholesterol associated with the statin."

Do statins raise or lower PSA levels?

After adjusting for significant covariates (age, BMI, and race), statin use was shown to have a significant association with lower mean PSA (P = . 008) and lower mean testosterone (P < . 001) and similar total cholesterol (P = .

Does atorvastatin lower PSA?

The results of this study showed that: 1) Short term treatment with Atorvastatin can reduce serum PSA level, and 2) This reduction is more likely to be due to direct effect and is not related to lowering serum cholesterol levels.

How long does it take to lower PSA levels naturally?

Ejaculation Is a Potential Cause of Mildly Elevated PSA

PSA should return to normal in two to three days." To avoid this type of elevation, doctors will usually draw blood for a person's PSA level before doing a rectal exam.

Do statins reduce prostate cancer?

A 2006 Harvard study of 34,989 men linked statin use with a 49% lower risk of prostate cancer and a 61% lower risk of metastatic or fatal disease. The greatest protection was observed in the men who had been taking a statin drug the longest.

What to Avoid When Taking Statin Medications | How to Reduce Risk of Statin Side Effects

Does Lipitor affect PSA?

In a study recently published in the Journal of Clinical Oncology, a Stanford team led by urologist Joseph Presti, MD, describes its finding that certain widely prescribed medications - including statin drugs such as Lipitor (atorvastatin) and Zocor (simvastatin), and nonsteroidal antiinflammatory drugs (NSAIDs) such ...

Do statins help enlarged prostate?

Conclusion: Statins have no significant effect on the incidence of BPH, but statins can reduce the risk of BPH for patients over 60 years old. For patients with hyperlipidemia, the duration of medication is more than 1 year, which can slow down the progression of LUTS.

What is the average PSA for a 70 year old?

3.5-4.5: Normal for a man 60-70 yrs. 4.5-5.5: Normal for a man 70-80 yrs.

How can I lower my PSA quickly?

What is the best supplement to lower PSA?

CHICAGO, Illinois — A commercially available food supplement that contains pomegranate, broccoli, green tea, and turmeric significantly lowers prostate-specific antigen (PSA) levels, compared with placebo, in patients with prostate cancer, a double-blind placebo-controlled randomized trial has shown.

Does high cholesterol affect PSA levels?

“We found the higher the cholesterol level, the higher the PSA level in otherwise healthy men,” said investigator Stephen Freedland, MD, associate professor of urology and pathology in the Duke Prostate Center at Duke University School of Medicine in Durham, N.C.

Can statins increase PSA?

Key Findings

Among statin users, no significant increase in incidence was observed between the screening and control groups (6.9 vs 5.9/1,000 person-years, RR = 1.02, 95% CI = 0.95–1.10; P < .

What medications increase PSA levels?

Does ibuprofen lower PSA?

Regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin and ibuprofen may decrease serum levels of PSA, which could affect detection of prostate cancer, according to a report in Cancer (2008; published online ahead of print).

Can high cholesterol affect your prostate?

Men in the highest vs lowest tertile of total cholesterol had a 42% increased risk of Gleason 8–10 prostate cancer, Finnish study finds. High cholesterol levels are associated with an increased short-term risk of prostate cancer (PCa), particularly aggressive PCa, according to a new study.

Can vitamin D lower PSA?

A double-blinded clinical study found that vitamin D supplementation reduced prostate specific antigen (PSA) level and enhanced survival rate in patients with prostate cancer [14].

At what PSA level should a biopsy be done?

A lower percent-free PSA means that your chance of having prostate cancer is higher and you should probably have a biopsy. Many doctors recommend a prostate biopsy for men whose percent-free PSA is 10% or less, and advise that men consider a biopsy if it is between 10% and 25%.

What is the highest PSA level ever recorded?

In this study, the highest PSA detected was 23,162 ng/mL.

How painful is a biopsy of the prostate?

You will feel some pressure when the probe is inserted, but it is usually not painful. Usually between 6 – 12 (sometimes more) prostatic tissue samples are obtained and the entire procedure lasts about 10 minutes. A local anesthetic can be used to numb the area and reduce any pain.

What is a normal PSA for a 74 year old?

The median serum PSA level (5th to 95th percentile) for the entire cohort was 1.9 ng/mL (0.3–8.9 ng/mL). The median PSA levels (5th to 95th percentile) rose from 1.6 ng/mL (0.4–7.5 ng/mL) in men aged 70–74 years up to 2.8 ng/mL (0.1–18.0 ng/mL) in men aged 90 years and over (Box 2).

What PSA indicates metastasis?

Conclusions: Serum PSA < 20 ng/ml have high predictive value in ruling out skeletal metastasis.

What are the side effects of atorvastatin?

What medications can decrease PSA levels?

Use of nonsteroidal anti-inflammatory drugs (NSAIDS), statins, or thiazide diuretics significantly lowers prostate-specific antigen (PSA) levels in men without a history of prostate cancer, new data indicate.

How much do PSA levels fluctuate?

Kevin Loughlin, M.D., M.B.A., director of Urologic Research at Brigham and Women's Hospital, responds: Variations in PSA like yours aren't particularly remarkable. In fact, fluctuations in PSA of up to 36% from one day to the next may have nothing to do with cancer.

Does zinc lower PSA levels?

A cutoff value of 100 microg/mL for serum zinc concentration provided a sensitivity of 90.5% and a specificity of 32.7% in elevated PSA range, and a sensitivity of 93.3% and specificity of 27.1% in gray zone, respectively.