How does the COVID-19 vaccine interact to create immunity?

After vaccination, the mRNA will enter the muscle cells. Once inside, they use the cells' machinery to produce a harmless piece of what is called the spike protein. The spike protein is found on the surface of the virus that causes COVID-19. After the protein piece is made, our cells break down the mRNA and remove it.
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How does the COVID-19 vaccine boost your immune system?

Vaccines work by stimulating your immune system to produce antibodies, exactly like it would if you were exposed to the disease. After getting vaccinated, you develop immunity to that disease, without having to get the disease first.
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How does the COVID-19 vaccine work?

COVID-19 vaccines help our bodies develop immunity to the virus that causes COVID-19 without us having to get the illness.
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How does the mRNA COVID-19 vaccines work?

(Individuals who get an mRNA vaccine are not exposed to the virus, nor can they become infected by the vaccine.) Using this mRNA blueprint, cells produce the viral protein. As part of a normal immune response, the immune system recognizes that the protein is foreign and produces specialized proteins called antibodies.
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Does the COVID-19 vaccine reduce the risk of getting "Long COVID"?

Reseach is showing that people who are vaccinated, even with just one dose, tend to have lower rates of long COVID-19 after catching the virus than those who are unvaccinated.
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COVID-19 Symposium: Immune Responses After mRNA Vaccination | Dr. Michela Locci



How many times can I get COVID-19?

'A long-term pattern' According to some infectious disease researchers, Covid-19 reinfections are likely to become more common as time goes on and different variants continue to circulate—with some people potentially seeing third or fourth reinfections within a year.
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Should you get the COVID-19 vaccine if you already had COVID-19 and recovered?


If I already had COVID-19 and recovered, do I still need to get a COVID-19 vaccine? You should get a COVID-19 vaccine even if you already had COVID-19. Getting a COVID-19 vaccine after you recover from COVID-19 infection provides added protection to your immune system.

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Are mRNA COVID-19 vaccines safe?


mRNA vaccines are safe and effective.
mRNA vaccines have been held to the same rigorous safety and effectiveness standards as all other types of vaccines in the United States.

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Is there a live virus in the mRNA COVID-19 vaccines?

The mRNA vaccines do not contain any live virus. Instead, they work by teaching our cells to make a harmless piece of a “spike protein,” which is found on the surface of the virus that causes COVID-19. After making the protein piece, cells display it on their surface.
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How does the Johnson and Johnson COVID-19 vaccine work?


The J&J/Janssen COVID-19 vaccine also contains a piece of a modified virus that is not the virus that causes COVID-19. This modified virus is called the vector virus. The vector virus cannot reproduce itself, so it is harmless. This vector virus gives instructions to cells in the body to create an immune response.

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How long do COVID-19 vaccines last?

It is normal for virus-fighting antibodies—such as those that are stimulated by a COVID-19 vaccine—to wane over time. Monitoring antibody levels in the blood is one way to measure vaccine efficacy and research has found that protection remains high for six months after the second shot of a Pfizer or Moderna vaccine.

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Is it normal to feel sick after having the COVID-19 vaccine?

It is normal to feel sick after getting a COVID-19 vaccine.
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How does the Pfizer-BioNTech COVID-19 vaccine work?

The Pfizer-BioNTech COVID-19 vaccine (COMIRNATY) also contains a harmless piece of messenger RNA (mRNA). The COVID-19 mRNA teaches cells in the body how to create an immune response to the virus that causes COVID-19. This response helps protect you from getting sick with COVID-19 in the future.

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Why don't you get sick after the COVID-19 vaccine?


But you don't actually get sick because your body is only exposed to a small portion of the virus and not the intact virus that can cause the disease. The antibodies against the spike protein remain in your body and are available and ready to protect you if you're exposed to the SARS-CoV-2 virus.

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Does your immune system get stronger after COVID-19?


Any time you catch a virus and recover from the illness, you retain antibodies. These antibodies help your body fight off future infections so that you either don't get sick or have milder symptoms.

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How long does it take for immunity to wane after receiving the COVID-19 vaccine?


A study published by the U.S. Centers for Disease Control and Prevention found that immunity against severe COVID-19 begins to wane four months after receiving a so-called "booster" third dose of the Pfizer or Moderna vaccines.

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Does the COVID-19 vaccine have a live virus?


None of the vaccines authorized for use in the U.S. contain a live virus. mRNA and viral vector vaccines are the two types of currently authorized COVID-19 vaccines available.

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What are the severe allergic reactions to COVID-19 mRNA vaccines?


“Overall, severe allergic reactions to COVID-19 mRNA vaccines, including life-threatening anaphylaxis reactions such as low blood pressure and difficulty breathing, are rare, on the order of five cases per million vaccine doses administered,” noted Dr. Guerrerio.

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Can you get the COVID-19 vaccine if you have an allergic reaction?


If you have had an immediate allergic reaction (a reaction that started within 4 hours) to any vaccine other than a COVID-19 vaccine or any injectable therapy, you may still be able to get a COVID-19 vaccine. However, your doctor may refer you to an allergy and immunology specialist for additional care or advice.

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Are there any safety concerns concerning mRNA technology of the Pfizer-BioNTech COVID-19 Vaccine?

FDA does not have specific safety concerns with a vaccine that utilizes this technology.

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Do mRNA COVID-19 vaccines cause heart inflammation?


These cases typically occur in male adolescents and young adults after the second dose, and within a week of vaccination. It is important to seek medical care if symptomatic (chest pain, shortness of breath, having a fast beating, fluttering, or pounding heart).

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Is the COVID-19 vaccine safe?


COVID-19 vaccines are safe and effective. You may have side effects after vaccination, but these are normal.

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Can you get COVID-19 if you already had it and have antibodies?


It is important to remember that some people with antibodies to SARS-CoV-2 may become infected after vaccination (vaccine breakthrough infection) or after recovering from a past infection (reinfected).

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Can you still test positive after recovering from COVID-19?

According to the Centers for Disease Control and Prevention, some people who contract COVID-19 can have detectable virus for up to three months, but that doesn't mean they are contagious. When it comes to testing, however, the PCR tests are more likely to continue picking up the virus following infection.
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How long could the COVID-19 virus linger in your body?

But for most infected people, virus levels in the body peak between three and six days after the original infection, and the immune system clears the pathogen within 10 days. The virus shed after this period is generally not infectious.
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