How is ferritin an inflammatory marker?

We argue here that serum ferritin arises from damaged cells, and is thus a marker of cellular damage. The protein in serum ferritin is considered benign, but it has lost (i.e. dumped) most of its normal complement of iron which when unliganded is highly toxic.

Is iron an inflammatory marker?

Inflammatory chronic diseases are also profoundly influenced by iron status. Increased iron stores are correlated with markers of chronic inflammation and other well-established risk factors of diabetes, obesity, and metabolic syndrome (26, 40, 43, 60, 119, 152).

What inflammatory conditions cause high ferritin levels?

Abstract. Objective: A markedly elevated serum ferritin level has been associated with inflammatory conditions such as adult-onset Still's disease, systemic juvenile idiopathic arthritis, and hemophagocytic lymphohistiocytosis/macrophage activation syndrome.

What is ferritin a marker of?

Ferritin is a blood protein that contains iron. A ferritin test helps your doctor understand how much iron your body stores. If a ferritin test reveals that your blood ferritin level is lower than normal, it indicates your body's iron stores are low and you have iron deficiency.

Is ferritin a biomarker?

Serum ferritin generally represents a biomarker of choice when iron deficiency is suspected. However, ferritin is also an acute-phase-protein exhibiting elevated serum concentration in various inflammatory diseases.

Serum Ferritin test || It's role in inflammation

Why is ferritin high with inflammation?

Ferritin molecules help sequester this free iron, preventing its participation in this reaction and subsequent free radical-mediated cellular damage. Beyond this protective role in redox biology and iron homeostasis, free serum ferritin is increased in the setting of ongoing inflammation.

Does high ferritin mean inflammation?

It is well known that serum ferritin is an acute-phase reactant, reflecting the degree of acute and chronic inflammation in several systemic diseases. However, emerging evidence suggests a potential causative role for ferritin in the inflammatory process [4].

Does low ferritin cause inflammation?

]. Our study showed a positive correlation between ferritin and CRP, signifying an underlying low grade inflammation, leading to subsequent iron deficiency, most probably, because of inflammation mediated iron sequestration in the reticuloendothelial system.

What are the inflammatory markers?

The three most commonly used inflammatory markers are called C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and plasma viscosity (PV).

Does high ferritin cause joint pain?

Symptoms. Symptoms of hereditary hemochromatosis often appear in midlife. Early symptoms may be nonspecific and often include joint pain, fatigue and weakness.

Can arthritis cause high ferritin levels?

Inflammatory arthritis is the most likely primary cause of the elevated ferritin level.

How does inflammation affect iron levels?

In anemia of inflammation, you may have a normal or sometimes increased amount of iron link stored in your body tissues, but a low level of iron in your blood. Inflammation may prevent your body from using stored iron to make enough healthy red blood cells, leading to anemia.

What cancers show high ferritin levels?

Ferritin is often elevated in the serum of cancer patients including those with neuroblastoma (63), Hodgkinson's lymphoma (64), cervical (65), oral squamous cell (66), renal cell (67), T cell lymphoma (68), CRC (69), and breast (70) cancers and were often associated with increased tumor grade and shorter survival.

What is the significance of ferritin in Covid?

Vargas-Vargas et al. [Extract-No abstract available] Ferritin is a key mediator of immune dysregulation, especially under extreme hyperferritinemia, via direct immune-suppressive and pro-inflammatory effects, contributing to the cytokine storm.

Whats the difference between ferritin and iron?

What is the difference between iron and ferritin? Iron is an important mineral present in red blood cells that carries oxygen to cells in the body. Ferritin on the other hand is a protein that stores iron and releases iron when the body needs it.

Can low ferritin cause joint pain?

Furthermore, headache and muscle and joint pain associated with iron deficiency are repeatedly considered migraine and fibromyalgia syndrome, respectively 3, 19. The multitude of symptoms is commonly associated low ferritin concentration without anemia 1, 17, 20, 21, 22.

What raised inflammatory markers?

Overall, 15 per cent of raised inflammatory markers were caused by disease: 6.3 per cent were the result of infections, 5.6 per cent were caused by autoimmune conditions, and 3.7 per cent were due to cancers.

What blood tests show chronic inflammation?

How does low ferritin affect the body?

Ferritin is a protein that stores iron. Red blood cells need iron to form normally and carry oxygen around your body. Other parts of your body, such as your liver, bone marrow, and muscles, also need iron. Low levels of ferritin lead to iron-deficiency anemia.

How does anemia cause inflammation?

In anemia of inflammation, the body does not recycle iron as easily, so it is "held up" in cells such as macrophages (a type of white blood cell). There is also decreased iron absorption from the intestines. These changes are caused by a protein called hepcidin.

What causes elevated ferritin levels?

Higher than normal ferritin levels can mean you have too much iron in your body. Conditions that cause increased iron levels include liver disease, alcohol abuse, and hemochromatosis, a disorder that can lead to cirrhosis, heart disease, and diabetes.

What are symptoms of high ferritin levels?

Can fatty liver cause high ferritin levels?

Abstract. Serum ferritin (SF) levels are commonly elevated in patients with nonalcoholic fatty liver disease (NAFLD) because of systemic inflammation, increased iron stores, or both.

Can stress cause high ferritin levels?

In contrast, chronic inflammation and oxidative stress may act as a link between elevated serum-ferritin levels, which may contribute to cellular or tissue damage [10].

Can high ferritin be reversed?

There's currently no cure for haemochromatosis, but there are treatments that can reduce the amount of iron in your body. This can help relieve some of the symptoms and reduce the risk of damage to organs such as the heart, liver and pancreas.