How long does it take for CIN 2 to progress to CIN 3?

In a meta-analysis of 36 studies (both randomized trials and observational studies) including 3160 patients with CIN 2, at 24 months, lesions regressed in 50 percent of patients, persisted in 32 percent, and progressed to CIN 3+ in 18 percent [14].

How fast does CIN 2 progress to CIN3?

In a meta-analysis of 36 studies involving 3,160 women with CIN2 who were actively monitored for at least 3 months, 50% of the lesions regressed spontaneously, 32% persisted, and just under one in five (18%) progressed to CIN3 or worse within 2 years.

How quickly can CIN3 develop?

It has been estimated that the mean calculated time from infection to diagnosis of CIN3+ is 9.4 years (SD 4.1 years) and progression from CIN3 to invasive cervical cancer takes 10–20 years, depending on genotype [7, 8].

Can CIN 2 turn into CIN3?

CIN 1 lesions generally clear up on their own. CIN 2 lesions often clear up on their own, but can also progress to CIN 3 lesions. CIN 3 is the most severe. It's a very slow-growing disease, though: fewer than half of CIN 3 lesions will have become cancer within 30 years.

Does CIN 2 always need treatment?

Right now, CIN2 is typically treated. But some studies have suggested that CIN2 lesions often regress completely without treatment and should therefore be simply monitored instead.

What is CIN

Should I worry about CIN 2?

CIN 2. CIN 2 means two-thirds of the thickness of the cervical surface layer is affected by abnormal cells. There is a higher risk the abnormal cells will develop into cervical cancer.

Can CIN 2 regress?

Conclusion: CIN2 lesions regress without treatment in one year, although an ablative procedure is more effective. However, excision of CIN2 may lead to additional morbidity and costs, and tailoring the management on an individual basis may result in better outcome. Misclassification of CIN2 is not a negligible problem.

How long before HPV causes cell changes?

The time from getting HPV to developing warts, cervical cell changes or cervical cancer varies. Although most people clear HPV within 2 years, we know that HPV can stay in the body for a long time before causing any problems. Cervical screening (a smear test) can help detect the virus and any cell changes early.

Is CGIN worse than CIN?

CGIN is usually classified as low grade (mild) or high grade (severe). High grade CGIN is the equivalent of CIN3. CGIN can be multi-focal – this means that more than one area is affected at one time, with normal tissue lying between them.

How long does it take to go from CIN1 to CIN3?

There are three grades of CIN (CIN1,2&3) and even CIN3 starts 10 years before cervical cancer. CIN2 & CIN3 are high grade changes and need to be treated to prevent future risk of cervical cancer whereas CIN1 (low grade changes) will often resolve spontaneously.

What type of HPV causes CIN 3?

The main predictor of subsequent risk of CIN3 or worse was HPV16 persistence. One positive test and persistence for high-risk HPV types other than HPV16, HPV18, HPV31, and HPV33 were associated with low absolute risks of CIN3 or worse that lasted for years.

What are the chances of CIN 3 returning?

[6]. Authors [7], in particular, reported that the rate of persistence of HPV infection after conization for CIN 3 was approximately 20, and 46% of these patients with persistent HPV infection developed CIN relapse at 4–10 months after treatment.

Is CIN 2 precancerous?

CIN – The outer surface of the cervix is composed of cells called squamous cells. A precancerous lesion affecting these cells is called CIN. These changes are categorized as being mild (CIN 1) or moderate to severe (CIN 2 or 3).

What happens if CIN 2 is left untreated?

High-Grade Abnormalities CIN-2 & CIN-3

These cells are more likely to become cancerous and invade deeper layers of the cervix if left untreated. If high-grade abnormalities are detected on a Pap smear, the woman is advised to have a colposcopy and biopsy.

What type of HPV causes CIN 2?

Results: HPV was detected in 92.9% of women with CIN 2-3 and high-risk HPV (HR-HPV) was detected in 85.8% of them. In women with cervical cancer, HPV was positive in 96.5%, HR-HPV detected in 93%.

Is CIN 3 precancerous cells?

CIN 3 is not cancer, but may become cancer and spread to nearby normal tissue if not treated. Treatment for CIN 3 may include cryotherapy, laser therapy, loop electrosurgical procedure (LEEP), or cone biopsy to remove or destroy the abnormal tissue. CIN 3 is sometimes called high-grade or severe dysplasia.

What is the difference between CIN 2 and CIN3?

CIN2 – indicates moderate changes; affecting two-thirds of the thickness of the surface layer of the cervix. CIN3 – indicates more severe changes (not cancer); affecting the full thickness of the surface layer of the cervix.

What is cin1 CIN 2 CIN3?

CIN 1: Refers to abnormal cells affecting about one-third of the thickness of the epithelium. CIN 2: Refers to abnormal cells affecting about one-third to two-thirds of the epithelium. CIN 3: Refers to abnormal cells affecting more than two-thirds of the epithelium.

Can precancerous cells come back after LEEP?

LEEP works very well to treat abnormal cell changes on the cervix. If all of the abnormal tissue is removed, you won't need more surgery. In some studies, doctors were able to remove all the abnormal cells in almost every case. But abnormal cells may come back in the future.

How long after HPV can you have an abnormal Pap?

Q: How long after exposure does it usually take for something to be detectable? A: Changes consistent with HPV can usually be detected within 3-6 months after exposure to the infection.

Can HPV cause abnormal cells in a year?

When a high-risk HPV infection of cervical cells lasts many years, the cells can become abnormal. These changes can get worse over time and may become cervical cancer.

Does HPV go away after LEEP?

Although LEEP does not completely eradicate HPV infection, our results indicate that most HR-HPV infections are cleared after LEEP with negative margins. The clearance rate is increasing gradually after surgery. Our persistence rate was 40.9 % at 6 months, 20 % at 12 months and 11.8 % at 18 months.

How long does a LEEP take?

Your provider may prescribe LEEP if a Pap test and colposcopy find abnormal cell growths. The procedure takes about 20 minutes, and the full recovery time is about four weeks.

What happens after loop excision?

After LEEP, you may rest for a few minutes after the procedure before going home. You may want to wear a sanitary pad for bleeding. It is normal to have some mild cramping, spotting, and dark or black-colored discharge for several days. The dark discharge is from the medicine applied to your cervix to control bleeding.

When do you need a cone biopsy?

Cone biopsy is done to detect cervical cancer or early changes that lead to cancer. A cone biopsy is done if a test called colposcopy cannot find the cause of an abnormal Pap smear. Cone biopsy may also be used to treat: Moderate to severe types of abnormal cell changes (called CIN II or CIN III)