How is xiaflex administered?

The dose of XIAFLEX® is 0.58 mg per injection into a palpable cord with a contracture of a metacarpophalangeal (MP) joint or a proximal interphalangeal (PIP) joint. Each vial of XIAFLEX® and sterile diluent should only be used for a single injection.

How is XIAFLEX injected?

Xiaflex is injected directly into the "cord" of the affected hand or into a "plaque" of the penis. A healthcare provider will give you this injection. Follow your doctor's dosing instructions very carefully.

Do XIAFLEX injections hurt?

Pain. Although Xiaflex is not uncomfortable to receive, some patients have significant pain for up to 48 hours after the injection, with rare patients having discomfort beyond this period.

How long does it take for XIAFLEX to work for Peyronie's disease?

Some men may see improvements after one or two cycles, while men with severe curvatures may benefit more from three or four cycles.

How many XIAFLEX injections do I need?

No more than 3 injections, each 4 weeks apart, should be given in the same area. If you are using this medication to treat Peyronie's disease, the medication is injected into the plaque in the penis by your healthcare provider.

Optimizing Outcomes with Xiaflex Injections

Where do you inject XIAFLEX?

The dose of XIAFLEX® is 0.58 mg per injection into a palpable cord with a contracture of a metacarpophalangeal (MP) joint or a proximal interphalangeal (PIP) joint.

Why was XIAFLEX discontinued?

The decision to withdraw is not based on safety or efficacy concerns. Despite best efforts to appropriately educate the government and the market on XIAFLEX® over the past several years, the product did not receive government reimbursement approval and demand for the product has remained unsustainably low.

Can XIAFLEX make peyronies worse?

Xiaflex can cause serous damage to the structure of the penis. After treatment, one of the tubes inside the penis could break during an erection, called penile fracture. This typically requires surgery. Damage to the penis may not get better after penile fracture, even with surgery.

What is the success rate of XIAFLEX for Peyronie's disease?

Success rates vary but studies demonstrate an average 34% improvement in the curvature (or 17-degree decrease from baseline curvature). 60% of men getting Xiaflex experienced improvement compared to 30% with placebo.

Does XIAFLEX really work for Peyronie's disease?

Xiaflex is administered in 4 cycles and 2 injections per cycle approximately 3-5 days apart. Patients will have between 8-10 clinic visits. Two large randomized controlled trials (IMPRESS 1 & 2) showed 33% improvement in curvature in the medication group.

Can you drive after XIAFLEX injection?

You will be able to drive yourself home after the appointment. You may use ice as needed for 15-20 minutes to reduce swelling. You may take Tylenol or Ibuprofen as needed for pain.

What to expect after XIAFLEX injections?

The most common side effects with XIAFLEX for the treatment of Dupuytren's contracture include: swelling of the injection site or the hand. bruising or bleeding at the injection site. pain or tenderness of the injection site or the hand.

Does XIAFLEX decrease size?

Xiaflex treatment for Peyronie's disease may improve penile curvature degree with no effect on the loss on penile length in post-marketing analysis. Paper presented at 2021 Sexual Medicine Society of North America Annual Meeting; October 21-24, 2021.

How many times can you have XIAFLEX?

Xiaflex is given in treatment cycles for Peyronie's disease. For each treatment cycle, you'll receive two injections 1 to 3 days apart. You may have up to four treatment cycles at 6-week intervals.

How long does it take to recover from XIAFLEX?

“It took me several weeks to recover from the incisions followed by thirty physical therapy sessions after each surgery. With Xiaflex, the recuperative process took only two weeks, and I was back to normal.”

How much do XIAFLEX injections cost?

Doctors who administer the drug will have to be specially trained and certified. Pain, swelling and bruising can develop in the injection area. Xiaflex costs $3,300 an injection, so a full course of eight injections would cost about $26,000, in addition to a doctor's fee.

What is the newest treatment for Peyronie's disease?

Xiaflex (collagenase clostridium histolyticum) is an FDA approved prescription medicine that is administered by a trained professional only. Xiaflex is injected directly into the hardened tissue in two courses, and the area is massaged to successfully break down the scar tissue.

How much does it cost to fix Peyronie's disease?

The mean annual, per-individual cost of Peyronie's disease treatment increased from $1,531 in 2007 to $10,339 in 2018. The cost increase was greatest for injectable therapies, which rose from $811 per individual in 2007 to $16,184 in 2018, a 19-fold increase.

How effective are injections for Peyronie's?

Results: Pain resolved in 97% of the patients who presented with pain after a mean of 2.5 injections. After therapy, 76% reported a subjective decrease in curvature, 9.5% noted an increase and 14.5% remained unchanged. Of the treated patients 72% reported an improvement in the ability to engage in coitus.

Is there an alternative to xiapex?

Unfortunately, Xiapex has been withdrawn from clinical use for Dupuytren's disease for commercial reasons. This is very disappointing as it was proving to highly effective. Mike is able to offer alternatives including percutaneous needles fasciotomy (PNF) or open surgery.

Why was xiapex withdrawn?

The withdrawal was at the request of the marketing authorisation holder, Swedish Orphan Biovitrum AB (publ), which notified the European Commission of its decision to permanently discontinue the marketing of the product for commercial reasons.

Why is XIAFLEX no longer available in Canada?

Notice : The Xiaflex was recently withdraw from the Canadian market by the US pharmaceutical company Endo for financial reasons. This drug is therefore no longer distributed in Canada. It is possible to obtain it through special permission from Health Canada.

Who can administer XIAFLEX?

It can be administered right in a doctor's office on contractures ranging from less severe to more severe. Physicians listed on this website are not affiliated with Endo Pharmaceuticals Inc. and do not pay to be on this list or to be designated as experienced users of XIAFLEX^®.

Does XIAFLEX increase length?

Regarding length improvements, not surprisingly, CCH (Xiaflex) alone did not result in any improvement in lost length. Xiaflex with first generation PTT devices also had not impact on length. When patients used RestoreX along with the injection treatment, they experienced a nearly 2cm gain in length or about 17%.