How does Chagas disease affect the body?

Chronic phase

Heart failure. Sudden cardiac arrest. Difficulty swallowing due to enlarged esophagus. Stomach pain or constipation due to enlarged colon.

What body systems does Chagas disease affect?

The symptomatic chronic stage affects the nervous system, digestive system and heart. These symptoms are due to killing of affected tissue, and corresponding inflammation and scarring. If left untreated, Chagas disease can be fatal, in most cases due to heart muscle damage.

How does Chagas disease affect the nervous system?

In the chronic phase, it presents as neuritis that results in altered tendon reflexes and sensory impairment, and is reported in up to 10% of the patients. Isolated cases of central nervous system involvement can also include dementia, confusion, chronic encephalopathy and sensitive and motor deficits.

How fatal is Chagas disease?

Chagas disease (T. cruzi infection) is also referred to as American trypanosomiasis. It is estimated that as many as 8 million people in Mexico, Central America, and South America have Chagas disease, most of whom do not know they are infected. If untreated, infection is lifelong and can be life threatening.

Does Chagas disease go away?

If untreated, infection is lifelong. Acute Chagas disease occurs immediately after infection, and can last up to a few weeks or months. During the acute phase, parasites may be found in the circulating blood. This phase of infection is usually mild or asymptomatic.

KILLER DISEASES | How Chagas Disease Affects the Body

Does Chagas affect the brain?

The involvement of the central nervous system (CNS) during human acute and chronic Chagas disease (CD) has been largely reported. Meningoencephalitis is a frequent finding during the acute infection, while during chronic phase the CNS involvement is often accompanied by behavioral and cognitive impairments.

Can you get tested for Chagas?

The diagnosis of Chagas disease can be made by observation of the parasite in a blood smear by microscopic examination. A thick and thin blood smear are made and stained for visualization of parasites.

How do I get rid of Chagas?

To kill the parasite, Chagas disease can be treated with benznidazole or nifurtimox. Both medicines are nearly 100% effective in curing the disease if given soon after infection at the onset of the acute phase, including the cases of congenital transmission.

Can you cure chronic Chagas?

Once Chagas disease reaches the chronic phase, medications won't cure the disease. But, the drugs may be offered to people younger than age 50 because they may help slow the progression of the disease and its most serious complications.

What states do kissing bugs live in?

Most of the world's kissing bugs are in Central and South America and Mexico. They've also been found in the United States in the lower 28 states, with higher concentrations in Texas, Arizona and New Mexico. Kissing bugs have been spotted a far north as Delaware, Ohio and Pennsylvania.

What is the major concern for chronic Chagas disease patients?

Nearly 30% of chronically-infected patients become symptomatic, often with a latency of 10-30 years, developing life-threatening complications. Of those, nearly 90% develop Chagas heart disease, while the others manifest gastrointestinal disease and neuronal disorders.

Who is most likely to get Chagas disease?

Chagas disease is a disease caused by the parasite Trypanosoma cruzi. You're most at risk for Chagas disease if you have visited or traveled in rural Central or South America or been exposed to the blood products, or received organs, from someone infected with Chagas disease.

Why is Chagas a silent disease?

Chagas disease is prevalent among poor populations of continental Latin America but is increasingly being detected in other countries and continents. It is often termed as a “silent and silenced disease” as the infected majority have no symptoms or extremely mild symptom.

What is the symptom onset of Chagas disease?

Symptoms of Chagas disease in the acute phase (the first few weeks or months) are: Mild, flu-like symptoms, such as fever, fatigue, body aches, and headaches. Rash. Loss of appetite.

Is Chagas disease permanent?

Chagas disease is curable if treated soon after infection. Unfortunately, most infected people are unaware of their infection until it's too late, and they present with complications of chronic heart or bowel problems.

What is the drug of choice for Chagas disease?

* Benznidazole is FDA-approved for the treatment of Chagas disease (American trypanosomiasis) caused by Trypanosoma cruzi in pediatric patients 2–12 years of age.

Can ivermectin cure Chagas disease?

Ivermectin and Chagas disease

To our knowledge, a connection between ivermectin and T. cruzi has never been described in the literature (in neither animal reservoirs nor humans). 1 17 To the best of our knowledge, there is currently no evidence that would justify CD treatment with ivermectin.

Should I be worried about Chagas disease?

Decades after being infected, about 30 percent of those who have Chagas develop serious health effects, including cardiomyopathy (disease of the heart muscle), heart failure, heart rhythm problems, and strokes. Less common are disorders that affect the digestive system.

How common is Chagas disease in USA?

More than 5 million people worldwide have Chagas disease. In the United States, there are estimated to be at least 300,000 cases of chronic Chagas disease among people originally from countries of Latin America where Chagas disease is endemic.

Do blood banks test for Chagas?

Yes. In the United States, donors are tested once and if the result of their test is negative for T. cruzi infection, they will not be tested when they donate again at that blood bank.

How much is a Chagas test?

Results: The cost of Chagas' disease test in the blood bank of Seccional Bolívar was COP$ 37,804 (USD$ 12), and the blood bag and immunohematology test costs were COP$ 25,941 (USD$ 8.2) and COP$ 6,800 (USD$ 2.2), respectively.

Is Chagas disease autoimmune?

In fact, the first evidence of autoimmunity in CD was presented by Cossio and collaborators in 1974 (61), who reported antibodies in sera of chagasic patients that reacted with endocardium, interstitium, and heart blood vessels but were absent in healthy individuals and in patients with non-chagasic cardiomyopathy.

Why do we still have not a vaccine against Chagas disease?

Undoubtedly, most vaccination attempts yielded attenuated infections. However, attenuation does not equate with a cure, and we still do not have a sound diagnostic method for “cure” in Chagas disease, not only for asymptomatic human cases and for vaccinated animals but also for the testing of drugs.

Which country has the most Chagas disease?

Chagas disease is the most prevalent communicable tropical disease in Latin America. The most important vectors are the Triatoma infestans in Argentina, Bolivia, Brazil, Chile, Paraguay, Uruguay and Peru; the R. prolixus in Colombia, Venezuela and Central America; the T.