How deep does Voltaren penetrate?

An aqueous solution of diclofenac has been shown to penetrate to a depth of around 3–4 mm into the underlying dermis and subcutaneous tissue⁵⁶. Skin permeability and local tissue concentrations of non-steroidal anti-inflammatory drugs after topical application.

How much Voltaren is absorbed through the skin?

Absorption amounts to about 6% of the dose of diclofenac after topical application of 2.5 g Voltaren Emulgel per 500 cm2 skin, determined by reference to the total renal elimination compared with Voltaren tablets. Occlusion over a period of 10 hours leads to a three-fold increase in the amount of diclofenac absorbed.

Does topical Voltaren get into your bloodstream?

Roach: Since topical applications of creams like Voltaren or Aspercream are absorbed into the bloodstream and circulate throughout the body, and do not go directly to the site of pain, is there an advantage to using them over oral NSAIDs?

Does Voltaren gel penetrate the skin?

Conclusions: After topical application, diclofenac can penetrate the skin and permeate to deeper tissues, where it reaches a concentration that appears to be sufficient to exert a therapeutic effect.

How long does it take Voltaren to absorb into your skin?

For Voltaren® 1% topical gel: After applying this medicine, do not shower, bathe, or wash the affected area for at least 1 hour. Wait for at least 10 minutes before covering the treated skin with gloves or clothing.

Voltaren Penetrates Deep to Treat Arthritis Pain at the Source

Why can't you put Voltaren on your back?

It reduces inflammation and pain. Voltaren gel is approved for use on arm and leg joints only. It has not been studied for use in the hips or spine. You should not use Voltaren gel to treat muscle pain in other areas of the body, such as the lower back.

Should Voltaren be rubbed in?

Gently rub the medication into the entire affected joint, usually 4 times daily or as directed by your doctor. You may use the dosing card to apply the medication. Do not apply the medication on skin that has cuts, infections, or rashes.

Why can't you put Voltaren gel on your shoulder?

For superficial joints – like hands, wrists and even knees – it can be very effective. However, the joints of the cervical spine in the neck, and most of the shoulder joint, are deeper than the Voltaren can penetrate. Voltaren is not appreciably absorbed into the blood, so all of its actions are local.

What happens if you use too much Voltaren gel?

Taking too much diclofenac sodium does not usually cause serious problems. The person may have some stomach pain and vomiting (possibly with blood). However, these symptoms will likely get better. In rare cases, a blood transfusion is needed.

How is Voltaren absorbed?

Diclofenac sodium, the active substance of Voltaren®, is totally absorbed following both oral and rectal administration and is excreted, mainly in metabolised form, partly in the urine and partly in the bile. The extent of its biliary excretion varies from species to species.

How much topical diclofenac is absorbed?

The diclofenac absorption in the 1% concentration applied on the healthy skin reached 6 to 7% in healthy individuals. The diclofenac concentration was measured on plasma and tissue and synovial fluid after topical administration in the hands and knees joints.

How is topical diclofenac absorbed?

Topical diclofenac is absorbed through the skin and penetrates into subdermal tissues, including synovial tissue, to act directly at the site of pain and inflammation [17].

How long does it take diclofenac gel to absorb?

The doses of diclofenac are the same for each. If you're using diclofenac gel, plasters or patches on your skin, it usually takes 1 to 2 days to work. For arthritis, you may need to use the gel for up to 7 days on the painful joint to feel the full effect.

Do you rub in diclofenac gel?

Apply diclofenac gel on clean, dry skin. Apply the gel to two joints only. For example, a hand and an elbow, a knee and an ankle or two knees. Use your hands to gently rub the gel into your skin.

Can you use Voltaren Gel indefinitely?

Therefore, Voltaren can be used as an anti-inflammatory and analgesic agent not only in short-term therapy but also in the long-term treatment of chronic diseases.

Does Voltaren Gel raise blood pressure?

NSAIDs, including Voltaren Gel, can lead to high blood pressure or worsening of high blood pressure, which may add to the increased risk of heart attack and stroke. There is a potential for elevation in liver function tests during treatment with diclofenac containing products.

How long does it take Voltaren Gel to start working?

How long does Voltaren gel take to relieve pain? It doesn't take long for Voltaren to get to work. For neck pain relief, for instance, a study shows that Voltaren reduces the pain felt upon movement, after just one hour of application; and that it cuts pain in half within 24 hours.

Why can't you use Voltaren on your hip?

Why can't I use Voltaren Arthritis Pain Gel for shoulders, hips, etc.? Voltaren has not been studied for the relief of arthritis pain in the shoulders, hips, and back.

Is biofreeze the same as Voltaren?

Biofreeze contains menthol, and like other menthol-containing products, it alleviates pain via counter-irritation, specifically cooling the surface of the skin. Voltaren instead treats pain by temporarily blocking the production of pain-signaling chemicals called prostaglandins.

Why do you have to stop using Voltaren after 21 days?

Consumers should stop use and seek medical attention if their arthritis pain is not improved in 7 days or they need to use the product for more than 21 days. The active ingredient in Voltaren Arthritis Pain, diclofenac, may cause a severe allergic reaction, especially in people allergic to aspirin.

Where should you not apply Voltaren?

Apply the medicine very carefully to clean, dry skin, and avoid getting any in your eyes, nose, or mouth. Do not apply this medicine to areas with broken skin or open wounds, infection, or severely peeling skin. Apply enough medicine each time to cover the entire affected area.

Can you apply too much Voltaren?

Voltaren Arthritis Pain gel can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Even people without heart disease or risk factors could have a stroke or heart attack while using Voltaren Arthritis Pain gel.

Does Voltaren reduce inflammation or just pain?

Like other NSAIDs, Voltaren (diclofenac) works by reducing inflammation in the body. When taken in oral form, it's used to treat pain related to such forms of arthritis as osteoarthrtis, rheumatoid arthritis, and ankylosing spondylitis. The oral version of this drug is still available only by prescription.

Why is Voltaren not long term?

Long-term treatment with Voltaren can change your liver enzymes. On a blood test, your levels might be higher than normal even before you have symptoms. This can be a sign of serious liver problems that could lead to the need for a liver transplant or even be fatal if not treated.